Effects of polysaccharides from wild morels on immune response and gut microbiota composition in non-treated and cyclophosphamide-treated mice
Polysaccharides isolated from mushrooms have been identified as potential prebiotics that could impact gut microbiota. In this study, a water-soluble polysaccharide (MP) extracted from wild morels was evaluated for its effects on the gut microbiota of non-treated and cyclophosphamide (CP)-treated mi...
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| Veröffentlicht in: | Food & function 2020-05, Vol.11 (5), p.4291-433 |
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| creator | Huo, Wenyan Feng, Zhengping Hu, Suying Cui, Langjun Qiao, Ting Dai, Lu Qi, Peng Zhang, Liguang Liu, Yu Li, Junzhi |
| description | Polysaccharides isolated from mushrooms have been identified as potential prebiotics that could impact gut microbiota. In this study, a water-soluble polysaccharide (MP) extracted from wild morels was evaluated for its effects on the gut microbiota of non-treated and cyclophosphamide (CP)-treated mice. The results showed that MP restored the spleen weight and increased the counts of white blood cells and lymphocytes in the peripheral blood and spleen of the CP-treated mice. Mice treated with MP exhibited increased levels of short-chain fatty acid (SCFA)-producing bacteria, especially
Lachnospiraceae
, compared to normal mice, and increased levels of
Bacteroidetes
and SCFA-producing bacteria, especially
Ruminococcaceae
, compared to the CP-treated mice. Moreover, MP treatment increased the production of valeric acid and decreased the production of acetic acid in the non-treated mice and increased the production of acetic acid, propionic acid, butyric acid, and valeric acid in the CP-treated mice. These results show that MP is potentially good for health.
Polysaccharides from wild morels alter gut microbiota, increase the production of SCFAs and promote the proliferation of lymphocytes in mice. |
| doi_str_mv | 10.1039/d0fo00597e |
| format | Article |
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Lachnospiraceae
, compared to normal mice, and increased levels of
Bacteroidetes
and SCFA-producing bacteria, especially
Ruminococcaceae
, compared to the CP-treated mice. Moreover, MP treatment increased the production of valeric acid and decreased the production of acetic acid in the non-treated mice and increased the production of acetic acid, propionic acid, butyric acid, and valeric acid in the CP-treated mice. These results show that MP is potentially good for health.
Polysaccharides from wild morels alter gut microbiota, increase the production of SCFAs and promote the proliferation of lymphocytes in mice.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d0fo00597e</identifier><identifier>PMID: 32356856</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Acetic acid ; Agaricales ; Animals ; Bacteria ; Butyric acid ; Cyclophosphamide ; Fatty acids ; Gastrointestinal Microbiome - drug effects ; Immune response ; Immunity - drug effects ; Intestinal microflora ; Leukocytes ; Lymphocytes ; Male ; Mice ; Mice, Inbred Strains ; Microbiota ; Mushrooms ; Peripheral blood ; Phytotherapy ; Plant Extracts - pharmacology ; Polysaccharides ; Polysaccharides - pharmacology ; Prebiotics ; Propionic acid ; Rodents ; Saccharides ; Spleen ; Valeric acid</subject><ispartof>Food & function, 2020-05, Vol.11 (5), p.4291-433</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-c5d25c5bf9afdfa20792903fc2ee2977967c8a829eab47786d683ff9c8e5a7ca3</citedby><cites>FETCH-LOGICAL-c429t-c5d25c5bf9afdfa20792903fc2ee2977967c8a829eab47786d683ff9c8e5a7ca3</cites><orcidid>0000-0001-5623-6010</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32356856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huo, Wenyan</creatorcontrib><creatorcontrib>Feng, Zhengping</creatorcontrib><creatorcontrib>Hu, Suying</creatorcontrib><creatorcontrib>Cui, Langjun</creatorcontrib><creatorcontrib>Qiao, Ting</creatorcontrib><creatorcontrib>Dai, Lu</creatorcontrib><creatorcontrib>Qi, Peng</creatorcontrib><creatorcontrib>Zhang, Liguang</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Li, Junzhi</creatorcontrib><title>Effects of polysaccharides from wild morels on immune response and gut microbiota composition in non-treated and cyclophosphamide-treated mice</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Polysaccharides isolated from mushrooms have been identified as potential prebiotics that could impact gut microbiota. In this study, a water-soluble polysaccharide (MP) extracted from wild morels was evaluated for its effects on the gut microbiota of non-treated and cyclophosphamide (CP)-treated mice. The results showed that MP restored the spleen weight and increased the counts of white blood cells and lymphocytes in the peripheral blood and spleen of the CP-treated mice. Mice treated with MP exhibited increased levels of short-chain fatty acid (SCFA)-producing bacteria, especially
Lachnospiraceae
, compared to normal mice, and increased levels of
Bacteroidetes
and SCFA-producing bacteria, especially
Ruminococcaceae
, compared to the CP-treated mice. Moreover, MP treatment increased the production of valeric acid and decreased the production of acetic acid in the non-treated mice and increased the production of acetic acid, propionic acid, butyric acid, and valeric acid in the CP-treated mice. These results show that MP is potentially good for health.
Polysaccharides from wild morels alter gut microbiota, increase the production of SCFAs and promote the proliferation of lymphocytes in mice.</description><subject>Acetic acid</subject><subject>Agaricales</subject><subject>Animals</subject><subject>Bacteria</subject><subject>Butyric acid</subject><subject>Cyclophosphamide</subject><subject>Fatty acids</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Immune response</subject><subject>Immunity - drug effects</subject><subject>Intestinal microflora</subject><subject>Leukocytes</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Microbiota</subject><subject>Mushrooms</subject><subject>Peripheral blood</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Polysaccharides</subject><subject>Polysaccharides - pharmacology</subject><subject>Prebiotics</subject><subject>Propionic acid</subject><subject>Rodents</subject><subject>Saccharides</subject><subject>Spleen</subject><subject>Valeric acid</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9LAzEQxYMotqgX70rEm7CaJpvs5ii1_gHBi4K3JU0mdstmsya7SL-En9loa705lxl4P94wbxA6npDLCWHyyhDrCeGygB00piSnmeDkdfd3zqUYoaMYlyQVk7KU5T4aMcq4KLkYo8-ZtaD7iL3FnW9WUWm9UKE2ELEN3uGPujHY-QBNYlpcOze0gAPEzrcRsGoNfht67God_Lz2vcLau87Huq-_8Ra3vs36AKoH80PrlW58t_CxWyiX9mzFZAGHaM-qJsLRph-gl9vZ8_Q-e3y6e5heP2Y6p7LPNDeUaz63UlljFSWFpJIwqykAlUUhRaFLVVIJap4XRSmMKJm1UpfAVaEVO0Dna98u-PcBYl8t_RDatLKiOREiF5yxRF2sqXRbjAFs1YXaqbCqJqT6Tr-6IbdPP-nPEny6sRzmDswW_c06ASdrIES9Vf_el_Sz__SqM5Z9AXr0mIM</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Huo, Wenyan</creator><creator>Feng, Zhengping</creator><creator>Hu, Suying</creator><creator>Cui, Langjun</creator><creator>Qiao, Ting</creator><creator>Dai, Lu</creator><creator>Qi, Peng</creator><creator>Zhang, Liguang</creator><creator>Liu, Yu</creator><creator>Li, Junzhi</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-5623-6010</orcidid></search><sort><creationdate>20200501</creationdate><title>Effects of polysaccharides from wild morels on immune response and gut microbiota composition in non-treated and cyclophosphamide-treated mice</title><author>Huo, Wenyan ; Feng, Zhengping ; Hu, Suying ; Cui, Langjun ; Qiao, Ting ; Dai, Lu ; Qi, Peng ; Zhang, Liguang ; Liu, Yu ; Li, Junzhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-c5d25c5bf9afdfa20792903fc2ee2977967c8a829eab47786d683ff9c8e5a7ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetic acid</topic><topic>Agaricales</topic><topic>Animals</topic><topic>Bacteria</topic><topic>Butyric acid</topic><topic>Cyclophosphamide</topic><topic>Fatty acids</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Immune response</topic><topic>Immunity - drug effects</topic><topic>Intestinal microflora</topic><topic>Leukocytes</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Microbiota</topic><topic>Mushrooms</topic><topic>Peripheral blood</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Polysaccharides</topic><topic>Polysaccharides - pharmacology</topic><topic>Prebiotics</topic><topic>Propionic acid</topic><topic>Rodents</topic><topic>Saccharides</topic><topic>Spleen</topic><topic>Valeric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huo, Wenyan</creatorcontrib><creatorcontrib>Feng, Zhengping</creatorcontrib><creatorcontrib>Hu, Suying</creatorcontrib><creatorcontrib>Cui, Langjun</creatorcontrib><creatorcontrib>Qiao, Ting</creatorcontrib><creatorcontrib>Dai, Lu</creatorcontrib><creatorcontrib>Qi, Peng</creatorcontrib><creatorcontrib>Zhang, Liguang</creatorcontrib><creatorcontrib>Liu, Yu</creatorcontrib><creatorcontrib>Li, Junzhi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huo, Wenyan</au><au>Feng, Zhengping</au><au>Hu, Suying</au><au>Cui, Langjun</au><au>Qiao, Ting</au><au>Dai, Lu</au><au>Qi, Peng</au><au>Zhang, Liguang</au><au>Liu, Yu</au><au>Li, Junzhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of polysaccharides from wild morels on immune response and gut microbiota composition in non-treated and cyclophosphamide-treated mice</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>11</volume><issue>5</issue><spage>4291</spage><epage>433</epage><pages>4291-433</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Polysaccharides isolated from mushrooms have been identified as potential prebiotics that could impact gut microbiota. In this study, a water-soluble polysaccharide (MP) extracted from wild morels was evaluated for its effects on the gut microbiota of non-treated and cyclophosphamide (CP)-treated mice. The results showed that MP restored the spleen weight and increased the counts of white blood cells and lymphocytes in the peripheral blood and spleen of the CP-treated mice. Mice treated with MP exhibited increased levels of short-chain fatty acid (SCFA)-producing bacteria, especially
Lachnospiraceae
, compared to normal mice, and increased levels of
Bacteroidetes
and SCFA-producing bacteria, especially
Ruminococcaceae
, compared to the CP-treated mice. Moreover, MP treatment increased the production of valeric acid and decreased the production of acetic acid in the non-treated mice and increased the production of acetic acid, propionic acid, butyric acid, and valeric acid in the CP-treated mice. These results show that MP is potentially good for health.
Polysaccharides from wild morels alter gut microbiota, increase the production of SCFAs and promote the proliferation of lymphocytes in mice.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32356856</pmid><doi>10.1039/d0fo00597e</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-5623-6010</orcidid></addata></record> |
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| subjects | Acetic acid Agaricales Animals Bacteria Butyric acid Cyclophosphamide Fatty acids Gastrointestinal Microbiome - drug effects Immune response Immunity - drug effects Intestinal microflora Leukocytes Lymphocytes Male Mice Mice, Inbred Strains Microbiota Mushrooms Peripheral blood Phytotherapy Plant Extracts - pharmacology Polysaccharides Polysaccharides - pharmacology Prebiotics Propionic acid Rodents Saccharides Spleen Valeric acid |
| title | Effects of polysaccharides from wild morels on immune response and gut microbiota composition in non-treated and cyclophosphamide-treated mice |
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