CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers
Abstract Context and Objectives The Controlled Antenatal Thyroid Screening Study I (CATS-I) was a randomized controlled trial investigating the effects of levothyroxine therapy for suboptimal gestational thyroid function (SGTF), comparing outcomes in children of treated (SGTF-T) with untreated (SGTF...
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| creator | Muller, Ilaria Taylor, Peter N Daniel, Rhian M Hales, Charlotte Scholz, Anna Candler, Toby Pettit, Rebecca J Evans, William D Shillabeer, Dionne Draman, Mohd S Dayan, Colin M Tang, Hiu K C Okosieme, Onyebuchi Gregory, John W Lazarus, John H Rees, D Aled Ludgate, Marian E |
| description | Abstract
Context and Objectives
The Controlled Antenatal Thyroid Screening Study I (CATS-I) was a randomized controlled trial investigating the effects of levothyroxine therapy for suboptimal gestational thyroid function (SGTF), comparing outcomes in children of treated (SGTF-T) with untreated (SGTF-U) women during pregnancy. This follow-up study, CATS-II, reports the long-term effects on anthropometric, bone, and cardiometabolic outcomes in mothers and offspring and includes a group with normal gestational thyroid function (NGTF).
Design & Participants
332 mothers (197 NGTF, 56 SGTF-U, 79 SGTF-T) aged 41.2±5.3 years (mean±SD) and 326 paired children assessed 9.3±1.0 years after birth for (i) body mass index (BMI); (ii) lean, fat, and bone mass by dual-energy X-ray absorptiometry; (iii) blood pressure, augmentation index, and aortic pulse-wave-velocity; and (iv) thyroid function, lipids, insulin, and adiponectin. The difference between group means was compared using linear regression.
Results
Offspring’s measurements were similar between groups. Although maternal BMI was similar between groups at CATS-I, after 9 years (at CATS-II) SGTF-U mothers showed higher BMI (median [interquartile ratio] 28.3 [24.6-32.6] kg/m2) compared with NGTF (25.8 [22.9-30.0] kg/m2; P = 0.029), driven by fat mass increase. At CATS-II SGTF-U mothers also had higher thyroid-stimulating hormone (TSH) values (2.45 [1.43-3.50] mU/L) than NGTF (1.54 [1.12-2.07] mU/L; P = 0.015), since 64% had never received levothyroxine. At CATS-II, SGTF-T mothers had BMI (25.8 [23.1-29.8] kg/m2, P = 0.672) and TSH (1.68 [0.89-2.96] mU/L; P = 0.474) values similar to NGTF mothers.
Conclusions
Levothyroxine supplementation of women with SGTF did not affect long-term offspring anthropometric, bone, and cardiometabolic measurements. However, absence of treatment was associated with sustained long-term increase in BMI and fat mass in women with SGTF. |
| doi_str_mv | 10.1210/clinem/dgaa129 |
| format | Article |
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Context and Objectives
The Controlled Antenatal Thyroid Screening Study I (CATS-I) was a randomized controlled trial investigating the effects of levothyroxine therapy for suboptimal gestational thyroid function (SGTF), comparing outcomes in children of treated (SGTF-T) with untreated (SGTF-U) women during pregnancy. This follow-up study, CATS-II, reports the long-term effects on anthropometric, bone, and cardiometabolic outcomes in mothers and offspring and includes a group with normal gestational thyroid function (NGTF).
Design & Participants
332 mothers (197 NGTF, 56 SGTF-U, 79 SGTF-T) aged 41.2±5.3 years (mean±SD) and 326 paired children assessed 9.3±1.0 years after birth for (i) body mass index (BMI); (ii) lean, fat, and bone mass by dual-energy X-ray absorptiometry; (iii) blood pressure, augmentation index, and aortic pulse-wave-velocity; and (iv) thyroid function, lipids, insulin, and adiponectin. The difference between group means was compared using linear regression.
Results
Offspring’s measurements were similar between groups. Although maternal BMI was similar between groups at CATS-I, after 9 years (at CATS-II) SGTF-U mothers showed higher BMI (median [interquartile ratio] 28.3 [24.6-32.6] kg/m2) compared with NGTF (25.8 [22.9-30.0] kg/m2; P = 0.029), driven by fat mass increase. At CATS-II SGTF-U mothers also had higher thyroid-stimulating hormone (TSH) values (2.45 [1.43-3.50] mU/L) than NGTF (1.54 [1.12-2.07] mU/L; P = 0.015), since 64% had never received levothyroxine. At CATS-II, SGTF-T mothers had BMI (25.8 [23.1-29.8] kg/m2, P = 0.672) and TSH (1.68 [0.89-2.96] mU/L; P = 0.474) values similar to NGTF mothers.
Conclusions
Levothyroxine supplementation of women with SGTF did not affect long-term offspring anthropometric, bone, and cardiometabolic measurements. However, absence of treatment was associated with sustained long-term increase in BMI and fat mass in women with SGTF.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/clinem/dgaa129</identifier><identifier>PMID: 32396189</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Absorptiometry, Photon ; Adiponectin ; Adiponectin - blood ; Anthropometry ; Aorta ; Blood pressure ; Blood Pressure - physiology ; Body Composition - physiology ; Body fat ; Body Mass Index ; Body measurements ; Bone Density - physiology ; Bone mass ; Care and treatment ; Child ; Children ; Diagnosis ; Dual energy X-ray absorptiometry ; Female ; Health aspects ; Humans ; Hypothyroidism - drug therapy ; Hypothyroidism - physiopathology ; Insulin ; Insulin - blood ; Lipids ; Lipids - blood ; Long bone ; Long-term effects ; Male ; Maternal-fetal exchange ; Metabolic diseases ; Offspring ; Pregnancy ; Pregnancy Complications - drug therapy ; Pregnancy Complications - physiopathology ; Prenatal Exposure Delayed Effects - blood ; Prenatal Exposure Delayed Effects - physiopathology ; Risk factors ; Supplements ; Thyroid ; Thyroid diseases ; Thyroid gland ; Thyroid Gland - physiopathology ; Thyroid-stimulating hormone ; Thyroxine ; Thyroxine - therapeutic use</subject><ispartof>The journal of clinical endocrinology and metabolism, 2020-07, Vol.105 (7), p.2150-2161</ispartof><rights>Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020</rights><rights>Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><rights>Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-4980894e6f0ff12eb02b20fbadf75fdbb26e1706d4a76be34e7fce0ed8c42b5f3</citedby><cites>FETCH-LOGICAL-c464t-4980894e6f0ff12eb02b20fbadf75fdbb26e1706d4a76be34e7fce0ed8c42b5f3</cites><orcidid>0000-0003-2926-0722</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2405343897?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21368,27903,27904,33723,43784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32396189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muller, Ilaria</creatorcontrib><creatorcontrib>Taylor, Peter N</creatorcontrib><creatorcontrib>Daniel, Rhian M</creatorcontrib><creatorcontrib>Hales, Charlotte</creatorcontrib><creatorcontrib>Scholz, Anna</creatorcontrib><creatorcontrib>Candler, Toby</creatorcontrib><creatorcontrib>Pettit, Rebecca J</creatorcontrib><creatorcontrib>Evans, William D</creatorcontrib><creatorcontrib>Shillabeer, Dionne</creatorcontrib><creatorcontrib>Draman, Mohd S</creatorcontrib><creatorcontrib>Dayan, Colin M</creatorcontrib><creatorcontrib>Tang, Hiu K C</creatorcontrib><creatorcontrib>Okosieme, Onyebuchi</creatorcontrib><creatorcontrib>Gregory, John W</creatorcontrib><creatorcontrib>Lazarus, John H</creatorcontrib><creatorcontrib>Rees, D Aled</creatorcontrib><creatorcontrib>Ludgate, Marian E</creatorcontrib><title>CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Context and Objectives
The Controlled Antenatal Thyroid Screening Study I (CATS-I) was a randomized controlled trial investigating the effects of levothyroxine therapy for suboptimal gestational thyroid function (SGTF), comparing outcomes in children of treated (SGTF-T) with untreated (SGTF-U) women during pregnancy. This follow-up study, CATS-II, reports the long-term effects on anthropometric, bone, and cardiometabolic outcomes in mothers and offspring and includes a group with normal gestational thyroid function (NGTF).
Design & Participants
332 mothers (197 NGTF, 56 SGTF-U, 79 SGTF-T) aged 41.2±5.3 years (mean±SD) and 326 paired children assessed 9.3±1.0 years after birth for (i) body mass index (BMI); (ii) lean, fat, and bone mass by dual-energy X-ray absorptiometry; (iii) blood pressure, augmentation index, and aortic pulse-wave-velocity; and (iv) thyroid function, lipids, insulin, and adiponectin. The difference between group means was compared using linear regression.
Results
Offspring’s measurements were similar between groups. Although maternal BMI was similar between groups at CATS-I, after 9 years (at CATS-II) SGTF-U mothers showed higher BMI (median [interquartile ratio] 28.3 [24.6-32.6] kg/m2) compared with NGTF (25.8 [22.9-30.0] kg/m2; P = 0.029), driven by fat mass increase. At CATS-II SGTF-U mothers also had higher thyroid-stimulating hormone (TSH) values (2.45 [1.43-3.50] mU/L) than NGTF (1.54 [1.12-2.07] mU/L; P = 0.015), since 64% had never received levothyroxine. At CATS-II, SGTF-T mothers had BMI (25.8 [23.1-29.8] kg/m2, P = 0.672) and TSH (1.68 [0.89-2.96] mU/L; P = 0.474) values similar to NGTF mothers.
Conclusions
Levothyroxine supplementation of women with SGTF did not affect long-term offspring anthropometric, bone, and cardiometabolic measurements. However, absence of treatment was associated with sustained long-term increase in BMI and fat mass in women with SGTF.</description><subject>Absorptiometry, Photon</subject><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Anthropometry</subject><subject>Aorta</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Body Composition - physiology</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Body measurements</subject><subject>Bone Density - physiology</subject><subject>Bone mass</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Children</subject><subject>Diagnosis</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypothyroidism - drug therapy</subject><subject>Hypothyroidism - physiopathology</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Long bone</subject><subject>Long-term effects</subject><subject>Male</subject><subject>Maternal-fetal exchange</subject><subject>Metabolic diseases</subject><subject>Offspring</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - drug therapy</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Prenatal Exposure Delayed Effects - blood</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Risk factors</subject><subject>Supplements</subject><subject>Thyroid</subject><subject>Thyroid diseases</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - physiopathology</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroxine</subject><subject>Thyroxine - therapeutic use</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1rGzEQhkVpady01x6LoKceNpG02g8djUlag0MOcaE3IWlHtsKutJW00Pz7KthtL4Eyh_ngmZdhXoQ-UnJFGSXXZnQepuvhoBRl4hVaUcGbqqOie41WhDBaiY79uEDvUnokhHLe1G_RRc1q0dJerNCvzXr_gLdbvAv-UGWIE177fIxhDhPk6AxWfsB3kJUOY-lurAWTEw4W36mCezXih0VXYc5uKvX--BSDG_Dt4k12wWPn8b21aY7OH05aIR8hpvfojVVjgg_nfIm-397sN9-q3f3X7Wa9qwxvea646EkvOLSWWEsZaMI0I1arwXaNHbRmLdCOtANXXauh5tBZAwSG3nCmG1tfos8n3TmGnwukLB_D8nx2koyTpuZ1L7p_1EGNIJ23IUdlJpeMXLecNbQRDS3U1QtUiQEmZ4IH68r8pQUTQ0oRrCx_mFR8kpTIZ__kyT959q8sfDpfu-gJhr_4H8MK8OUEhGX-n9hvh2emWg</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Muller, Ilaria</creator><creator>Taylor, Peter N</creator><creator>Daniel, Rhian M</creator><creator>Hales, Charlotte</creator><creator>Scholz, Anna</creator><creator>Candler, Toby</creator><creator>Pettit, Rebecca J</creator><creator>Evans, William D</creator><creator>Shillabeer, Dionne</creator><creator>Draman, Mohd S</creator><creator>Dayan, Colin M</creator><creator>Tang, Hiu K C</creator><creator>Okosieme, Onyebuchi</creator><creator>Gregory, John W</creator><creator>Lazarus, John H</creator><creator>Rees, D Aled</creator><creator>Ludgate, Marian E</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-2926-0722</orcidid></search><sort><creationdate>20200701</creationdate><title>CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers</title><author>Muller, Ilaria ; Taylor, Peter N ; Daniel, Rhian M ; Hales, Charlotte ; Scholz, Anna ; Candler, Toby ; Pettit, Rebecca J ; Evans, William D ; Shillabeer, Dionne ; Draman, Mohd S ; Dayan, Colin M ; Tang, Hiu K C ; Okosieme, Onyebuchi ; Gregory, John W ; Lazarus, John H ; Rees, D Aled ; Ludgate, Marian E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-4980894e6f0ff12eb02b20fbadf75fdbb26e1706d4a76be34e7fce0ed8c42b5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Absorptiometry, Photon</topic><topic>Adiponectin</topic><topic>Adiponectin - blood</topic><topic>Anthropometry</topic><topic>Aorta</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Body Composition - physiology</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Body measurements</topic><topic>Bone Density - physiology</topic><topic>Bone mass</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Children</topic><topic>Diagnosis</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypothyroidism - drug therapy</topic><topic>Hypothyroidism - physiopathology</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Long bone</topic><topic>Long-term effects</topic><topic>Male</topic><topic>Maternal-fetal exchange</topic><topic>Metabolic diseases</topic><topic>Offspring</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - drug therapy</topic><topic>Pregnancy Complications - physiopathology</topic><topic>Prenatal Exposure Delayed Effects - blood</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Risk factors</topic><topic>Supplements</topic><topic>Thyroid</topic><topic>Thyroid diseases</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - physiopathology</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroxine</topic><topic>Thyroxine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muller, Ilaria</creatorcontrib><creatorcontrib>Taylor, Peter N</creatorcontrib><creatorcontrib>Daniel, Rhian M</creatorcontrib><creatorcontrib>Hales, Charlotte</creatorcontrib><creatorcontrib>Scholz, Anna</creatorcontrib><creatorcontrib>Candler, Toby</creatorcontrib><creatorcontrib>Pettit, Rebecca J</creatorcontrib><creatorcontrib>Evans, William D</creatorcontrib><creatorcontrib>Shillabeer, Dionne</creatorcontrib><creatorcontrib>Draman, Mohd S</creatorcontrib><creatorcontrib>Dayan, Colin M</creatorcontrib><creatorcontrib>Tang, Hiu K C</creatorcontrib><creatorcontrib>Okosieme, Onyebuchi</creatorcontrib><creatorcontrib>Gregory, John W</creatorcontrib><creatorcontrib>Lazarus, John H</creatorcontrib><creatorcontrib>Rees, D Aled</creatorcontrib><creatorcontrib>Ludgate, Marian E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muller, Ilaria</au><au>Taylor, Peter N</au><au>Daniel, Rhian M</au><au>Hales, Charlotte</au><au>Scholz, Anna</au><au>Candler, Toby</au><au>Pettit, Rebecca J</au><au>Evans, William D</au><au>Shillabeer, Dionne</au><au>Draman, Mohd S</au><au>Dayan, Colin M</au><au>Tang, Hiu K C</au><au>Okosieme, Onyebuchi</au><au>Gregory, John W</au><au>Lazarus, John H</au><au>Rees, D Aled</au><au>Ludgate, Marian E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>105</volume><issue>7</issue><spage>2150</spage><epage>2161</epage><pages>2150-2161</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Context and Objectives
The Controlled Antenatal Thyroid Screening Study I (CATS-I) was a randomized controlled trial investigating the effects of levothyroxine therapy for suboptimal gestational thyroid function (SGTF), comparing outcomes in children of treated (SGTF-T) with untreated (SGTF-U) women during pregnancy. This follow-up study, CATS-II, reports the long-term effects on anthropometric, bone, and cardiometabolic outcomes in mothers and offspring and includes a group with normal gestational thyroid function (NGTF).
Design & Participants
332 mothers (197 NGTF, 56 SGTF-U, 79 SGTF-T) aged 41.2±5.3 years (mean±SD) and 326 paired children assessed 9.3±1.0 years after birth for (i) body mass index (BMI); (ii) lean, fat, and bone mass by dual-energy X-ray absorptiometry; (iii) blood pressure, augmentation index, and aortic pulse-wave-velocity; and (iv) thyroid function, lipids, insulin, and adiponectin. The difference between group means was compared using linear regression.
Results
Offspring’s measurements were similar between groups. Although maternal BMI was similar between groups at CATS-I, after 9 years (at CATS-II) SGTF-U mothers showed higher BMI (median [interquartile ratio] 28.3 [24.6-32.6] kg/m2) compared with NGTF (25.8 [22.9-30.0] kg/m2; P = 0.029), driven by fat mass increase. At CATS-II SGTF-U mothers also had higher thyroid-stimulating hormone (TSH) values (2.45 [1.43-3.50] mU/L) than NGTF (1.54 [1.12-2.07] mU/L; P = 0.015), since 64% had never received levothyroxine. At CATS-II, SGTF-T mothers had BMI (25.8 [23.1-29.8] kg/m2, P = 0.672) and TSH (1.68 [0.89-2.96] mU/L; P = 0.474) values similar to NGTF mothers.
Conclusions
Levothyroxine supplementation of women with SGTF did not affect long-term offspring anthropometric, bone, and cardiometabolic measurements. However, absence of treatment was associated with sustained long-term increase in BMI and fat mass in women with SGTF.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32396189</pmid><doi>10.1210/clinem/dgaa129</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-2926-0722</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2020-07, Vol.105 (7), p.2150-2161 |
| issn | 0021-972X 1945-7197 |
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| recordid | cdi_proquest_journals_2405343897 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; ProQuest Central |
| subjects | Absorptiometry, Photon Adiponectin Adiponectin - blood Anthropometry Aorta Blood pressure Blood Pressure - physiology Body Composition - physiology Body fat Body Mass Index Body measurements Bone Density - physiology Bone mass Care and treatment Child Children Diagnosis Dual energy X-ray absorptiometry Female Health aspects Humans Hypothyroidism - drug therapy Hypothyroidism - physiopathology Insulin Insulin - blood Lipids Lipids - blood Long bone Long-term effects Male Maternal-fetal exchange Metabolic diseases Offspring Pregnancy Pregnancy Complications - drug therapy Pregnancy Complications - physiopathology Prenatal Exposure Delayed Effects - blood Prenatal Exposure Delayed Effects - physiopathology Risk factors Supplements Thyroid Thyroid diseases Thyroid gland Thyroid Gland - physiopathology Thyroid-stimulating hormone Thyroxine Thyroxine - therapeutic use |
| title | CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T06%3A13%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CATS%20II%20Long-term%20Anthropometric%20and%20Metabolic%20Effects%20of%20Maternal%20Sub-optimal%20Thyroid%20Function%20in%20Offspring%20and%20Mothers&rft.jtitle=The%20journal%20of%20clinical%20endocrinology%20and%20metabolism&rft.au=Muller,%20Ilaria&rft.date=2020-07-01&rft.volume=105&rft.issue=7&rft.spage=2150&rft.epage=2161&rft.pages=2150-2161&rft.issn=0021-972X&rft.eissn=1945-7197&rft_id=info:doi/10.1210/clinem/dgaa129&rft_dat=%3Cgale_proqu%3EA642515951%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2405343897&rft_id=info:pmid/32396189&rft_galeid=A642515951&rft_oup_id=10.1210/clinem/dgaa129&rfr_iscdi=true |