2-(Dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines: synthesis and anticancer activity
Aim. Synthesis of a series of 2-(dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines and evaluation in vitro of their anticancer activity against a panel of 60 cell lines derived from nine cancer types, namely leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal...
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| container_title | Biopolimery i kletka |
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| creator | Velihina, Ye. S. Pil’o, S. G. Zyabrev, V. S. Moskvina, V. S. Shablykina, O. V. Brovarets, V. S. |
| description | Aim. Synthesis of a series of 2-(dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines and evaluation in vitro of their anticancer activity against a panel of 60 cell lines derived from nine cancer types, namely leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, breast cancer. Methods. Organic synthesis; biological tests; spectral methods; statistical methods. Results. In vitro screening of the anticancer activity showed that 5 of 26 tested compounds can effectively inhibit the growth of certain cancer cell lines. Conclusions. New type of N-(2,2-dichloro-1-cyanoethenyl)carboxamides heterocyclization with 1H-pyrazol-5-amines led to the formation of 2-(dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines. Some of these compounds inhibit growth of certain cancer cell lines. |
| doi_str_mv | 10.7124/bc.000A21 |
| format | Article |
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S. ; Pil’o, S. G. ; Zyabrev, V. S. ; Moskvina, V. S. ; Shablykina, O. V. ; Brovarets, V. S.</creator><creatorcontrib>Velihina, Ye. S. ; Pil’o, S. G. ; Zyabrev, V. S. ; Moskvina, V. S. ; Shablykina, O. V. ; Brovarets, V. S.</creatorcontrib><description>Aim. Synthesis of a series of 2-(dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines and evaluation in vitro of their anticancer activity against a panel of 60 cell lines derived from nine cancer types, namely leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, breast cancer. Methods. Organic synthesis; biological tests; spectral methods; statistical methods. Results. In vitro screening of the anticancer activity showed that 5 of 26 tested compounds can effectively inhibit the growth of certain cancer cell lines. Conclusions. New type of N-(2,2-dichloro-1-cyanoethenyl)carboxamides heterocyclization with 1H-pyrazol-5-amines led to the formation of 2-(dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines. Some of these compounds inhibit growth of certain cancer cell lines.</description><identifier>ISSN: 0233-7657</identifier><identifier>EISSN: 1993-6842</identifier><identifier>DOI: 10.7124/bc.000A21</identifier><language>eng</language><publisher>Kiev: Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine</publisher><subject>Amines ; Antitumor activity ; Breast cancer ; Cancer ; Colon cancer ; Kidney cancer ; Melanoma ; Non-small cell lung carcinoma ; Ovarian cancer ; Prostate cancer ; Small cell lung carcinoma ; Statistical analysis ; Tumor cell lines</subject><ispartof>Biopolimery i kletka, 2020, Vol.36 (1), p.60-73</ispartof><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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| subjects | Amines Antitumor activity Breast cancer Cancer Colon cancer Kidney cancer Melanoma Non-small cell lung carcinoma Ovarian cancer Prostate cancer Small cell lung carcinoma Statistical analysis Tumor cell lines |
| title | 2-(Dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines: synthesis and anticancer activity |
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