Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2

Nuclear envelope herniations (blebs) containing FG-nucleoporins and ubiquitin are the phenotypic hallmark of Torsin ATPase manipulation. Both the dynamics of blebbing and the connection to nuclear pore biogenesis remain poorly understood. We employ a proteomics-based approach to identify myeloid leu...

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Veröffentlicht in:	The Journal of cell biology 2020-06, Vol.219 (6), p.1
Hauptverfasser:	Rampello, Anthony J, Laudermilch, Ethan, Vishnoi, Nidhi, Prophet, Sarah M, Shao, Lin, Zhao, Chenguang, Lusk, C Patrick, Schlieker, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Biosynthesis Cell Cycle and Division Conjugation Disease Gene Knockout Techniques HeLa Cells Humans Intermediates Interphase Interphase - genetics Interphase - physiology Leukemia Membrane Glycoproteins - deficiency Membrane Glycoproteins - metabolism Microscopy, Electron, Transmission Mitosis Mitosis - genetics Mitosis - physiology Molecular Chaperones - chemistry Molecular Chaperones - genetics Molecular Chaperones - metabolism Myeloid leukemia Nuclear Envelope - genetics Nuclear Envelope - metabolism Nuclear Envelope - ultrastructure Nuclear membranes Nuclear Pore - metabolism Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleoporins Phenotypes Proteomics RNA, Small Interfering Ubiquitin Ubiquitin - chemistry Ubiquitin - metabolism
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