Immunomodulation‐Based Strategy for Improving Soft Tissue and Metal Implant Integration and Its Implications in the Development of Metal Soft Tissue Materials
The difficulties associated with metal implants and soft tissue integration have significantly affected the applications of metal implants in soft‐tissue‐related areas. Prompted by the close association between soft tissue integration and the immune response, an immunomodulation‐based strategy is pr...
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| Veröffentlicht in: | Advanced functional materials 2020-05, Vol.30 (21), p.n/a |
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| creator | Liu, Runheng Chen, Shoucheng Huang, Peina Liu, Guanqi Luo, Pu Li, Zhipeng Xiao, Yin Chen, Zhuofan Chen, Zetao |
| description | The difficulties associated with metal implants and soft tissue integration have significantly affected the applications of metal implants in soft‐tissue‐related areas. Prompted by the close association between soft tissue integration and the immune response, an immunomodulation‐based strategy is proposed to manipulate the immune microenvironment and improve metal implant–soft tissue integration. Considering their vital roles in soft tissue responses to metal implants, macrophages are used and the cytokines fingerprints of M1 and M2 macrophage immune microenvironments are evaluated for their potential modulatory effects on metal implant–soft tissue integration. The modulatory effects of different immune microenvironments on model soft tissue cells (human gingival epithelium cells) cultured on model metal implants (titanium alloy disks) are then described, with the underlying possible mechanism FAK‐AKT‐mTOR signaling unveiled. As further proof of concept, IL‐4/PDA (polydopamine)‐coated titanium alloy implants, aiming at modulating M2 macrophage polarization, are prepared and found to improve the in vivo metal implant‐soft tissue integration. It is the authors' ambition that this immunomodulation‐based strategy will change the negative perception and encourage the active development of metal materials with favorable soft tissue integration properties, thus improving the success rates of perforating metal implants and broadening their application in soft‐tissue‐related areas.
For the advancement of metal soft tissue materials, an immunomodulation‐based strategy is proposed to overcome the challenges of soft tissue and metal materials integration. The effects of macrophage‐mediated immune microenvironments on soft tissue and metal implant integration are unveiled. The M2 immune microenvironment is found to be more favorable for titanium alloy implant and epithelium tissue integration, possibly via activating the FAK‐AKT‐mTOR signaling. |
| doi_str_mv | 10.1002/adfm.201910672 |
| format | Article |
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For the advancement of metal soft tissue materials, an immunomodulation‐based strategy is proposed to overcome the challenges of soft tissue and metal materials integration. The effects of macrophage‐mediated immune microenvironments on soft tissue and metal implant integration are unveiled. The M2 immune microenvironment is found to be more favorable for titanium alloy implant and epithelium tissue integration, possibly via activating the FAK‐AKT‐mTOR signaling.</description><identifier>ISSN: 1616-301X</identifier><identifier>EISSN: 1616-3028</identifier><identifier>DOI: 10.1002/adfm.201910672</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Cytokines ; Disks ; Epithelium ; immune modulation ; Immune system ; Macrophages ; Materials science ; metal implants ; Perforating ; soft tissue ; Soft tissues ; Strategy ; Surgical implants ; tissue regeneration ; Titanium alloys ; Titanium base alloys ; Transplants & implants</subject><ispartof>Advanced functional materials, 2020-05, Vol.30 (21), p.n/a</ispartof><rights>2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3172-ae6e93180c6abbba573264a6ed79dcbd90dee6a39c1b0becc379d4db047e07693</citedby><cites>FETCH-LOGICAL-c3172-ae6e93180c6abbba573264a6ed79dcbd90dee6a39c1b0becc379d4db047e07693</cites><orcidid>0000-0001-8344-2602 ; 0000-0002-8662-1849</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadfm.201910672$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadfm.201910672$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Liu, Runheng</creatorcontrib><creatorcontrib>Chen, Shoucheng</creatorcontrib><creatorcontrib>Huang, Peina</creatorcontrib><creatorcontrib>Liu, Guanqi</creatorcontrib><creatorcontrib>Luo, Pu</creatorcontrib><creatorcontrib>Li, Zhipeng</creatorcontrib><creatorcontrib>Xiao, Yin</creatorcontrib><creatorcontrib>Chen, Zhuofan</creatorcontrib><creatorcontrib>Chen, Zetao</creatorcontrib><title>Immunomodulation‐Based Strategy for Improving Soft Tissue and Metal Implant Integration and Its Implications in the Development of Metal Soft Tissue Materials</title><title>Advanced functional materials</title><description>The difficulties associated with metal implants and soft tissue integration have significantly affected the applications of metal implants in soft‐tissue‐related areas. Prompted by the close association between soft tissue integration and the immune response, an immunomodulation‐based strategy is proposed to manipulate the immune microenvironment and improve metal implant–soft tissue integration. Considering their vital roles in soft tissue responses to metal implants, macrophages are used and the cytokines fingerprints of M1 and M2 macrophage immune microenvironments are evaluated for their potential modulatory effects on metal implant–soft tissue integration. The modulatory effects of different immune microenvironments on model soft tissue cells (human gingival epithelium cells) cultured on model metal implants (titanium alloy disks) are then described, with the underlying possible mechanism FAK‐AKT‐mTOR signaling unveiled. As further proof of concept, IL‐4/PDA (polydopamine)‐coated titanium alloy implants, aiming at modulating M2 macrophage polarization, are prepared and found to improve the in vivo metal implant‐soft tissue integration. It is the authors' ambition that this immunomodulation‐based strategy will change the negative perception and encourage the active development of metal materials with favorable soft tissue integration properties, thus improving the success rates of perforating metal implants and broadening their application in soft‐tissue‐related areas.
For the advancement of metal soft tissue materials, an immunomodulation‐based strategy is proposed to overcome the challenges of soft tissue and metal materials integration. The effects of macrophage‐mediated immune microenvironments on soft tissue and metal implant integration are unveiled. The M2 immune microenvironment is found to be more favorable for titanium alloy implant and epithelium tissue integration, possibly via activating the FAK‐AKT‐mTOR signaling.</description><subject>Cytokines</subject><subject>Disks</subject><subject>Epithelium</subject><subject>immune modulation</subject><subject>Immune system</subject><subject>Macrophages</subject><subject>Materials science</subject><subject>metal implants</subject><subject>Perforating</subject><subject>soft tissue</subject><subject>Soft tissues</subject><subject>Strategy</subject><subject>Surgical implants</subject><subject>tissue regeneration</subject><subject>Titanium alloys</subject><subject>Titanium base alloys</subject><subject>Transplants & implants</subject><issn>1616-301X</issn><issn>1616-3028</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkbFOwzAURSMEEqWwMltiTrHj1GnG0lKI1IqhRWKLnPilpErsYjtF3fgEPoFv40tw06qwMT3r3Xvuk3U975rgHsE4uOWiqHsBJjHBLApOvA5hhPkUB4PT45u8nHsXxqwwJlFEw473ldR1I1WtRFNxWyr5_fF5xw0INLeaW1huUaE0Suq1VptSLtFcFRYtSmMaQFwKNAPLq51ecWlRIh2i26BWTaxptTJvdwaVEtlXQGPYQKXWNThGFYeQv9Ezd1uXvDKX3lnhBlwdZtd7ntwvRo_-9OkhGQ2nfk5JFPgcGMSUDHDOeJZlvB_RgIWcgYhikWcixgKAcRrnJMMZ5Dl1-1BkOIwARyymXe9mn-s--taAselKNVq6k2kQ4rDPQhZS5-rtXblWxmgo0rUua663KcHproV010J6bMEB8R54LyvY_uNOh-PJ7Jf9AQ8IkKk</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Liu, Runheng</creator><creator>Chen, Shoucheng</creator><creator>Huang, Peina</creator><creator>Liu, Guanqi</creator><creator>Luo, Pu</creator><creator>Li, Zhipeng</creator><creator>Xiao, Yin</creator><creator>Chen, Zhuofan</creator><creator>Chen, Zetao</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0001-8344-2602</orcidid><orcidid>https://orcid.org/0000-0002-8662-1849</orcidid></search><sort><creationdate>20200501</creationdate><title>Immunomodulation‐Based Strategy for Improving Soft Tissue and Metal Implant Integration and Its Implications in the Development of Metal Soft Tissue Materials</title><author>Liu, Runheng ; Chen, Shoucheng ; Huang, Peina ; Liu, Guanqi ; Luo, Pu ; Li, Zhipeng ; Xiao, Yin ; Chen, Zhuofan ; Chen, Zetao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3172-ae6e93180c6abbba573264a6ed79dcbd90dee6a39c1b0becc379d4db047e07693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cytokines</topic><topic>Disks</topic><topic>Epithelium</topic><topic>immune modulation</topic><topic>Immune system</topic><topic>Macrophages</topic><topic>Materials science</topic><topic>metal implants</topic><topic>Perforating</topic><topic>soft tissue</topic><topic>Soft tissues</topic><topic>Strategy</topic><topic>Surgical implants</topic><topic>tissue regeneration</topic><topic>Titanium alloys</topic><topic>Titanium base alloys</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Runheng</creatorcontrib><creatorcontrib>Chen, Shoucheng</creatorcontrib><creatorcontrib>Huang, Peina</creatorcontrib><creatorcontrib>Liu, Guanqi</creatorcontrib><creatorcontrib>Luo, Pu</creatorcontrib><creatorcontrib>Li, Zhipeng</creatorcontrib><creatorcontrib>Xiao, Yin</creatorcontrib><creatorcontrib>Chen, Zhuofan</creatorcontrib><creatorcontrib>Chen, Zetao</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Advanced functional materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Runheng</au><au>Chen, Shoucheng</au><au>Huang, Peina</au><au>Liu, Guanqi</au><au>Luo, Pu</au><au>Li, Zhipeng</au><au>Xiao, Yin</au><au>Chen, Zhuofan</au><au>Chen, Zetao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulation‐Based Strategy for Improving Soft Tissue and Metal Implant Integration and Its Implications in the Development of Metal Soft Tissue Materials</atitle><jtitle>Advanced functional materials</jtitle><date>2020-05-01</date><risdate>2020</risdate><volume>30</volume><issue>21</issue><epage>n/a</epage><issn>1616-301X</issn><eissn>1616-3028</eissn><abstract>The difficulties associated with metal implants and soft tissue integration have significantly affected the applications of metal implants in soft‐tissue‐related areas. Prompted by the close association between soft tissue integration and the immune response, an immunomodulation‐based strategy is proposed to manipulate the immune microenvironment and improve metal implant–soft tissue integration. Considering their vital roles in soft tissue responses to metal implants, macrophages are used and the cytokines fingerprints of M1 and M2 macrophage immune microenvironments are evaluated for their potential modulatory effects on metal implant–soft tissue integration. The modulatory effects of different immune microenvironments on model soft tissue cells (human gingival epithelium cells) cultured on model metal implants (titanium alloy disks) are then described, with the underlying possible mechanism FAK‐AKT‐mTOR signaling unveiled. As further proof of concept, IL‐4/PDA (polydopamine)‐coated titanium alloy implants, aiming at modulating M2 macrophage polarization, are prepared and found to improve the in vivo metal implant‐soft tissue integration. It is the authors' ambition that this immunomodulation‐based strategy will change the negative perception and encourage the active development of metal materials with favorable soft tissue integration properties, thus improving the success rates of perforating metal implants and broadening their application in soft‐tissue‐related areas.
For the advancement of metal soft tissue materials, an immunomodulation‐based strategy is proposed to overcome the challenges of soft tissue and metal materials integration. The effects of macrophage‐mediated immune microenvironments on soft tissue and metal implant integration are unveiled. The M2 immune microenvironment is found to be more favorable for titanium alloy implant and epithelium tissue integration, possibly via activating the FAK‐AKT‐mTOR signaling.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/adfm.201910672</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-8344-2602</orcidid><orcidid>https://orcid.org/0000-0002-8662-1849</orcidid></addata></record> |
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| subjects | Cytokines Disks Epithelium immune modulation Immune system Macrophages Materials science metal implants Perforating soft tissue Soft tissues Strategy Surgical implants tissue regeneration Titanium alloys Titanium base alloys Transplants & implants |
| title | Immunomodulation‐Based Strategy for Improving Soft Tissue and Metal Implant Integration and Its Implications in the Development of Metal Soft Tissue Materials |
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