O-linked beta-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1

O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) is the only enzyme catalyzing O-GlcNAcylation. Although it has been shown that OGT plays an essential role in maintaining postnatal heart function, its role in heart development remains unknown. Here we showed that loss of OGT in early fetal ca...

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Veröffentlicht in:	PLoS genetics 2020-04, Vol.16 (4), p.e1008730, Article 1008730
Hauptverfasser:	Mu, Yongxin, Yu, Houzhi, Wu, Tongbin, Zhang, Jianlin, Evans, Sylvia M., Chen, Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin Angiopoietin-1 - genetics Angiopoietin-1 - metabolism Animals Antibodies Biology and Life Sciences Cardiology Cardiomyocytes Cells, Cultured Defects Embryos Fetuses Genetics & Heredity Heart Heart - embryology Heart - physiology Heart failure Histology Ischemia Kinases Laboratory animals Life Sciences & Biomedicine Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Myocytes, Cardiac - metabolism N-Acetylglucosamine N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism O-GlcNAcylation Proteins Research and Analysis Methods Ribonucleic acid RNA Science & Technology Ventricle
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