Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)
An aspirin-ligated cisplatin derivative, biasplatin, was prepared from acetylsalicylic anhydride and oxoplatin in DMF. Biasplatin was synthesized from oxoplatin and aspirin anhydride as starting materials by a substitution reaction of hydroxo leaving groups in its axial position. The obtained biaspl...
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| Veröffentlicht in: | Chemical papers 2020-08, Vol.74 (8), p.2733-2741 |
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| creator | Rosari, Venansia Avelia Lestari, Witri Wahyu Firdaus, Maulidan |
| description | An aspirin-ligated cisplatin derivative, biasplatin, was prepared from acetylsalicylic anhydride and oxoplatin in DMF. Biasplatin was synthesized from oxoplatin and aspirin anhydride as starting materials by a substitution reaction of hydroxo leaving groups in its axial position. The obtained biasplatin was fully characterized by FTIR,
1
HNMR,
13
CNMR, and ESI mass spectroscopy. Biasplatin entrapped into MIL-101(Fe) by suspended in DMF and stirring for 72 h at ambient temperature, known as biasplatin@MIL-101(Fe). The slow release of biasplatin and biasplatin@MIL-101(Fe) was conducted in PBS solution pH 7.20, 37 °C as media and measured by UV–Vis spectrophotometer. The release of biasplatin without loaded into MIL-101(Fe) is persistent for 3%, and biasplatin@MIL-101(Fe) is 0.05% over 72 h. A significant slow release of biasplatin@MIL-101(Fe) only 1% compared with time release of biasplatin without loaded into MIL-101(Fe). |
| doi_str_mv | 10.1007/s11696-020-01114-4 |
| format | Article |
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1
HNMR,
13
CNMR, and ESI mass spectroscopy. Biasplatin entrapped into MIL-101(Fe) by suspended in DMF and stirring for 72 h at ambient temperature, known as biasplatin@MIL-101(Fe). The slow release of biasplatin and biasplatin@MIL-101(Fe) was conducted in PBS solution pH 7.20, 37 °C as media and measured by UV–Vis spectrophotometer. The release of biasplatin without loaded into MIL-101(Fe) is persistent for 3%, and biasplatin@MIL-101(Fe) is 0.05% over 72 h. A significant slow release of biasplatin@MIL-101(Fe) only 1% compared with time release of biasplatin without loaded into MIL-101(Fe).</description><identifier>ISSN: 2585-7290</identifier><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>DOI: 10.1007/s11696-020-01114-4</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Ambient temperature ; Anhydrides ; Aspirin ; Biochemistry ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Industrial Chemistry/Chemical Engineering ; Materials Science ; Medicinal Chemistry ; Original Paper ; Substitution reactions</subject><ispartof>Chemical papers, 2020-08, Vol.74 (8), p.2733-2741</ispartof><rights>Institute of Chemistry, Slovak Academy of Sciences 2020</rights><rights>Institute of Chemistry, Slovak Academy of Sciences 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-65240bd51d94313464b053fe108ba5d346cbb1ba19bec36726614e6f6d548f3f3</citedby><cites>FETCH-LOGICAL-c422t-65240bd51d94313464b053fe108ba5d346cbb1ba19bec36726614e6f6d548f3f3</cites><orcidid>0000-0003-1005-5374</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11696-020-01114-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11696-020-01114-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids></links><search><creatorcontrib>Rosari, Venansia Avelia</creatorcontrib><creatorcontrib>Lestari, Witri Wahyu</creatorcontrib><creatorcontrib>Firdaus, Maulidan</creatorcontrib><title>Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)</title><title>Chemical papers</title><addtitle>Chem. Pap</addtitle><description>An aspirin-ligated cisplatin derivative, biasplatin, was prepared from acetylsalicylic anhydride and oxoplatin in DMF. Biasplatin was synthesized from oxoplatin and aspirin anhydride as starting materials by a substitution reaction of hydroxo leaving groups in its axial position. The obtained biasplatin was fully characterized by FTIR,
1
HNMR,
13
CNMR, and ESI mass spectroscopy. Biasplatin entrapped into MIL-101(Fe) by suspended in DMF and stirring for 72 h at ambient temperature, known as biasplatin@MIL-101(Fe). The slow release of biasplatin and biasplatin@MIL-101(Fe) was conducted in PBS solution pH 7.20, 37 °C as media and measured by UV–Vis spectrophotometer. The release of biasplatin without loaded into MIL-101(Fe) is persistent for 3%, and biasplatin@MIL-101(Fe) is 0.05% over 72 h. A significant slow release of biasplatin@MIL-101(Fe) only 1% compared with time release of biasplatin without loaded into MIL-101(Fe).</description><subject>Ambient temperature</subject><subject>Anhydrides</subject><subject>Aspirin</subject><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Original Paper</subject><subject>Substitution reactions</subject><issn>2585-7290</issn><issn>0366-6352</issn><issn>1336-9075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1Lw0AQhhdRsNT-AU8LXvSwurNfSY5SrBYqHtSry26yqSsxqTtppf_eaARvnmYYnvcdeAg5BX4JnGdXCGAKw7jgjAOAYuqATEBKwwqe6UMyETrXLBMFPyYzxOi5UpkUuckm5OVx3_avASPSrqYONzHFljVx7fpQ0TLipnF9bGkVUtwN2y4gdW1FY48Um-6TptAEh4Fiv632tNuFRO-XKwYczhfh4oQc1a7BMPudU_K8uHma37HVw-1yfr1ipRKiZ0YLxX2loSqUBKmM8lzLOgDPvdPVcCi9B--g8KGUJhPGgAqmNpVWeS1rOSVnY-8mdR_bgL1967apHV7aoVlmmSyEGigxUmXqEFOo7SbFd5f2Frj9VmlHlXZQaX9U2u-QHEM4wO06pL_qf1JfqYx1dQ</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Rosari, Venansia Avelia</creator><creator>Lestari, Witri Wahyu</creator><creator>Firdaus, Maulidan</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0003-1005-5374</orcidid></search><sort><creationdate>20200801</creationdate><title>Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)</title><author>Rosari, Venansia Avelia ; Lestari, Witri Wahyu ; Firdaus, Maulidan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-65240bd51d94313464b053fe108ba5d346cbb1ba19bec36726614e6f6d548f3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Ambient temperature</topic><topic>Anhydrides</topic><topic>Aspirin</topic><topic>Biochemistry</topic><topic>Biotechnology</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Original Paper</topic><topic>Substitution reactions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosari, Venansia Avelia</creatorcontrib><creatorcontrib>Lestari, Witri Wahyu</creatorcontrib><creatorcontrib>Firdaus, Maulidan</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosari, Venansia Avelia</au><au>Lestari, Witri Wahyu</au><au>Firdaus, Maulidan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2020-08-01</date><risdate>2020</risdate><volume>74</volume><issue>8</issue><spage>2733</spage><epage>2741</epage><pages>2733-2741</pages><issn>2585-7290</issn><issn>0366-6352</issn><eissn>1336-9075</eissn><abstract>An aspirin-ligated cisplatin derivative, biasplatin, was prepared from acetylsalicylic anhydride and oxoplatin in DMF. Biasplatin was synthesized from oxoplatin and aspirin anhydride as starting materials by a substitution reaction of hydroxo leaving groups in its axial position. The obtained biasplatin was fully characterized by FTIR,
1
HNMR,
13
CNMR, and ESI mass spectroscopy. Biasplatin entrapped into MIL-101(Fe) by suspended in DMF and stirring for 72 h at ambient temperature, known as biasplatin@MIL-101(Fe). The slow release of biasplatin and biasplatin@MIL-101(Fe) was conducted in PBS solution pH 7.20, 37 °C as media and measured by UV–Vis spectrophotometer. The release of biasplatin without loaded into MIL-101(Fe) is persistent for 3%, and biasplatin@MIL-101(Fe) is 0.05% over 72 h. A significant slow release of biasplatin@MIL-101(Fe) only 1% compared with time release of biasplatin without loaded into MIL-101(Fe).</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11696-020-01114-4</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1005-5374</orcidid></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Ambient temperature Anhydrides Aspirin Biochemistry Biotechnology Chemistry Chemistry and Materials Science Chemistry/Food Science Industrial Chemistry/Chemical Engineering Materials Science Medicinal Chemistry Original Paper Substitution reactions |
| title | Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe) |
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