Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review

IMPORTANCE: The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs for prevention and treatment. Given the rapid pace of scientific discovery and clinical dat...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2020-05, Vol.323 (18), p.1824-1836
Hauptverfasser:	Sanders, James M, Monogue, Marguerite L, Jodlowski, Tomasz Z, Cutrell, James B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - therapeutic use Adrenal Cortex Hormones - therapeutic use Alanine - analogs & derivatives Alanine - therapeutic use Amides - therapeutic use Angiotensin Angiotensin Receptor Antagonists - therapeutic use Angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antiviral Agents - therapeutic use Azithromycin - therapeutic use Betacoronavirus - drug effects Betacoronavirus - physiology Chloroquine - therapeutic use Clinical trials Coronaviridae Coronavirus Infections - drug therapy Coronavirus Infections - epidemiology Coronaviruses Corticoids Corticosteroids COVID-19 Enzyme inhibitors FDA approval Humans Hydroxychloroquine - therapeutic use Immunoglobulins - therapeutic use Immunologic Factors - therapeutic use Indoles - therapeutic use Influenza Lopinavir - therapeutic use Medical treatment Oseltamivir Oseltamivir - therapeutic use Pandemics Peptidyl-dipeptidase A Pneumonia, Viral - drug therapy Pneumonia, Viral - epidemiology Public health Pyrazines - therapeutic use Respiratory diseases Ribavirin - therapeutic use Ritonavir - therapeutic use SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Therapeutic targets Viral diseases Viruses Withholding Treatment
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