Physicochemical and Immune Properties of Glycoglycerolipids from Laminaria japonicain Immunostimulating Complexes (ISCOMs)
Certain physicochemical properties of glycoglycerolipids from marine alga Laminaria japonica (monogalactosyldiacylglycerol, digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol) and their ability to be incorporated into immunostimulating complexes (ISCOMs) used for delivery of microbial and...
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| Veröffentlicht in: | Biology bulletin of the Russian Academy of Sciences 2004-01, Vol.31 (3), p.244-249 |
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| container_title | Biology bulletin of the Russian Academy of Sciences |
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| creator | Li, I A Popov, A M Sanina, N M Ya, Kostetskii E Novikova, O D Reunov, A V Nagorskaya, V P Yu, Portnyagina O Khomenko, V A Shnyrov, V L |
| description | Certain physicochemical properties of glycoglycerolipids from marine alga Laminaria japonica (monogalactosyldiacylglycerol, digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol) and their ability to be incorporated into immunostimulating complexes (ISCOMs) used for delivery of microbial and tumor antigens in vesicular form were comparatively described. These glycolipids proved to considerably differ by fatty acid composition, degree of unsaturation, and phase transition temperatures. Production of modified ISCOMs through incorporation of these glycolipids into the vesicle instead of the glycolipid component was demonstrated. Preliminary data demonstrated no significant increase in immune response to Yersinia pseudotuberculosis porin in the modified (with monogalactosyldiacylglycerol) and classical (with phosphatidylcholine) ISCOMs as compared to pure porin. |
| doi_str_mv | 10.1023/B:BIBU.0000030144.98256.ee |
| format | Article |
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These glycolipids proved to considerably differ by fatty acid composition, degree of unsaturation, and phase transition temperatures. Production of modified ISCOMs through incorporation of these glycolipids into the vesicle instead of the glycolipid component was demonstrated. Preliminary data demonstrated no significant increase in immune response to Yersinia pseudotuberculosis porin in the modified (with monogalactosyldiacylglycerol) and classical (with phosphatidylcholine) ISCOMs as compared to pure porin.</description><identifier>ISSN: 1062-3590</identifier><identifier>EISSN: 1608-3059</identifier><identifier>DOI: 10.1023/B:BIBU.0000030144.98256.ee</identifier><language>eng</language><publisher>New York: Springer Nature B.V</publisher><subject>Antigen (tumor-associated) ; Fatty acid composition ; Glycolipids ; Immune response ; ISCOMS ; Lecithin ; Phase transitions ; Phosphatidylcholine ; Physicochemical properties ; Pseudotuberculosis</subject><ispartof>Biology bulletin of the Russian Academy of Sciences, 2004-01, Vol.31 (3), p.244-249</ispartof><rights>MAIK “Nauka/Interperiodica” 2004.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Li, I A</creatorcontrib><creatorcontrib>Popov, A M</creatorcontrib><creatorcontrib>Sanina, N M</creatorcontrib><creatorcontrib>Ya, Kostetskii E</creatorcontrib><creatorcontrib>Novikova, O D</creatorcontrib><creatorcontrib>Reunov, A V</creatorcontrib><creatorcontrib>Nagorskaya, V P</creatorcontrib><creatorcontrib>Yu, Portnyagina O</creatorcontrib><creatorcontrib>Khomenko, V A</creatorcontrib><creatorcontrib>Shnyrov, V L</creatorcontrib><title>Physicochemical and Immune Properties of Glycoglycerolipids from Laminaria japonicain Immunostimulating Complexes (ISCOMs)</title><title>Biology bulletin of the Russian Academy of Sciences</title><description>Certain physicochemical properties of glycoglycerolipids from marine alga Laminaria japonica (monogalactosyldiacylglycerol, digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol) and their ability to be incorporated into immunostimulating complexes (ISCOMs) used for delivery of microbial and tumor antigens in vesicular form were comparatively described. These glycolipids proved to considerably differ by fatty acid composition, degree of unsaturation, and phase transition temperatures. Production of modified ISCOMs through incorporation of these glycolipids into the vesicle instead of the glycolipid component was demonstrated. Preliminary data demonstrated no significant increase in immune response to Yersinia pseudotuberculosis porin in the modified (with monogalactosyldiacylglycerol) and classical (with phosphatidylcholine) ISCOMs as compared to pure porin.</description><subject>Antigen (tumor-associated)</subject><subject>Fatty acid composition</subject><subject>Glycolipids</subject><subject>Immune response</subject><subject>ISCOMS</subject><subject>Lecithin</subject><subject>Phase transitions</subject><subject>Phosphatidylcholine</subject><subject>Physicochemical properties</subject><subject>Pseudotuberculosis</subject><issn>1062-3590</issn><issn>1608-3059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqNjM1KxDAcxIMouH68Q9CLHlrz1dp6bFm1oLignpfQTXdTkvxj0oLr0xvRB3AOMwMz_BC6oCSnhPGb5q7pmvec_IgTKkReV6woc6UO0IKWpMo4KerD1EnJMl7U5BidxDimu-CCLdDXarePuod-p6zupcHSbXBn7ewUXgXwKkxaRQwDfjD7HrbJVACjvd5EPASw-Ela7WTQEo_Sg0sQ7X4JECdtZyMn7ba4BeuN-kysq-61fXmO12foaJAmqvO_PEWX98u39jHzAT5mFaf1CHNwaVozQTilt6Iq-f9e3_NLWBA</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Li, I A</creator><creator>Popov, A M</creator><creator>Sanina, N M</creator><creator>Ya, Kostetskii E</creator><creator>Novikova, O D</creator><creator>Reunov, A V</creator><creator>Nagorskaya, V P</creator><creator>Yu, Portnyagina O</creator><creator>Khomenko, V A</creator><creator>Shnyrov, V L</creator><general>Springer Nature B.V</general><scope/></search><sort><creationdate>20040101</creationdate><title>Physicochemical and Immune Properties of Glycoglycerolipids from Laminaria japonicain Immunostimulating Complexes (ISCOMs)</title><author>Li, I A ; Popov, A M ; Sanina, N M ; Ya, Kostetskii E ; Novikova, O D ; Reunov, A V ; Nagorskaya, V P ; Yu, Portnyagina O ; Khomenko, V A ; Shnyrov, V L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_24031174863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antigen (tumor-associated)</topic><topic>Fatty acid composition</topic><topic>Glycolipids</topic><topic>Immune response</topic><topic>ISCOMS</topic><topic>Lecithin</topic><topic>Phase transitions</topic><topic>Phosphatidylcholine</topic><topic>Physicochemical properties</topic><topic>Pseudotuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, I A</creatorcontrib><creatorcontrib>Popov, A M</creatorcontrib><creatorcontrib>Sanina, N M</creatorcontrib><creatorcontrib>Ya, Kostetskii E</creatorcontrib><creatorcontrib>Novikova, O D</creatorcontrib><creatorcontrib>Reunov, A V</creatorcontrib><creatorcontrib>Nagorskaya, V P</creatorcontrib><creatorcontrib>Yu, Portnyagina O</creatorcontrib><creatorcontrib>Khomenko, V A</creatorcontrib><creatorcontrib>Shnyrov, V L</creatorcontrib><jtitle>Biology bulletin of the Russian Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, I A</au><au>Popov, A M</au><au>Sanina, N M</au><au>Ya, Kostetskii E</au><au>Novikova, O D</au><au>Reunov, A V</au><au>Nagorskaya, V P</au><au>Yu, Portnyagina O</au><au>Khomenko, V A</au><au>Shnyrov, V L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physicochemical and Immune Properties of Glycoglycerolipids from Laminaria japonicain Immunostimulating Complexes (ISCOMs)</atitle><jtitle>Biology bulletin of the Russian Academy of Sciences</jtitle><date>2004-01-01</date><risdate>2004</risdate><volume>31</volume><issue>3</issue><spage>244</spage><epage>249</epage><pages>244-249</pages><issn>1062-3590</issn><eissn>1608-3059</eissn><abstract>Certain physicochemical properties of glycoglycerolipids from marine alga Laminaria japonica (monogalactosyldiacylglycerol, digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol) and their ability to be incorporated into immunostimulating complexes (ISCOMs) used for delivery of microbial and tumor antigens in vesicular form were comparatively described. 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| subjects | Antigen (tumor-associated) Fatty acid composition Glycolipids Immune response ISCOMS Lecithin Phase transitions Phosphatidylcholine Physicochemical properties Pseudotuberculosis |
| title | Physicochemical and Immune Properties of Glycoglycerolipids from Laminaria japonicain Immunostimulating Complexes (ISCOMs) |
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