Lactobacillus rhamnosus GG Attenuates Lipopolysaccharide-Induced Inflammation and Barrier Dysfunction by Regulating MAPK/NF-κB Signaling and Modulating Metabolome in the Piglet Intestine

ABSTRACT Background Probiotic Lactobacillius rhamnosus GG (LGG) shows beneficial immunomodulation on cultured cell lines in vitro and in mouse models. Objective The aim was to investigate the effects of LGG on intestinal injury and the underlying mechanisms by elucidating inflammatory signaling path...

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Veröffentlicht in:	The Journal of nutrition 2020-05, Vol.150 (5), p.1313-1323
Hauptverfasser:	Mao, Jiangdi, Qi, Siri, Cui, Yanjun, Dou, Xiaoxiao, Luo, Xin M, Liu, Jianxin, Zhu, Tao, Ma, Yanfei, Wang, Haifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Body weight Cell lines Erythritol Ethanolamine Extracellular signal-regulated kinase Female Gastroenteritis - chemically induced Gastroenteritis - prevention & control Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - prevention & control Hogs Immunomodulation Inflammation Injection Inoculation Interleukin 6 Intestine Kinases Lacticaseibacillus rhamnosus - physiology Lactobacilli Lipopolysaccharides Lipopolysaccharides - pharmacology Male MAP kinase MAP Kinase Signaling System - physiology Metabolism Metabolites Metabolome - physiology NF-κB protein Octanoic acid Olein p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Pretreatment Probiotics Probiotics - administration & dosage Protein kinase Proteins Signal Transduction - physiology Signaling Stimulation Sus scrofa Tight Junction Proteins - genetics Transcription Factor RelA - metabolism Tumor necrosis factor-α Up-Regulation - physiology Xylose Zonula occludens-1 protein
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