A dearomative ipso-iodocyclization/desymmetrization sequence leading to optically active tricyclic piperazine scaffolds

Dearomative ipso-iodocyclization of 4-(1-ethoxyethoxy)-N-propargylanilines leading to 1-azaspiro[4.5]deca-3,6,9-trien-8-ones has been developed. This reaction is characterized by the yield of fewer toxic byproducts and is conducted by a more user-friendly protocol compared to other reported methods....

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Veröffentlicht in:	Organic & biomolecular chemistry 2020-05, Vol.18 (18), p.3501-3511
Hauptverfasser:	Okitsu, Takashi, Horike, Arisa, Shimazawa, Natsumi, Wada, Akimori
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids NMR Nuclear magnetic resonance Optical activity Piperazine Scaffolds Stereoselectivity Substrates
Online-Zugang:	Volltext
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