Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells

The cGAS-STING pathway is a major mechanism that mammalian cells utilize to detect cytoplasmic dsDNA from incoming viruses, bacteria, or self. CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor protein that directly binds dsDNAs. cGAS synthesizes cyclic GMP-AMP (cGAMP), which binds to the adaptor STIMULAT...

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Veröffentlicht in:	Scientific reports 2020-05, Vol.10 (1), p.7604, Article 7604
Hauptverfasser:	Wiser, Caroline, Kim, Byungil, Vincent, Jessica, Ascano, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/556 631/250/262/2106 AMP Animals Autoimmune diseases Benzofurans - pharmacology Cell Line Cell lines Cyclic GMP Cytokines - genetics Cytokines - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Gene Expression Regulation - drug effects Humanities and Social Sciences Humans Immune response Immunomodulation - drug effects Innate immunity Interferon Interferon regulatory factor Interferon regulatory factor 3 Mammalian cells Membrane Proteins - metabolism Mice Models, Biological Monocytes - drug effects Monocytes - immunology Monocytes - metabolism multidisciplinary Nucleotides, Cyclic - metabolism Nucleotidyltransferases - antagonists & inhibitors Nucleotidyltransferases - metabolism Receptors, Pattern Recognition - genetics Receptors, Pattern Recognition - metabolism Ribonucleic acid RNA Science Science (multidisciplinary) Signal Transduction - drug effects Toll-like receptors
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