Site-Specific Conjugation of Native Antibodies Using Engineered Microbial Transglutaminases

Site-specific bioconjugation technologies are frequently employed to generate homogeneous antibody–drug conjugates (ADCs) and are generally considered superior to stochastic approaches like lysine coupling. However, most of the technologies developed so far require undesired manipulation of the anti...

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Veröffentlicht in:	Bioconjugate chemistry 2020-04, Vol.31 (4), p.1070-1076
Hauptverfasser:	Dickgiesser, Stephan, Rieker, Marcel, Mueller-Pompalla, Dirk, Schröter, Christian, Tonillo, Jason, Warszawski, Shira, Raab-Westphal, Sabine, Kühn, Stefanie, Knehans, Tim, Könning, Doreen, Dotterweich, Julia, Betz, Ulrich A. K, Anderl, Jan, Hecht, Stefan, Rasche, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Binding Sites Conjugation Glycan Immunoconjugates - metabolism Immunoglobulin G Immunoglobulins Lysine Microorganisms Protein Engineering Streptomyces - enzymology Transglutaminases - chemistry Transglutaminases - genetics Transglutaminases - metabolism
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