Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of Youth

Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin (PI) in the endoplasmic reticulum (ER) drive the molecular pathogenesis of mutant gene-induced diabetes of youth (MIDY). How these abnormal interactions are initiated remains unknown. Normally, PI-WT dimerizes in the ER. He...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2020-05, Vol.69 (5), p.954-964
Hauptverfasser:	Sun, Jinhong, Xiong, Yi, Li, Xin, Haataja, Leena, Chen, Wei, Mir, Saiful A, Lv, Li, Madley, Rachel, Larkin, Dennis, Anjum, Arfah, Dhayalan, Balamurugan, Rege, Nischay, Wickramasinghe, Nalinda P, Weiss, Michael A, Itkin-Ansari, Pamela, Kaufman, Randal J, Ostrov, David A, Arvan, Peter, Liu, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells Cell Line Diabetes Diabetes mellitus Dimerization Endoplasmic reticulum Humans INS gene Insulin Insulin - chemical synthesis Insulin - chemistry Insulin - genetics Insulin - metabolism Islet Studies Islets of Langerhans Mice Models, Molecular Mutants Mutation Proinsulin - chemistry Proinsulin - genetics Proinsulin - metabolism Protein Conformation Self-association Therapeutic applications Tyrosine
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