Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone

Catechol O-methyltransferase (COMT) is known as an important drug-target protein in the field of Parkinson’s disease. All clinically approved COMT inhibitors bring a 5-substituted-3-nitrocatechol ring as a pharmacophore, and they bind to COMT with S-adenosylmethionine (SAM) and an Mg2+ ion to form a...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2020/05/01, Vol.68(5), pp.447-451
Hauptverfasser:	Iijima, Hiroshi, Takebe, Katsuki, Suzuki, Mamoru, Kobayashi, Hiroko, Takamiya, Tomoko, Saito, Hiroaki, Niwa, Norio, Kuwada-Kusunose, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosylmethionine Catechol Catechol O-methyltransferase Catechol O-Methyltransferase - isolation & purification Catechol O-Methyltransferase - metabolism Catechol O-Methyltransferase Inhibitors - chemical synthesis Catechol O-Methyltransferase Inhibitors - chemistry Catechol O-Methyltransferase Inhibitors - pharmacology Catechols - chemical synthesis Catechols - chemistry Catechols - pharmacology Crystal structure Crystallography Crystallography, X-Ray Dose-Response Relationship, Drug Humans Information processing Inhibitors Magnesium Methyltransferase Models, Molecular Molecular Structure Movement disorders Neurodegenerative diseases nitecapone Parkinson's disease Pentanones - chemical synthesis Pentanones - chemistry Pentanones - pharmacology Protein structure Proteins S-Adenosylmethionine Structure-Activity Relationship Therapeutic targets
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