Factors influencing the reduction in corneal endothelial cells after Ex-Press® surgery
Purpose We investigated the factors that influence the reduction in corneal endothelial cells after Ex-Press ® surgery. Methods This was a retrospective study. We included patients who had undergone Ex-Press surgery and were followed up for > 2. We analyzed the corneal endothelial cell density (E...
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| Veröffentlicht in: | International ophthalmology 2020-05, Vol.40 (5), p.1201-1208 |
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| creator | Tojo, Naoki Numata, Ayaka Hayashi, Atsushi |
| description | Purpose
We investigated the factors that influence the reduction in corneal endothelial cells after Ex-Press
®
surgery.
Methods
This was a retrospective study. We included patients who had undergone Ex-Press surgery and were followed up for > 2. We analyzed the corneal endothelial cell density (ECD) before and after Ex-Press surgery. We investigated the insertion position (Ex-Press device was inserted into cornea or trabecular meshwork (TM)), Ex-Press–iris touch, cornea–iris touch, peripheral anterior synechiae, history of trabeculotomy, history of selective laser trabeculoplasty, type of glaucoma, and simultaneous cataract surgery as influencing factors. We used multivariate analysis to determine the factors influencing the reduction rate of ECD.
Results
We included 129 eyes. The mean of ECD had decreased 7.0% at 2 years. Ex-Press surgeries significantly decreased the ECD after 2 years (
p
= 0.0118). As a result of the multivariate analysis, the factor that led to a significantly faster reduction in ECD was the insertion position of the Ex-Press (
p
|
| doi_str_mv | 10.1007/s10792-020-01286-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2396578272</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2338078202</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-ed5052fefa1a2fbd04731785e5562c37fd08083883fc78707a9c2f7b171f5fa3</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMoWqsv4EIG3LiJniRmkllKqRcQdCG4DGnmREemmZrMgH0pH8InM7VewIWrHPi_8-fwEXLA4IQBqNPEQFWcAgcKjOuS6g0yYlIJyksBm2QErJRUKmA7ZDelZwCoVFVukx3BKgFnohyRhwvr-i6mogm-HTC4JjwW_RMWEevB9U0XclK4Lga0bYGh7nLYNnl22LapsL7HWExf6V3ElN7fijTER4zLPbLlbZtw_-sdk_uL6f3kit7cXl5Pzm-oE0r2FGsJknv0llnuZzWcKcGUlihlyTPia9CghdbCO6UVKFs57tWMKealt2JMjte1i9i9DJh6M2_S6jIbsBuS4UJoUJoDz-jRH_S5G2LIx2WqKmWm1Iria8rFLqWI3ixiM7dxaRiYlXWztm6ydfNp3ei8dPhVPczmWP-sfGvOgFgDKUch-_n9-5_aD1jtjW8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2396578272</pqid></control><display><type>article</type><title>Factors influencing the reduction in corneal endothelial cells after Ex-Press® surgery</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tojo, Naoki ; Numata, Ayaka ; Hayashi, Atsushi</creator><creatorcontrib>Tojo, Naoki ; Numata, Ayaka ; Hayashi, Atsushi</creatorcontrib><description>Purpose
We investigated the factors that influence the reduction in corneal endothelial cells after Ex-Press
®
surgery.
Methods
This was a retrospective study. We included patients who had undergone Ex-Press surgery and were followed up for > 2. We analyzed the corneal endothelial cell density (ECD) before and after Ex-Press surgery. We investigated the insertion position (Ex-Press device was inserted into cornea or trabecular meshwork (TM)), Ex-Press–iris touch, cornea–iris touch, peripheral anterior synechiae, history of trabeculotomy, history of selective laser trabeculoplasty, type of glaucoma, and simultaneous cataract surgery as influencing factors. We used multivariate analysis to determine the factors influencing the reduction rate of ECD.
Results
We included 129 eyes. The mean of ECD had decreased 7.0% at 2 years. Ex-Press surgeries significantly decreased the ECD after 2 years (
p
= 0.0118). As a result of the multivariate analysis, the factor that led to a significantly faster reduction in ECD was the insertion position of the Ex-Press (
p
< 0.0001). The reduction rate of ECD after 2 years in cases of insertion into the cornea (27 eyes) was 15.1 ± 3.6%, and in cases of insertion into a TM (102 eyes), it was 5.2 ± 1.4%.
Conclusions
Insertion into the cornea was a risk factor for rapid ECD loss. The Ex-Press should be inserted into a TM for long-term protection of the corneal endothelial cells.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-020-01286-8</identifier><identifier>PMID: 31930436</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Cataracts ; Cell Count ; Cell density ; Cornea ; Corneal Endothelial Cell Loss - diagnosis ; Corneal Endothelial Cell Loss - etiology ; Corneal Endothelial Cell Loss - prevention & control ; Endothelial cells ; Endothelium, Corneal - pathology ; Eye ; Eye (anatomy) ; Glaucoma ; Glaucoma - physiopathology ; Glaucoma - surgery ; Glaucoma Drainage Implants - adverse effects ; Humans ; Insertion ; Intraocular Pressure - physiology ; Iris ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Ophthalmology ; Original Paper ; Retrospective Studies ; Risk analysis ; Risk Factors ; Surgery ; Touch ; Trabeculectomy - adverse effects</subject><ispartof>International ophthalmology, 2020-05, Vol.40 (5), p.1201-1208</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ed5052fefa1a2fbd04731785e5562c37fd08083883fc78707a9c2f7b171f5fa3</citedby><cites>FETCH-LOGICAL-c375t-ed5052fefa1a2fbd04731785e5562c37fd08083883fc78707a9c2f7b171f5fa3</cites><orcidid>0000-0002-8036-4781</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-020-01286-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-020-01286-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31930436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tojo, Naoki</creatorcontrib><creatorcontrib>Numata, Ayaka</creatorcontrib><creatorcontrib>Hayashi, Atsushi</creatorcontrib><title>Factors influencing the reduction in corneal endothelial cells after Ex-Press® surgery</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
We investigated the factors that influence the reduction in corneal endothelial cells after Ex-Press
®
surgery.
Methods
This was a retrospective study. We included patients who had undergone Ex-Press surgery and were followed up for > 2. We analyzed the corneal endothelial cell density (ECD) before and after Ex-Press surgery. We investigated the insertion position (Ex-Press device was inserted into cornea or trabecular meshwork (TM)), Ex-Press–iris touch, cornea–iris touch, peripheral anterior synechiae, history of trabeculotomy, history of selective laser trabeculoplasty, type of glaucoma, and simultaneous cataract surgery as influencing factors. We used multivariate analysis to determine the factors influencing the reduction rate of ECD.
Results
We included 129 eyes. The mean of ECD had decreased 7.0% at 2 years. Ex-Press surgeries significantly decreased the ECD after 2 years (
p
= 0.0118). As a result of the multivariate analysis, the factor that led to a significantly faster reduction in ECD was the insertion position of the Ex-Press (
p
< 0.0001). The reduction rate of ECD after 2 years in cases of insertion into the cornea (27 eyes) was 15.1 ± 3.6%, and in cases of insertion into a TM (102 eyes), it was 5.2 ± 1.4%.
Conclusions
Insertion into the cornea was a risk factor for rapid ECD loss. The Ex-Press should be inserted into a TM for long-term protection of the corneal endothelial cells.</description><subject>Cataracts</subject><subject>Cell Count</subject><subject>Cell density</subject><subject>Cornea</subject><subject>Corneal Endothelial Cell Loss - diagnosis</subject><subject>Corneal Endothelial Cell Loss - etiology</subject><subject>Corneal Endothelial Cell Loss - prevention & control</subject><subject>Endothelial cells</subject><subject>Endothelium, Corneal - pathology</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Glaucoma</subject><subject>Glaucoma - physiopathology</subject><subject>Glaucoma - surgery</subject><subject>Glaucoma Drainage Implants - adverse effects</subject><subject>Humans</subject><subject>Insertion</subject><subject>Intraocular Pressure - physiology</subject><subject>Iris</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Touch</subject><subject>Trabeculectomy - adverse effects</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMtKAzEUhoMoWqsv4EIG3LiJniRmkllKqRcQdCG4DGnmREemmZrMgH0pH8InM7VewIWrHPi_8-fwEXLA4IQBqNPEQFWcAgcKjOuS6g0yYlIJyksBm2QErJRUKmA7ZDelZwCoVFVukx3BKgFnohyRhwvr-i6mogm-HTC4JjwW_RMWEevB9U0XclK4Lga0bYGh7nLYNnl22LapsL7HWExf6V3ElN7fijTER4zLPbLlbZtw_-sdk_uL6f3kit7cXl5Pzm-oE0r2FGsJknv0llnuZzWcKcGUlihlyTPia9CghdbCO6UVKFs57tWMKealt2JMjte1i9i9DJh6M2_S6jIbsBuS4UJoUJoDz-jRH_S5G2LIx2WqKmWm1Iria8rFLqWI3ixiM7dxaRiYlXWztm6ydfNp3ei8dPhVPczmWP-sfGvOgFgDKUch-_n9-5_aD1jtjW8</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Tojo, Naoki</creator><creator>Numata, Ayaka</creator><creator>Hayashi, Atsushi</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8036-4781</orcidid></search><sort><creationdate>20200501</creationdate><title>Factors influencing the reduction in corneal endothelial cells after Ex-Press® surgery</title><author>Tojo, Naoki ; Numata, Ayaka ; Hayashi, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ed5052fefa1a2fbd04731785e5562c37fd08083883fc78707a9c2f7b171f5fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cataracts</topic><topic>Cell Count</topic><topic>Cell density</topic><topic>Cornea</topic><topic>Corneal Endothelial Cell Loss - diagnosis</topic><topic>Corneal Endothelial Cell Loss - etiology</topic><topic>Corneal Endothelial Cell Loss - prevention & control</topic><topic>Endothelial cells</topic><topic>Endothelium, Corneal - pathology</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Glaucoma</topic><topic>Glaucoma - physiopathology</topic><topic>Glaucoma - surgery</topic><topic>Glaucoma Drainage Implants - adverse effects</topic><topic>Humans</topic><topic>Insertion</topic><topic>Intraocular Pressure - physiology</topic><topic>Iris</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Touch</topic><topic>Trabeculectomy - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tojo, Naoki</creatorcontrib><creatorcontrib>Numata, Ayaka</creatorcontrib><creatorcontrib>Hayashi, Atsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tojo, Naoki</au><au>Numata, Ayaka</au><au>Hayashi, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors influencing the reduction in corneal endothelial cells after Ex-Press® surgery</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>40</volume><issue>5</issue><spage>1201</spage><epage>1208</epage><pages>1201-1208</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
We investigated the factors that influence the reduction in corneal endothelial cells after Ex-Press
®
surgery.
Methods
This was a retrospective study. We included patients who had undergone Ex-Press surgery and were followed up for > 2. We analyzed the corneal endothelial cell density (ECD) before and after Ex-Press surgery. We investigated the insertion position (Ex-Press device was inserted into cornea or trabecular meshwork (TM)), Ex-Press–iris touch, cornea–iris touch, peripheral anterior synechiae, history of trabeculotomy, history of selective laser trabeculoplasty, type of glaucoma, and simultaneous cataract surgery as influencing factors. We used multivariate analysis to determine the factors influencing the reduction rate of ECD.
Results
We included 129 eyes. The mean of ECD had decreased 7.0% at 2 years. Ex-Press surgeries significantly decreased the ECD after 2 years (
p
= 0.0118). As a result of the multivariate analysis, the factor that led to a significantly faster reduction in ECD was the insertion position of the Ex-Press (
p
< 0.0001). The reduction rate of ECD after 2 years in cases of insertion into the cornea (27 eyes) was 15.1 ± 3.6%, and in cases of insertion into a TM (102 eyes), it was 5.2 ± 1.4%.
Conclusions
Insertion into the cornea was a risk factor for rapid ECD loss. The Ex-Press should be inserted into a TM for long-term protection of the corneal endothelial cells.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31930436</pmid><doi>10.1007/s10792-020-01286-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8036-4781</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5701 |
| ispartof | International ophthalmology, 2020-05, Vol.40 (5), p.1201-1208 |
| issn | 0165-5701 1573-2630 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Cataracts Cell Count Cell density Cornea Corneal Endothelial Cell Loss - diagnosis Corneal Endothelial Cell Loss - etiology Corneal Endothelial Cell Loss - prevention & control Endothelial cells Endothelium, Corneal - pathology Eye Eye (anatomy) Glaucoma Glaucoma - physiopathology Glaucoma - surgery Glaucoma Drainage Implants - adverse effects Humans Insertion Intraocular Pressure - physiology Iris Medicine Medicine & Public Health Multivariate analysis Ophthalmology Original Paper Retrospective Studies Risk analysis Risk Factors Surgery Touch Trabeculectomy - adverse effects |
| title | Factors influencing the reduction in corneal endothelial cells after Ex-Press® surgery |
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