The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

Cancer cells increase lipogenesis for their proliferation and the activation of sterol regulatory element-binding proteins (SREBPs) has a central role in this process. SREBPs are inhibited by a complex composed of INSIG proteins, SREBP cleavage-activating protein (SCAP) and sterols in the endoplasmi...

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Veröffentlicht in:	Nature (London) 2020-04, Vol.580 (7804), p.530-535
Hauptverfasser:	Xu, Daqian, Wang, Zheng, Xia, Yan, Shao, Fei, Xia, Weiya, Wei, Yongkun, Li, Xinjian, Qian, Xu, Lee, Jong-Ho, Du, Linyong, Zheng, Yanhua, Lv, Guishuai, Leu, Jia-shiun, Wang, Hongyang, Xing, Dongming, Liang, Tingbo, Hung, Mien-Chie, Lu, Zhimin
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 14/63 42/109 42/70 42/89 631/45/607/275 631/80/86/2368 82/29 82/51 82/83 Activation AKT protein Analysis Animals Binding Cancer Carcinogenesis Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Proliferation Disease Models, Animal Dissociation Endoplasmic reticulum Endoplasmic Reticulum - metabolism Enzymes Fat metabolism Gluconeogenesis Golgi apparatus Golgi Apparatus - metabolism Guanosine triphosphate Hepatocellular carcinoma Humanities and Social Sciences Humans Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - metabolism Kinases Lipogenesis Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Membrane proteins Membrane Proteins - chemistry Membrane Proteins - metabolism Methods Mice Mice, Nude multidisciplinary Oxysterols - metabolism Peptides Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate Carboxykinase (GTP) - metabolism Phosphorylation Prognosis Protein Binding Protein kinase Protein Transport Proteins Proto-Oncogene Proteins c-akt - metabolism Regulatory sequences Science Science (multidisciplinary) Sterol Regulatory Element Binding Protein 1 - metabolism Sterol Regulatory Element Binding Protein 2 - metabolism Sterol regulatory element-binding protein Sterols Transcription Translocation Tumorigenesis Tumors
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