Hypofractioned radiotherapy versus conventional radiotherapy for the treatment of multiform glioblastoma in adults over 70 years old
Aim:Multiform glioblastoma (MG) represents 70% of all gliomas, with half of patients older than 65 years with median survival of 12–18 months, hypofractionation seeks to reduce the intensity and duration of treatment without impacting on survival rates. The objective was to determine the global surv...
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| Veröffentlicht in: | Journal of radiotherapy in practice 2020-06, Vol.19 (2), p.193-196 |
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| container_title | Journal of radiotherapy in practice |
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| creator | Jiménez Cantero, Adriana Chávez Nogueda, Jessica Flores Vázquez, Fabiola Castillo de la Garza, José Pablo Hernández Montes de Oca, Raymundo Olmos Guzmán, Alejandro |
| description | Aim:Multiform glioblastoma (MG) represents 70% of all gliomas, with half of patients older than 65 years with median survival of 12–18 months, hypofractionation seeks to reduce the intensity and duration of treatment without impacting on survival rates. The objective was to determine the global survival and recurrence-free survival of adults over 70 years old with MG treated with hypofractionated radiotherapy and standard scheme. The review of patients older than 70 years treated with radiotherapy from 2013 to 2016 was performed.Results:Twenty-four patients were analysed, with a median follow-up of 239 days, and there is no difference in overall survival 12·3 versus 10·5 months (p = 0·55) and recurrence-free survival 8·3 versus 3·4 months (p = 0·48) between both schemes, conventional versus hypofractioanted, respectively.Conclusion:The results in this study show that hypofractionated scheme could be comparable in overall survival and recurrence-free survival to conventional fractionation, but a longer patients’ trial should be done. |
| doi_str_mv | 10.1017/S146039691900044X |
| format | Article |
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The objective was to determine the global survival and recurrence-free survival of adults over 70 years old with MG treated with hypofractionated radiotherapy and standard scheme. The review of patients older than 70 years treated with radiotherapy from 2013 to 2016 was performed.Results:Twenty-four patients were analysed, with a median follow-up of 239 days, and there is no difference in overall survival 12·3 versus 10·5 months (p = 0·55) and recurrence-free survival 8·3 versus 3·4 months (p = 0·48) between both schemes, conventional versus hypofractioanted, respectively.Conclusion:The results in this study show that hypofractionated scheme could be comparable in overall survival and recurrence-free survival to conventional fractionation, but a longer patients’ trial should be done.</description><identifier>ISSN: 1460-3969</identifier><identifier>EISSN: 1467-1131</identifier><identifier>DOI: 10.1017/S146039691900044X</identifier><language>eng</language><publisher>Cambridge: Cambridge University Press</publisher><subject>Adults ; Age ; Biopsy ; Brain cancer ; Fractionation ; Fractions ; Glioblastoma ; Glioma ; Medical prognosis ; Older people ; Population ; Quality of life ; Radiation therapy ; Studies ; Survival ; Survival analysis</subject><ispartof>Journal of radiotherapy in practice, 2020-06, Vol.19 (2), p.193-196</ispartof><rights>Cambridge University Press 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c225t-ef1c1c257111b67566f08a22ff854b4f9dbf4828db84effd98d0e68a9766824d3</cites><orcidid>0000-0002-8237-4166</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Jiménez Cantero, Adriana</creatorcontrib><creatorcontrib>Chávez Nogueda, Jessica</creatorcontrib><creatorcontrib>Flores Vázquez, Fabiola</creatorcontrib><creatorcontrib>Castillo de la Garza, José Pablo</creatorcontrib><creatorcontrib>Hernández Montes de Oca, Raymundo</creatorcontrib><creatorcontrib>Olmos Guzmán, Alejandro</creatorcontrib><title>Hypofractioned radiotherapy versus conventional radiotherapy for the treatment of multiform glioblastoma in adults over 70 years old</title><title>Journal of radiotherapy in practice</title><description>Aim:Multiform glioblastoma (MG) represents 70% of all gliomas, with half of patients older than 65 years with median survival of 12–18 months, hypofractionation seeks to reduce the intensity and duration of treatment without impacting on survival rates. 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| ispartof | Journal of radiotherapy in practice, 2020-06, Vol.19 (2), p.193-196 |
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| source | Cambridge Journals |
| subjects | Adults Age Biopsy Brain cancer Fractionation Fractions Glioblastoma Glioma Medical prognosis Older people Population Quality of life Radiation therapy Studies Survival Survival analysis |
| title | Hypofractioned radiotherapy versus conventional radiotherapy for the treatment of multiform glioblastoma in adults over 70 years old |
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