DNA Encoded Libraries: A Visitor's Guide

In 1992, Brenner and Lerner hypothesized that individual chemical transformations could be encoded in DNA, allowing the rapid synthesis and screening of large collections of small molecules. Since their report, huge investments into the development of the DNA encoded library (DEL) technology have en...

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Veröffentlicht in:	Israel journal of chemistry 2020-03, Vol.60 (3-4), p.268-280
Hauptverfasser:	Flood, Dillon T., Kingston, Cian, Vantourout, Julien C., Dawson, Philip E., Baran, Phil S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acceleration Binding Biology Chemistry Deoxyribonucleic acid DNA Drug discovery Encoded Guide HTS Libraries Target recognition Transformations
Online-Zugang:	Volltext
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