Effect of Derivatives of Hydroxamic Acids on Vasculogenic Mimicry
— Vasculogenic mimicry, the formation of vascular channels lined with tumor cells of a highly malignant phenotype, is currently considered as an additional system of blood supply of the tumor. Experimental studies in vivo have repeatedly demonstrated that vascular channels form in the areas of a tum...
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| Veröffentlicht in: | Russian journal of bioorganic chemistry 2020-03, Vol.46 (2), p.252-263 |
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| container_title | Russian journal of bioorganic chemistry |
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| creator | Vartanian, A. A. Khochenkov, D. A. Khochenkova, Yu. A. Machkova, Yu. S. Khachatryan, D. S. Kolotaev, A. V. Balaev, A. N. Ohmanovich, K. A. Osipov, V. N. |
| description | —
Vasculogenic mimicry, the formation of vascular channels lined with tumor cells of a highly malignant phenotype, is currently considered as an additional system of blood supply of the tumor. Experimental studies in vivo have repeatedly demonstrated that vascular channels form in the areas of a tumor with a low density of blood vessels. It is supposed that the formation of a network of these channels inside the tumor maintains homeostasis and prevents early necrosis within it. In this work, bifunctional compounds based on a combination of quinazoline and hydroxamic acid in one molecule were examined for the ability to inhibit the migration of tumor cells and vasculogenic mimicry. |
| doi_str_mv | 10.1134/S106816202002017X |
| format | Article |
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Vasculogenic mimicry, the formation of vascular channels lined with tumor cells of a highly malignant phenotype, is currently considered as an additional system of blood supply of the tumor. Experimental studies in vivo have repeatedly demonstrated that vascular channels form in the areas of a tumor with a low density of blood vessels. It is supposed that the formation of a network of these channels inside the tumor maintains homeostasis and prevents early necrosis within it. In this work, bifunctional compounds based on a combination of quinazoline and hydroxamic acid in one molecule were examined for the ability to inhibit the migration of tumor cells and vasculogenic mimicry.</description><identifier>ISSN: 1068-1620</identifier><identifier>EISSN: 1608-330X</identifier><identifier>DOI: 10.1134/S106816202002017X</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Blood vessels ; Channels ; Homeostasis ; In vivo methods and tests ; Life Sciences ; Mimicry ; Necrosis ; Organic Chemistry ; Tumors</subject><ispartof>Russian journal of bioorganic chemistry, 2020-03, Vol.46 (2), p.252-263</ispartof><rights>Pleiades Publishing, Ltd. 2020</rights><rights>Pleiades Publishing, Ltd. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-e1c1c64be03f60d847ec3af7e79625b3700f86fb7629774e394031bbc08428ff3</citedby><cites>FETCH-LOGICAL-c316t-e1c1c64be03f60d847ec3af7e79625b3700f86fb7629774e394031bbc08428ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S106816202002017X$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S106816202002017X$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids></links><search><creatorcontrib>Vartanian, A. A.</creatorcontrib><creatorcontrib>Khochenkov, D. A.</creatorcontrib><creatorcontrib>Khochenkova, Yu. A.</creatorcontrib><creatorcontrib>Machkova, Yu. S.</creatorcontrib><creatorcontrib>Khachatryan, D. S.</creatorcontrib><creatorcontrib>Kolotaev, A. V.</creatorcontrib><creatorcontrib>Balaev, A. N.</creatorcontrib><creatorcontrib>Ohmanovich, K. A.</creatorcontrib><creatorcontrib>Osipov, V. N.</creatorcontrib><title>Effect of Derivatives of Hydroxamic Acids on Vasculogenic Mimicry</title><title>Russian journal of bioorganic chemistry</title><addtitle>Russ J Bioorg Chem</addtitle><description>—
Vasculogenic mimicry, the formation of vascular channels lined with tumor cells of a highly malignant phenotype, is currently considered as an additional system of blood supply of the tumor. Experimental studies in vivo have repeatedly demonstrated that vascular channels form in the areas of a tumor with a low density of blood vessels. It is supposed that the formation of a network of these channels inside the tumor maintains homeostasis and prevents early necrosis within it. In this work, bifunctional compounds based on a combination of quinazoline and hydroxamic acid in one molecule were examined for the ability to inhibit the migration of tumor cells and vasculogenic mimicry.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Blood vessels</subject><subject>Channels</subject><subject>Homeostasis</subject><subject>In vivo methods and tests</subject><subject>Life Sciences</subject><subject>Mimicry</subject><subject>Necrosis</subject><subject>Organic Chemistry</subject><subject>Tumors</subject><issn>1068-1620</issn><issn>1608-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1UN1LwzAQD6LgnP4BvhV8rt4laZI-jjmdMPHBD_ZW2uwyOrZ2Jt1w_70pE3wQ4eDufl8Hx9g1wi2ikHevCMqg4sAhFur5CRugApMKAfPTOEc67flzdhHCCgABMjNgo4lzZLukdck9-XpfdvWeQr9ODwvffpWb2iYjWy8i1iQfZbC7dbukJqLPdeT84ZKduXId6OqnD9n7w-RtPE1nL49P49EstQJVlxJatEpWBMIpWBipyYrSadK54lklNIAzylVa8VxrSSKXILCqLBjJjXNiyG6OuVvffu4odMWq3fkmniy4yDOBKI2JKjyqrG9D8OSKra83pT8UCEX_qeLPp6KHHz0hapsl-d_k_03fiJ9pDQ</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Vartanian, A. A.</creator><creator>Khochenkov, D. A.</creator><creator>Khochenkova, Yu. A.</creator><creator>Machkova, Yu. S.</creator><creator>Khachatryan, D. S.</creator><creator>Kolotaev, A. V.</creator><creator>Balaev, A. N.</creator><creator>Ohmanovich, K. A.</creator><creator>Osipov, V. N.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200301</creationdate><title>Effect of Derivatives of Hydroxamic Acids on Vasculogenic Mimicry</title><author>Vartanian, A. A. ; Khochenkov, D. A. ; Khochenkova, Yu. A. ; Machkova, Yu. S. ; Khachatryan, D. S. ; Kolotaev, A. V. ; Balaev, A. N. ; Ohmanovich, K. A. ; Osipov, V. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-e1c1c64be03f60d847ec3af7e79625b3700f86fb7629774e394031bbc08428ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Blood vessels</topic><topic>Channels</topic><topic>Homeostasis</topic><topic>In vivo methods and tests</topic><topic>Life Sciences</topic><topic>Mimicry</topic><topic>Necrosis</topic><topic>Organic Chemistry</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vartanian, A. A.</creatorcontrib><creatorcontrib>Khochenkov, D. A.</creatorcontrib><creatorcontrib>Khochenkova, Yu. A.</creatorcontrib><creatorcontrib>Machkova, Yu. S.</creatorcontrib><creatorcontrib>Khachatryan, D. S.</creatorcontrib><creatorcontrib>Kolotaev, A. V.</creatorcontrib><creatorcontrib>Balaev, A. N.</creatorcontrib><creatorcontrib>Ohmanovich, K. A.</creatorcontrib><creatorcontrib>Osipov, V. N.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of bioorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vartanian, A. A.</au><au>Khochenkov, D. A.</au><au>Khochenkova, Yu. A.</au><au>Machkova, Yu. S.</au><au>Khachatryan, D. S.</au><au>Kolotaev, A. V.</au><au>Balaev, A. N.</au><au>Ohmanovich, K. A.</au><au>Osipov, V. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Derivatives of Hydroxamic Acids on Vasculogenic Mimicry</atitle><jtitle>Russian journal of bioorganic chemistry</jtitle><stitle>Russ J Bioorg Chem</stitle><date>2020-03-01</date><risdate>2020</risdate><volume>46</volume><issue>2</issue><spage>252</spage><epage>263</epage><pages>252-263</pages><issn>1068-1620</issn><eissn>1608-330X</eissn><abstract>—
Vasculogenic mimicry, the formation of vascular channels lined with tumor cells of a highly malignant phenotype, is currently considered as an additional system of blood supply of the tumor. Experimental studies in vivo have repeatedly demonstrated that vascular channels form in the areas of a tumor with a low density of blood vessels. It is supposed that the formation of a network of these channels inside the tumor maintains homeostasis and prevents early necrosis within it. In this work, bifunctional compounds based on a combination of quinazoline and hydroxamic acid in one molecule were examined for the ability to inhibit the migration of tumor cells and vasculogenic mimicry.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S106816202002017X</doi><tpages>12</tpages></addata></record> |
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| ispartof | Russian journal of bioorganic chemistry, 2020-03, Vol.46 (2), p.252-263 |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Blood vessels Channels Homeostasis In vivo methods and tests Life Sciences Mimicry Necrosis Organic Chemistry Tumors |
| title | Effect of Derivatives of Hydroxamic Acids on Vasculogenic Mimicry |
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