Translesion DNA Synthesis and Carcinogenesis

Tens of thousands of DNA lesions are formed in mammalian cells each day. DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol ι), eta (Pol η), kappa (Pol κ), and zeta (Pol ζ) have active sites that are less stringent toward the DNA...

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Veröffentlicht in:	Biochemistry (Moscow) 2020-04, Vol.85 (4), p.425-435
Hauptverfasser:	Shilkin, E. S., Boldinova, E. O., Stolyarenko, A. D., Goncharova, R. I., Chuprov-Netochin, R. N., Khairullin, R. F., Smal, M. P., Makarova, A. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Carcinogenesis Carcinogens Deoxyribonucleic acid DNA DNA biosynthesis DNA Damage DNA Repair DNA Replication DNA structure DNA synthesis DNA-directed DNA polymerase DNA-Directed DNA Polymerase - metabolism Genetic aspects Health risks Humans Lesions Life Sciences Mammalian cells Methods Microbiology Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Nucleotides Review
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