In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines
According to the in silico consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative in vitro evaluation of the effect of the synthesized compo...
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| Veröffentlicht in: | Russian chemical bulletin 2020-04, Vol.69 (4), p.768-773 |
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| creator | Ishmetova, R. I. Babkov, D. A. Kucheryavenko, A. F. Babkova, V. A. Sirotenko, V. S. Ignatenko, N. K. Tolschina, S. G. Vassiliev, P. M. Rusinov, G. L. Spasov, A. A. |
| description | According to the
in silico
consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative
in vitro
evaluation of the effect of the synthesized compounds on the ADP-induced rabbit platelet aggregation model was carried out. Compounds with antiglycation and antiplatelet activities significantly higher than that of the reference drugs, aminoguanidine and acetylsalicylic acid, were revealed. |
| doi_str_mv | 10.1007/s11172-020-2831-6 |
| format | Article |
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in silico
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in vitro
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in silico
consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative
in vitro
evaluation of the effect of the synthesized compounds on the ADP-induced rabbit platelet aggregation model was carried out. Compounds with antiglycation and antiplatelet activities significantly higher than that of the reference drugs, aminoguanidine and acetylsalicylic acid, were revealed.</description><subject>Acetylsalicylic acid</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Full Articles</subject><subject>Inorganic Chemistry</subject><subject>Maillard reaction</subject><subject>Organic Chemistry</subject><issn>1066-5285</issn><issn>1573-9171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1Uctq3EAQFCGG-PUBvg3kqkmmRzsPHY2xE8NCLvZ5GEmt9SyytJkeLWy-Jp_qkZWQU07dXV1VUFRR3ID4AkKYrwQARnIhBZe2Aq4_FOegTMVrMPAx70JrrqRVn4oLor0QQlprz4vfjyOjMIR2Yu00Eo40E_NtCseQTuwQsQv5mMaSRb9MPzA6jekFKVDJ_NgxPPphfv-xqc9ICrvh1K7A8l-Qw-ATDpj-OgekhVyVmneB5oZSSHPCjkEpy02peMIU_a8wIl0VZ70fCK__zMvi-eH-6e473_749nh3u-VtBTpxY4yFthJNnzNuOlRSNabRBo00RkBte9k3smsA0FfKG61Ayl5g3VrbNaqrLovPq-8hTj9npOT20xxzXnKyqje11MaozIKV1caJKGLvDjG8-nhyINxShFuLcLkItxThdNbIVUOZO-4w_nP-v-gNi2mNrg</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Ishmetova, R. I.</creator><creator>Babkov, D. A.</creator><creator>Kucheryavenko, A. F.</creator><creator>Babkova, V. A.</creator><creator>Sirotenko, V. S.</creator><creator>Ignatenko, N. K.</creator><creator>Tolschina, S. G.</creator><creator>Vassiliev, P. M.</creator><creator>Rusinov, G. L.</creator><creator>Spasov, A. A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200401</creationdate><title>In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines</title><author>Ishmetova, R. I. ; Babkov, D. A. ; Kucheryavenko, A. F. ; Babkova, V. A. ; Sirotenko, V. S. ; Ignatenko, N. K. ; Tolschina, S. G. ; Vassiliev, P. M. ; Rusinov, G. L. ; Spasov, A. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-77781c30bf2854de525b7b67e72770198f2fb2db11ea35a765122f0e9c88db5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetylsalicylic acid</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Full Articles</topic><topic>Inorganic Chemistry</topic><topic>Maillard reaction</topic><topic>Organic Chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishmetova, R. I.</creatorcontrib><creatorcontrib>Babkov, D. A.</creatorcontrib><creatorcontrib>Kucheryavenko, A. F.</creatorcontrib><creatorcontrib>Babkova, V. A.</creatorcontrib><creatorcontrib>Sirotenko, V. S.</creatorcontrib><creatorcontrib>Ignatenko, N. K.</creatorcontrib><creatorcontrib>Tolschina, S. G.</creatorcontrib><creatorcontrib>Vassiliev, P. M.</creatorcontrib><creatorcontrib>Rusinov, G. L.</creatorcontrib><creatorcontrib>Spasov, A. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian chemical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishmetova, R. I.</au><au>Babkov, D. A.</au><au>Kucheryavenko, A. F.</au><au>Babkova, V. A.</au><au>Sirotenko, V. S.</au><au>Ignatenko, N. K.</au><au>Tolschina, S. G.</au><au>Vassiliev, P. M.</au><au>Rusinov, G. L.</au><au>Spasov, A. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines</atitle><jtitle>Russian chemical bulletin</jtitle><stitle>Russ Chem Bull</stitle><date>2020-04-01</date><risdate>2020</risdate><volume>69</volume><issue>4</issue><spage>768</spage><epage>773</epage><pages>768-773</pages><issn>1066-5285</issn><eissn>1573-9171</eissn><abstract>According to the
in silico
consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative
in vitro
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| subjects | Acetylsalicylic acid Chemistry Chemistry and Materials Science Chemistry/Food Science Full Articles Inorganic Chemistry Maillard reaction Organic Chemistry |
| title | In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines |
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