Enhancement of aberrantly modified integrin‑mediated cell motility in multicellular tumor spheroids

Multicellular tumor spheroids (MTSs) of malignant cells can display cell‑cell and cell‑matrix interactions, different from monolayer cultures. The objective of the present study was to examine difference in intercellular and cell‑matrix interaction between monolayered cultures and spheroid cultures....

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Veröffentlicht in:	International journal of oncology 2020-06, Vol.56 (6), p.1490-1488
Hauptverfasser:	Kim, Byoungjae, Im, Nu-Ri, Yang, Taeseok Daniel, Kim, Jian, Jung, Kwang-Yoon, Kim, Tae Hoon, Baek, Seung-Kuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing - pharmacology Antigens, CD - metabolism Binding sites Biotechnology Cadherins - metabolism Cancer Cancer metastasis Cancer therapies Carcinoma Cell adhesion & migration Cell Culture Techniques - methods Cell Line, Tumor Cell Movement - drug effects Comparative analysis Displays (Marketing) Down-Regulation Epithelial-Mesenchymal Transition - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Integrin beta1 - metabolism Integrins Kinases Laboratories Metastasis Motility Signal Transduction - drug effects Single-Cell Analysis Software Spheroids Spheroids, Cellular - cytology Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Stem cells Thermal cycling Thyroid cancer Thyroid diseases Tumors Up-Regulation - drug effects
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