In Vitro and In Vivo Assessment of Designed Melphalan Loaded Stealth Solid Lipid Nanoparticles for Parenteral Delivery

The aim of the present study is to develop the melphalan (MLN) loaded stealth solid lipid nanoparticles (SSLNs) for parenteral delivery by hot homogenization technique using central composite design. Amount of tristearin, soyalecithin, and DSPE-m-PEG-2000 is taken as independent factor whereas the p...

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Veröffentlicht in:	BioNanoScience 2020-03, Vol.10 (1), p.168-190
Hauptverfasser:	Rudhrabatla, V. S. A. Pavan, Sudhakar, Beeravelli, Reddy, K. V. N. Suresh
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Biological and Medical Physics Biomaterials Biophysics Cell viability Circuits and Systems Design Dialysis Drug delivery systems Efficiency Encapsulation Engineering Homogenization In vivo methods and tests Lipids Melphalan Nanoparticles Nanotechnology Parameters Particle size pH effects Pharmacokinetics Pharmacology Polydispersity Stability Stearin Sterilization Tristearin Zeta potential
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