A Double-Blind Comparison of the Effects of Temazepam and Triazolam on Residual, Daytime Performance in Elderly Insomniacs
Benzodiazepine hypnotic medications are widely prescribed for elderly patients, but there is a paucity of information available concerning the resudual cognitive and psychomotor (the morning-after) effects of these drugs. We compared two commonly used hypnotics—temazepam and triazolam—in a double-bl...
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| Veröffentlicht in: | International psychogeriatrics 1992-06, Vol.4 (1), p.45-53 |
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| creator | Nakra, Bharat Raj S. Gfeller, Jeffrey D. Hassan, Rakhshanda |
| description | Benzodiazepine hypnotic medications are widely prescribed for elderly patients, but there is a paucity of information available concerning the resudual cognitive and psychomotor (the morning-after) effects of these drugs. We compared two commonly used hypnotics—temazepam and triazolam—in a double-blind, placebo-controlled, single-dose study with community-dwelling healthy elderly with a DSM-III-R diagnosis of primary insomnia. Fortyfive subjects over the age of 65 (mean age 72.23, SD = 4.44) qualified for the study. Subjects were randomly assigned to one of five treatment groups (placebo, triazolam 0.125 mg., triazolam 0.25 mg., temazepam 15 mg., and temazepam 30 mg.). Neuropsychological testing was completed at baseline and 12–14 hours after the dosing. Patients were evaluated with a variety of tests that measured attention, concentration, motor speed, immediate memory, and learning of new information. Separate repeated measured analyses of variance were performed to assess the significant changes among the five treatment groups. We found improved performance or no change in all the measures for all medication groups except for impairment of performance on a serial learning task for both high-dose medication groups. The significance of these results and the need for further research in elderly insomniacs is discussed. |
| doi_str_mv | 10.1017/S1041610292000899 |
| format | Article |
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We compared two commonly used hypnotics—temazepam and triazolam—in a double-blind, placebo-controlled, single-dose study with community-dwelling healthy elderly with a DSM-III-R diagnosis of primary insomnia. Fortyfive subjects over the age of 65 (mean age 72.23, SD = 4.44) qualified for the study. Subjects were randomly assigned to one of five treatment groups (placebo, triazolam 0.125 mg., triazolam 0.25 mg., temazepam 15 mg., and temazepam 30 mg.). Neuropsychological testing was completed at baseline and 12–14 hours after the dosing. Patients were evaluated with a variety of tests that measured attention, concentration, motor speed, immediate memory, and learning of new information. Separate repeated measured analyses of variance were performed to assess the significant changes among the five treatment groups. We found improved performance or no change in all the measures for all medication groups except for impairment of performance on a serial learning task for both high-dose medication groups. The significance of these results and the need for further research in elderly insomniacs is discussed.</description><identifier>ISSN: 1041-6102</identifier><identifier>EISSN: 1741-203X</identifier><identifier>DOI: 10.1017/S1041610292000899</identifier><identifier>PMID: 1391671</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Aged ; Cognition - drug effects ; Double-Blind Method ; Double-blind studies ; Female ; Geriatric Assessment ; Humans ; Insomnia ; Male ; Neuropsychological Tests ; Older people ; Psychomotor Performance - drug effects ; Research and Reviews ; Sleep Initiation and Maintenance Disorders - diagnosis ; Sleep Initiation and Maintenance Disorders - drug therapy ; Temazepam - administration & dosage ; Temazepam - adverse effects ; Temazepam - therapeutic use ; Triazolam - administration & dosage ; Triazolam - adverse effects ; Triazolam - therapeutic use</subject><ispartof>International psychogeriatrics, 1992-06, Vol.4 (1), p.45-53</ispartof><rights>1992 Springer Publishing Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c283t-9d9e34ccff2d0af14a5619e794cfcd676130dafc0e27c358d31d8a3789a5fcca3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1041610292000899/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,781,785,12851,27929,27930,31004,55633</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1391671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakra, Bharat Raj S.</creatorcontrib><creatorcontrib>Gfeller, Jeffrey D.</creatorcontrib><creatorcontrib>Hassan, Rakhshanda</creatorcontrib><title>A Double-Blind Comparison of the Effects of Temazepam and Triazolam on Residual, Daytime Performance in Elderly Insomniacs</title><title>International psychogeriatrics</title><addtitle>Int. Psychogeriatr</addtitle><description>Benzodiazepine hypnotic medications are widely prescribed for elderly patients, but there is a paucity of information available concerning the resudual cognitive and psychomotor (the morning-after) effects of these drugs. We compared two commonly used hypnotics—temazepam and triazolam—in a double-blind, placebo-controlled, single-dose study with community-dwelling healthy elderly with a DSM-III-R diagnosis of primary insomnia. Fortyfive subjects over the age of 65 (mean age 72.23, SD = 4.44) qualified for the study. Subjects were randomly assigned to one of five treatment groups (placebo, triazolam 0.125 mg., triazolam 0.25 mg., temazepam 15 mg., and temazepam 30 mg.). Neuropsychological testing was completed at baseline and 12–14 hours after the dosing. Patients were evaluated with a variety of tests that measured attention, concentration, motor speed, immediate memory, and learning of new information. Separate repeated measured analyses of variance were performed to assess the significant changes among the five treatment groups. We found improved performance or no change in all the measures for all medication groups except for impairment of performance on a serial learning task for both high-dose medication groups. The significance of these results and the need for further research in elderly insomniacs is discussed.</description><subject>Aged</subject><subject>Cognition - drug effects</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Humans</subject><subject>Insomnia</subject><subject>Male</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>Psychomotor Performance - drug effects</subject><subject>Research and Reviews</subject><subject>Sleep Initiation and Maintenance Disorders - diagnosis</subject><subject>Sleep Initiation and Maintenance Disorders - drug therapy</subject><subject>Temazepam - administration & dosage</subject><subject>Temazepam - adverse effects</subject><subject>Temazepam - therapeutic use</subject><subject>Triazolam - administration & dosage</subject><subject>Triazolam - adverse effects</subject><subject>Triazolam - therapeutic use</subject><issn>1041-6102</issn><issn>1741-203X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1UM9rFDEUDqLU2voHeBACXjual8zOTI51u2qhoOgWvA1vkxdNmUzWZOaw-9ebZRd6KD299_H9go-xdyA-goD20y8QNTQgpJZCiE7rF-wc2hoqKdTvl-UvdHXgX7M3OT8IIRcK6jN2BkpD08I521_zmzhvBqo-D360fBnDFpPPceTR8ekv8ZVzZKZ8gGsKuKctBo5Fuk4e93EoqIh_UvZ2xuGK3-Bu8oH4D0oupoCjIe5HvhospWHHb8ccw-jR5Ev2yuGQ6e3pXrD7L6v18lt19_3r7fL6rjKyU1OlrSZVG-OctAId1LhoQFOra-OMbdoGlLDojCDZGrXorALboWo7jQtnDKoL9uGYu03x30x56h_inMZS2Uulpe6kqHVRwVFlUsw5keu3yQdMux5Efxi7fzJ28bw_Jc-bQPbRcVy38OqUiWGTvP1Dj9XPp_4H4zeJvQ</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>Nakra, Bharat Raj S.</creator><creator>Gfeller, Jeffrey D.</creator><creator>Hassan, Rakhshanda</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19920601</creationdate><title>A Double-Blind Comparison of the Effects of Temazepam and Triazolam on Residual, Daytime Performance in Elderly Insomniacs</title><author>Nakra, Bharat Raj S. ; 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Psychogeriatr</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>4</volume><issue>1</issue><spage>45</spage><epage>53</epage><pages>45-53</pages><issn>1041-6102</issn><eissn>1741-203X</eissn><abstract>Benzodiazepine hypnotic medications are widely prescribed for elderly patients, but there is a paucity of information available concerning the resudual cognitive and psychomotor (the morning-after) effects of these drugs. We compared two commonly used hypnotics—temazepam and triazolam—in a double-blind, placebo-controlled, single-dose study with community-dwelling healthy elderly with a DSM-III-R diagnosis of primary insomnia. Fortyfive subjects over the age of 65 (mean age 72.23, SD = 4.44) qualified for the study. Subjects were randomly assigned to one of five treatment groups (placebo, triazolam 0.125 mg., triazolam 0.25 mg., temazepam 15 mg., and temazepam 30 mg.). Neuropsychological testing was completed at baseline and 12–14 hours after the dosing. Patients were evaluated with a variety of tests that measured attention, concentration, motor speed, immediate memory, and learning of new information. Separate repeated measured analyses of variance were performed to assess the significant changes among the five treatment groups. We found improved performance or no change in all the measures for all medication groups except for impairment of performance on a serial learning task for both high-dose medication groups. The significance of these results and the need for further research in elderly insomniacs is discussed.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>1391671</pmid><doi>10.1017/S1041610292000899</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1041-6102 |
| ispartof | International psychogeriatrics, 1992-06, Vol.4 (1), p.45-53 |
| issn | 1041-6102 1741-203X |
| language | eng |
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| source | MEDLINE; Cambridge Journals; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Aged Cognition - drug effects Double-Blind Method Double-blind studies Female Geriatric Assessment Humans Insomnia Male Neuropsychological Tests Older people Psychomotor Performance - drug effects Research and Reviews Sleep Initiation and Maintenance Disorders - diagnosis Sleep Initiation and Maintenance Disorders - drug therapy Temazepam - administration & dosage Temazepam - adverse effects Temazepam - therapeutic use Triazolam - administration & dosage Triazolam - adverse effects Triazolam - therapeutic use |
| title | A Double-Blind Comparison of the Effects of Temazepam and Triazolam on Residual, Daytime Performance in Elderly Insomniacs |
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