Managing Trade-offs in Protein Manufacturing: How Much to Waste?

We consider the challenges and trade-offs involved in the manufacturing of engineered proteins. Manufacturing these proteins involves high risk of financial losses due to the purity and yield trade-offs, uncertainty in the process outcomes, and high operating costs. In this setting, the biomanufactu...

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Veröffentlicht in:	Manufacturing & service operations management 2020-03, Vol.22 (2), p.330-345
Hauptverfasser:	Martagan, Tugce, Krishnamurthy, Ananth, Leland, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography Cost control Decision making models Manufacturing Markov analysis Mathematical models Operating costs Optimization protein manufacturing Proteins quality requirement random yield stochastic optimization
Online-Zugang:	Volltext
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