Frontispiece: Halogen Bonding Interactions of Polychlorinated Biphenyls and the Potential for Thyroid Disruption

Polychlorinated biphenyls (PCBs) are known endocrine disrupting pollutants found in microplastics. These persistent contaminants pose a threat to marine ecosystems and the human populations that depend on the sea for food. Density functional theory models provide support for a mechanism of toxicity...

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Veröffentlicht in:	Chemistry : a European journal 2020-04, Vol.26 (23), p.n/a
Hauptverfasser:	Marsan, Eric S., Bayse, Craig A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bonding Chemistry Contaminants Density functional theory Disruption Endocrine disruptors halogen bonding Human populations iodothyronine deiodinase Marine ecosystems Marine pollution Microplastics PCB Plastic pollution Pollutants polychlorinated biophenyls Polychlorinated biphenyls Thyroid Thyroid gland thyroid hormones Toxicity
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Zusammenfassung:	Polychlorinated biphenyls (PCBs) are known endocrine disrupting pollutants found in microplastics. These persistent contaminants pose a threat to marine ecosystems and the human populations that depend on the sea for food. Density functional theory models provide support for a mechanism of toxicity through which halogen bonding of PCBs to selenoprotein deiodinases (DIO) block thyroid hormone activation. Art by Jordan Shackelford. For more information see the Full Paper by E. S. Marsan and C. A. Bayse on page 5200 ff.
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.202082363