Structural Changes in the Lungs and Liver of Mice with Experimental Tuberculosis Treated with Liposome-Encapsulated Dextrazide
Male BALB/с mice were intravenously infected with Mycobacterium tuberculosis H37Rv (0.5 ml of 2-week culture). One month later, treatment with liposome-encapsulated dextrazide (LEDZ, a conjugate of isonicotinic acid hydrazide (INH) and 40 kDa oxidized dextran encapsulated in phosphatidylcholine lipo...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2020-03, Vol.168 (5), p.654-657 |
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| description | Male BALB/с mice were intravenously infected with
Mycobacterium tuberculosis
H37Rv (0.5 ml of 2-week culture). One month later, treatment with liposome-encapsulated dextrazide (LEDZ, a conjugate of isonicotinic acid hydrazide (INH) and 40 kDa oxidized dextran encapsulated in phosphatidylcholine liposomes), INH, or a combination of LEDZ with INH was started. The doses of LEDZ (liposome suspension) and INH were 0.025 ml/10 g body weight and 5 mg/kg body weight, respectively. All the substances were administered 2 times a week via inhalation or intraperitoneally (a total of 40 doses). We studied the number and the size of tuberculous granulomas, the size of destruction foci and inflammatory infiltrates in the lungs and liver, the amount of fibrous connective tissue, and the dynamic of these parameters. LEDZ+INH inhalations were most effective by the therapeutic ratios in comparison with inhalation and intraperitoneal injections of INH. |
| doi_str_mv | 10.1007/s10517-020-04773-1 |
| format | Article |
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Mycobacterium tuberculosis
H37Rv (0.5 ml of 2-week culture). One month later, treatment with liposome-encapsulated dextrazide (LEDZ, a conjugate of isonicotinic acid hydrazide (INH) and 40 kDa oxidized dextran encapsulated in phosphatidylcholine liposomes), INH, or a combination of LEDZ with INH was started. The doses of LEDZ (liposome suspension) and INH were 0.025 ml/10 g body weight and 5 mg/kg body weight, respectively. All the substances were administered 2 times a week via inhalation or intraperitoneally (a total of 40 doses). We studied the number and the size of tuberculous granulomas, the size of destruction foci and inflammatory infiltrates in the lungs and liver, the amount of fibrous connective tissue, and the dynamic of these parameters. LEDZ+INH inhalations were most effective by the therapeutic ratios in comparison with inhalation and intraperitoneal injections of INH.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-020-04773-1</identifier><identifier>PMID: 32246371</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Animals ; Antitubercular agents ; Biomedical and Life Sciences ; Biomedicine ; Body weight ; Cell Biology ; Connective tissues ; Dextran ; Dextrans - administration & dosage ; Dextrans - chemistry ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Administration Routes ; Drug Compounding ; Inflammation ; Inhalation ; Internal Medicine ; Isoniazid - administration & dosage ; Isoniazid - chemistry ; Laboratory Medicine ; Lecithin ; Liposomes ; Liposomes - administration & dosage ; Liposomes - chemistry ; Liver ; Liver - drug effects ; Liver - microbiology ; Liver - pathology ; Lung - drug effects ; Lung - microbiology ; Lung - pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mycobacterium tuberculosis - physiology ; Pathology ; Phosphatidylcholine ; Phosphatidylcholines - chemistry ; Tuberculosis ; Tuberculosis - drug therapy ; Tuberculosis - pathology</subject><ispartof>Bulletin of experimental biology and medicine, 2020-03, Vol.168 (5), p.654-657</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-5797542a0469b0794e5e7041db63b95c212838f9215f2a88932c962487bf950c3</citedby><cites>FETCH-LOGICAL-c473t-5797542a0469b0794e5e7041db63b95c212838f9215f2a88932c962487bf950c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-020-04773-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-020-04773-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32246371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shkurupy, V. A.</creatorcontrib><creatorcontrib>Cherdantseva, L. A.</creatorcontrib><creatorcontrib>Kovner, A. V.</creatorcontrib><creatorcontrib>Troitskii, A. V.</creatorcontrib><creatorcontrib>Bystrova, T. N.</creatorcontrib><creatorcontrib>Starostenko, A. A.</creatorcontrib><title>Structural Changes in the Lungs and Liver of Mice with Experimental Tuberculosis Treated with Liposome-Encapsulated Dextrazide</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Male BALB/с mice were intravenously infected with
Mycobacterium tuberculosis
H37Rv (0.5 ml of 2-week culture). One month later, treatment with liposome-encapsulated dextrazide (LEDZ, a conjugate of isonicotinic acid hydrazide (INH) and 40 kDa oxidized dextran encapsulated in phosphatidylcholine liposomes), INH, or a combination of LEDZ with INH was started. The doses of LEDZ (liposome suspension) and INH were 0.025 ml/10 g body weight and 5 mg/kg body weight, respectively. All the substances were administered 2 times a week via inhalation or intraperitoneally (a total of 40 doses). We studied the number and the size of tuberculous granulomas, the size of destruction foci and inflammatory infiltrates in the lungs and liver, the amount of fibrous connective tissue, and the dynamic of these parameters. LEDZ+INH inhalations were most effective by the therapeutic ratios in comparison with inhalation and intraperitoneal injections of INH.</description><subject>Analysis</subject><subject>Animals</subject><subject>Antitubercular agents</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body weight</subject><subject>Cell Biology</subject><subject>Connective tissues</subject><subject>Dextran</subject><subject>Dextrans - administration & dosage</subject><subject>Dextrans - chemistry</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Routes</subject><subject>Drug Compounding</subject><subject>Inflammation</subject><subject>Inhalation</subject><subject>Internal Medicine</subject><subject>Isoniazid - administration & dosage</subject><subject>Isoniazid - chemistry</subject><subject>Laboratory Medicine</subject><subject>Lecithin</subject><subject>Liposomes</subject><subject>Liposomes - administration & dosage</subject><subject>Liposomes - chemistry</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - microbiology</subject><subject>Liver - pathology</subject><subject>Lung - drug effects</subject><subject>Lung - microbiology</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mycobacterium tuberculosis - physiology</subject><subject>Pathology</subject><subject>Phosphatidylcholine</subject><subject>Phosphatidylcholines - chemistry</subject><subject>Tuberculosis</subject><subject>Tuberculosis - drug therapy</subject><subject>Tuberculosis - pathology</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1v1DAQhi0EosvCH-CALCFxS7GdOI6P1bIFpCAOLGfLcSYbV0kcbKeUHvjtuE2hVELIB3_M88545kXoJSWnlBDxNlDCqcgIIxkphMgz-ghtKE-HijH6GG1IorKiqqoT9CyEi5srKelTdJIzVpS5oBv080v0i4mL1wPe9Xo6QsB2wrEHXC_TMWA9tbi2l-Cx6_AnawB_t7HH-6sZvB1hikl4WBrwZhlcsAEfPOgI7YrVdnbBjZDtJ6PnsAy3oXdwFb2-ti08R086PQR4cbdv0dfz_WH3Ias_v_-4O6szU4g8ZlxIwQumSVHKhghZAAdBCto2Zd5IbhhlVV51klHeMV1VMmdGlqyoRNNJTky-Ra_XvLN33xYIUV24xU-ppGK5pEKmufB76qgHUHbqXPqmGW0w6qxkFU9TT3W26PQfVFotjNa4CTqb3h8I3vwl6EEPsQ9uWKJ1U3gIshU03oXgoVNzmrH2PxQl6sZytVqukuXq1nJFk-jVXWtLM0L7R_Lb4wTkKxBSKBns73v_T9pffouz8w</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Shkurupy, V. A.</creator><creator>Cherdantseva, L. A.</creator><creator>Kovner, A. V.</creator><creator>Troitskii, A. V.</creator><creator>Bystrova, T. N.</creator><creator>Starostenko, A. 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A.</au><au>Cherdantseva, L. A.</au><au>Kovner, A. V.</au><au>Troitskii, A. V.</au><au>Bystrova, T. N.</au><au>Starostenko, A. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural Changes in the Lungs and Liver of Mice with Experimental Tuberculosis Treated with Liposome-Encapsulated Dextrazide</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>168</volume><issue>5</issue><spage>654</spage><epage>657</epage><pages>654-657</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Male BALB/с mice were intravenously infected with
Mycobacterium tuberculosis
H37Rv (0.5 ml of 2-week culture). One month later, treatment with liposome-encapsulated dextrazide (LEDZ, a conjugate of isonicotinic acid hydrazide (INH) and 40 kDa oxidized dextran encapsulated in phosphatidylcholine liposomes), INH, or a combination of LEDZ with INH was started. The doses of LEDZ (liposome suspension) and INH were 0.025 ml/10 g body weight and 5 mg/kg body weight, respectively. All the substances were administered 2 times a week via inhalation or intraperitoneally (a total of 40 doses). We studied the number and the size of tuberculous granulomas, the size of destruction foci and inflammatory infiltrates in the lungs and liver, the amount of fibrous connective tissue, and the dynamic of these parameters. LEDZ+INH inhalations were most effective by the therapeutic ratios in comparison with inhalation and intraperitoneal injections of INH.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32246371</pmid><doi>10.1007/s10517-020-04773-1</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bulletin of experimental biology and medicine, 2020-03, Vol.168 (5), p.654-657 |
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| subjects | Analysis Animals Antitubercular agents Biomedical and Life Sciences Biomedicine Body weight Cell Biology Connective tissues Dextran Dextrans - administration & dosage Dextrans - chemistry Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Routes Drug Compounding Inflammation Inhalation Internal Medicine Isoniazid - administration & dosage Isoniazid - chemistry Laboratory Medicine Lecithin Liposomes Liposomes - administration & dosage Liposomes - chemistry Liver Liver - drug effects Liver - microbiology Liver - pathology Lung - drug effects Lung - microbiology Lung - pathology Male Mice Mice, Inbred BALB C Mycobacterium tuberculosis - physiology Pathology Phosphatidylcholine Phosphatidylcholines - chemistry Tuberculosis Tuberculosis - drug therapy Tuberculosis - pathology |
| title | Structural Changes in the Lungs and Liver of Mice with Experimental Tuberculosis Treated with Liposome-Encapsulated Dextrazide |
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