Synthesis and biological effects of naphthalene-chalcone derivatives
In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds 2a–2u displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds 2h , 2o , 2t , and 2u exhibited a good antidepressant ef...
Gespeichert in:
| Veröffentlicht in: | Medicinal chemistry research 2020-05, Vol.29 (5), p.877-886 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 886 |
|---|---|
| container_issue | 5 |
| container_start_page | 877 |
| container_title | Medicinal chemistry research |
| container_volume | 29 |
| creator | Jin, Qing-Hao Chen, Hong-Hai Chen, Wen-Bo Fu, Zhi-Yang Guan, Li-Ping Jiang, Hai-Ying |
| description | In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds
2a–2u
displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds
2h
,
2o
,
2t
, and
2u
exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30 mg/kg. Compounds
2h
,
2o
,
2t
, and
2u
but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound
2o
is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds
2a–2u
also showed the analgesic and anti-inflammatory effects at 30 mg/kg. |
| doi_str_mv | 10.1007/s00044-020-02525-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2391222537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2391222537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-ceb424646685f885ae1d259b2123d3523883ef6919857a83ece0c2fec8feb27c3</originalsourceid><addsrcrecordid>eNp9UMtOwzAQtBBIlMIPcIrE2bB-Jc4RladUiQNwthxn3aYKTrHTSv17DEHixmE1I-3M7mgIuWRwzQCqmwQAUlLgkEdxReURmTGlJNWMw3HmkHneiFNyltIGQFQg1YzcvR7CuMbUpcKGtmi6oR9WnbN9gd6jG1Mx-CLY7Xpc2x4DUpfRDQGLFmO3t2O3x3ROTrztE1784py8P9y_LZ7o8uXxeXG7pE6weqQOG8llKctSK6-1ssharuqGMy5akbNpLdCXNau1qmzmDsHxnEJ7bHjlxJxcTXe3cfjcYRrNZtjFkF8aLmrGOVeiyio-qVwcUorozTZ2HzYeDAPz3ZaZ2jK5LfPTlpHZJCZTyuKwwvh3-h_XFxMLbKU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2391222537</pqid></control><display><type>article</type><title>Synthesis and biological effects of naphthalene-chalcone derivatives</title><source>SpringerNature Journals</source><creator>Jin, Qing-Hao ; Chen, Hong-Hai ; Chen, Wen-Bo ; Fu, Zhi-Yang ; Guan, Li-Ping ; Jiang, Hai-Ying</creator><creatorcontrib>Jin, Qing-Hao ; Chen, Hong-Hai ; Chen, Wen-Bo ; Fu, Zhi-Yang ; Guan, Li-Ping ; Jiang, Hai-Ying</creatorcontrib><description>In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds
2a–2u
displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds
2h
,
2o
,
2t
, and
2u
exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30 mg/kg. Compounds
2h
,
2o
,
2t
, and
2u
but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound
2o
is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds
2a–2u
also showed the analgesic and anti-inflammatory effects at 30 mg/kg.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-020-02525-4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analgesics ; Antidepressants ; Biochemistry ; Biological effects ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Central nervous system ; Derivatives ; Field tests ; Inflammation ; Locomotor activity ; Naphthalene ; Norepinephrine ; Open-field behavior ; Original Research ; Pharmacology/Toxicology ; Serotonin</subject><ispartof>Medicinal chemistry research, 2020-05, Vol.29 (5), p.877-886</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-ceb424646685f885ae1d259b2123d3523883ef6919857a83ece0c2fec8feb27c3</citedby><cites>FETCH-LOGICAL-c319t-ceb424646685f885ae1d259b2123d3523883ef6919857a83ece0c2fec8feb27c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00044-020-02525-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00044-020-02525-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Jin, Qing-Hao</creatorcontrib><creatorcontrib>Chen, Hong-Hai</creatorcontrib><creatorcontrib>Chen, Wen-Bo</creatorcontrib><creatorcontrib>Fu, Zhi-Yang</creatorcontrib><creatorcontrib>Guan, Li-Ping</creatorcontrib><creatorcontrib>Jiang, Hai-Ying</creatorcontrib><title>Synthesis and biological effects of naphthalene-chalcone derivatives</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds
2a–2u
displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds
2h
,
2o
,
2t
, and
2u
exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30 mg/kg. Compounds
2h
,
2o
,
2t
, and
2u
but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound
2o
is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds
2a–2u
also showed the analgesic and anti-inflammatory effects at 30 mg/kg.</description><subject>Analgesics</subject><subject>Antidepressants</subject><subject>Biochemistry</subject><subject>Biological effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Central nervous system</subject><subject>Derivatives</subject><subject>Field tests</subject><subject>Inflammation</subject><subject>Locomotor activity</subject><subject>Naphthalene</subject><subject>Norepinephrine</subject><subject>Open-field behavior</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Serotonin</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UMtOwzAQtBBIlMIPcIrE2bB-Jc4RladUiQNwthxn3aYKTrHTSv17DEHixmE1I-3M7mgIuWRwzQCqmwQAUlLgkEdxReURmTGlJNWMw3HmkHneiFNyltIGQFQg1YzcvR7CuMbUpcKGtmi6oR9WnbN9gd6jG1Mx-CLY7Xpc2x4DUpfRDQGLFmO3t2O3x3ROTrztE1784py8P9y_LZ7o8uXxeXG7pE6weqQOG8llKctSK6-1ssharuqGMy5akbNpLdCXNau1qmzmDsHxnEJ7bHjlxJxcTXe3cfjcYRrNZtjFkF8aLmrGOVeiyio-qVwcUorozTZ2HzYeDAPz3ZaZ2jK5LfPTlpHZJCZTyuKwwvh3-h_XFxMLbKU</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Jin, Qing-Hao</creator><creator>Chen, Hong-Hai</creator><creator>Chen, Wen-Bo</creator><creator>Fu, Zhi-Yang</creator><creator>Guan, Li-Ping</creator><creator>Jiang, Hai-Ying</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20200501</creationdate><title>Synthesis and biological effects of naphthalene-chalcone derivatives</title><author>Jin, Qing-Hao ; Chen, Hong-Hai ; Chen, Wen-Bo ; Fu, Zhi-Yang ; Guan, Li-Ping ; Jiang, Hai-Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-ceb424646685f885ae1d259b2123d3523883ef6919857a83ece0c2fec8feb27c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analgesics</topic><topic>Antidepressants</topic><topic>Biochemistry</topic><topic>Biological effects</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Central nervous system</topic><topic>Derivatives</topic><topic>Field tests</topic><topic>Inflammation</topic><topic>Locomotor activity</topic><topic>Naphthalene</topic><topic>Norepinephrine</topic><topic>Open-field behavior</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Serotonin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Qing-Hao</creatorcontrib><creatorcontrib>Chen, Hong-Hai</creatorcontrib><creatorcontrib>Chen, Wen-Bo</creatorcontrib><creatorcontrib>Fu, Zhi-Yang</creatorcontrib><creatorcontrib>Guan, Li-Ping</creatorcontrib><creatorcontrib>Jiang, Hai-Ying</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Qing-Hao</au><au>Chen, Hong-Hai</au><au>Chen, Wen-Bo</au><au>Fu, Zhi-Yang</au><au>Guan, Li-Ping</au><au>Jiang, Hai-Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and biological effects of naphthalene-chalcone derivatives</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2020-05-01</date><risdate>2020</risdate><volume>29</volume><issue>5</issue><spage>877</spage><epage>886</epage><pages>877-886</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds
2a–2u
displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds
2h
,
2o
,
2t
, and
2u
exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30 mg/kg. Compounds
2h
,
2o
,
2t
, and
2u
but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound
2o
is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds
2a–2u
also showed the analgesic and anti-inflammatory effects at 30 mg/kg.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-020-02525-4</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1054-2523 |
| ispartof | Medicinal chemistry research, 2020-05, Vol.29 (5), p.877-886 |
| issn | 1054-2523 1554-8120 |
| language | eng |
| recordid | cdi_proquest_journals_2391222537 |
| source | SpringerNature Journals |
| subjects | Analgesics Antidepressants Biochemistry Biological effects Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system Derivatives Field tests Inflammation Locomotor activity Naphthalene Norepinephrine Open-field behavior Original Research Pharmacology/Toxicology Serotonin |
| title | Synthesis and biological effects of naphthalene-chalcone derivatives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T22%3A04%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20biological%20effects%20of%20naphthalene-chalcone%20derivatives&rft.jtitle=Medicinal%20chemistry%20research&rft.au=Jin,%20Qing-Hao&rft.date=2020-05-01&rft.volume=29&rft.issue=5&rft.spage=877&rft.epage=886&rft.pages=877-886&rft.issn=1054-2523&rft.eissn=1554-8120&rft_id=info:doi/10.1007/s00044-020-02525-4&rft_dat=%3Cproquest_cross%3E2391222537%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2391222537&rft_id=info:pmid/&rfr_iscdi=true |