JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8

Background Jumonji domain-containing protein 2A (JMJD2A) of the JMJD2 family of histone lysine demethylases has been implicated in tumorigenesis. However, its expression and role in gastric cancer (GC) drug resistance remain unknown. Here, we investigated the role of JMJD2A in GC chemotherapeutic su...

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Veröffentlicht in:	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2020-05, Vol.23 (3), p.426-436
Hauptverfasser:	Nakagawa, Tadahiko, Sato, Yasushi, Tanahashi, Toshihito, Mitsui, Yasuhiro, Kida, Yoshifumi, Fujino, Yasuteru, Hirata, Misato, Kitamura, Shinji, Miyamoto, Hiroshi, Okamoto, Koichi, Muguruma, Naoki, Bando, Yoshimi, Takayama, Tetsuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Biomarkers, Tumor - metabolism Cancer Research Carrier Proteins - genetics Carrier Proteins - metabolism Cell Proliferation Cell viability Chemotherapy Cisplatin Cisplatin - administration & dosage Docetaxel - administration & dosage Drug Combinations Drug development Drug resistance Gastric cancer Gastroenterology Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene regulation Humans Immunohistochemistry Immunoprecipitation Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Lysine Medicine Medicine & Public Health Oncology Original Article Oxonic Acid - administration & dosage Prognosis siRNA Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Surgical Oncology Tegafur - administration & dosage Therapeutic applications Tumor Cells, Cultured Tumorigenesis
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