JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor

The human polyomavirus, JCPyV, is the causative agent of progressive multifocal leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients. Initial infection with JCPyV is common and the virus establishes a long-term persistent infection in the urogenital system of 50-70% of the huma...

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Veröffentlicht in:	PLoS pathogens 2020-03, Vol.16 (3), p.e1008371-e1008371, Article 1008371
Hauptverfasser:	O'Hara, Bethany A., Morris-Love, Jenna, Gee, Gretchen, Haley, Sheila A., Atwood, Walter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antisera Astrocytes Attachment Biochemistry Biology and Life Sciences Biotechnology industries Brain Cell Line, Transformed Central nervous system Choroid plexus Choroid Plexus - metabolism Choroid Plexus - pathology Choroid Plexus - virology Clathrin Cytochrome Disease susceptibility Disease transmission Diseases Encephalitis Endocytosis Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - virology Extracellular vesicles Extracellular Vesicles - metabolism Extracellular Vesicles - pathology Extracellular Vesicles - virology Glia Glial cells Health aspects Human populations Human tissues Humans Infection Infections JC Virus - metabolism Leukoencephalopathy Leukoencephalopathy, Progressive Multifocal - metabolism Leukoencephalopathy, Progressive Multifocal - pathology Life Sciences & Biomedicine Medicine and Health Sciences Microbiology Molecular biology Nanoparticles Neuroglia - metabolism Neuroglia - pathology Neuroglia - virology Oligodendrocytes Parasitology Parenchyma Progressive multifocal leukoencephalopathy Proteins Receptors Receptors, Virus - metabolism Science & Technology Transmission electron microscopy United States Vesicles Viral infections Virology Virus attachment Virus diseases Viruses
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