Water soluble palladium() and platinum() acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

Bis-ADC complexes cis -[Pd{C(NHC 6 H 4 NH 2 )N(H)R} 2 ]Cl 2 (R = Xyl 4a , Cy 4b , C 6 H 4 -4-F 4c ) and cis -[Pt{C(NHC 6 H 4 NH 2 )N(H)R} 2 ]Cl 2 (R = Xyl 5a , Cy 5b , C 6 H 4 -4-F 5c ) were synthesized via the metal-mediated coupling of two isocyanide ligands in cis -[MCl 2 (CNR) 2 ] (M = Pd, Pt; R...

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