Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Cholangiocarcinoma

Cholangiocarcinoma (CCA), a malignant tumor that occurs in the epithelium of the biliary tract, has a very poor prognosis because affected patients are frequently diagnosed at an advanced stage and recurrence after resection is common. Over the last two decades, our understanding of the molecular bi...

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Veröffentlicht in:	Molecular diagnosis & therapy 2020-04, Vol.24 (2), p.175-184
Hauptverfasser:	Mastoraki, Aikaterini, Schizas, Dimitrios, Charalampakis, Nikolaos, Naar, Leon, Ioannidi, Maria, Tsilimigras, Diamantis, Sotiropoulou, Maria, Moris, Dimitrios, Vassiliu, Pantelis, Felekouras, Evangelos
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Angiogenesis Anticancer properties Antineoplastic drugs Antitumor agents Apoptosis Bile Duct Neoplasms - blood supply Bile Duct Neoplasms - drug therapy Bile Duct Neoplasms - enzymology Biliary tract Biomedical and Life Sciences Biomedicine Blood vessels Cancer Research Cancer therapies Carcinogenesis Carcinogens Cell cycle Cell growth Chemotherapy Cholangiocarcinoma Cholangiocarcinoma - blood supply Cholangiocarcinoma - drug therapy Cholangiocarcinoma - enzymology Chromatin Clinical trials Clinical Trials as Topic Cyclin-dependent kinases Cytotoxicity Deacetylation Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA methylation DNA repair DNA topoisomerase inhibitors Drugs Epigenetics Epithelium Equilibrium Gene expression Gene Expression Regulation, Neoplastic - drug effects Growth factors Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Histone Deacetylases - genetics Histone Deacetylases - metabolism Histones Human Genetics Humans Hypoxia Hypoxia-inducible factor 1 Inhibitors Intercalating agents Ionizing radiation Kinases Laboratory Medicine Ligands Malignancy Medical prognosis Metastases Molecular biology Molecular Medicine Molecular Targeted Therapy Nitric oxide Nitric-oxide synthase Pharmacotherapy Prognosis Proteins Review Article Survival Analysis Treatment Outcome Tumor necrosis factor-TNF Vascular endothelial growth factor
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