Cellular and molecular effects of silymarin on the transdifferentiation processes of LX-2 cells and its connection with lipid metabolism

Fibrosis process in the liver is a clinical condition established in response to chronic lesions and may be reversible in many situations. In this process, hepatic stellate cells (HSCs) activate and produce extracellular matrix compounds. During fibrosis, the lipid metabolism is also altered and con...

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Veröffentlicht in:	Molecular and cellular biochemistry 2020-05, Vol.468 (1-2), p.129-142
Hauptverfasser:	Silva, Caio Mateus, Ferrari, Gustavo Duarte, Alberici, Luciane Carla, Malaspina, Osmar, Moraes, Karen C. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - drug effects Actin Cytoskeleton - metabolism Actins - genetics Actins - metabolism Biochemistry Biomedical and Life Sciences Cardiology Cell activation Cell Line Cell Transdifferentiation - drug effects Chromatography, Gas Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Connective tissue growth factor Connective Tissue Growth Factor - genetics Connective Tissue Growth Factor - metabolism Dimethyl sulfoxide Dimethyl Sulfoxide - toxicity Ethylenediaminetetraacetic acid Extracellular matrix Fatty Acid Synthase, Type I - genetics Fatty Acid Synthase, Type I - metabolism Fatty acids Fibrosis Filaments Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - enzymology Hepatic Stellate Cells - metabolism Humans Life Sciences Lipid metabolism Lipid Metabolism - genetics Lipids Liver Liver - metabolism Liver - pathology Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver diseases Mass Spectrometry Medical Biochemistry Medical research Medicine, Experimental Metabolism Muscle proteins Oncology Phenotypes Physiological aspects Protective Agents - pharmacology Protein biosynthesis Silymarin Silymarin - pharmacology Stellate cells Synthesis Triglycerides Triglycerides - metabolism
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