Overexpression of MYBL2 promotes proliferation and migration of non-small-cell lung cancer via upregulating NCAPH

MYB Proto-Oncogene Like 2 (MYBL2) is a highly conserved member of the Myb family of transcription factors and plays a critical role in regulating cell proliferation and survival. Here we show that overexpression of MYBL2 is frequently observed in lung adenocarcinoma (LUAD) and significantly correlat...

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Veröffentlicht in:	Molecular and cellular biochemistry 2020-05, Vol.468 (1-2), p.185-193
Hauptverfasser:	Xiong, Yu-Chao, Wang, Jiao, Cheng, Yong, Zhang, Xin-Yi, Ye, Xiao-Qun
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Adenocarcinoma Apoptosis Apoptosis - genetics Biochemistry Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Carcinogens - metabolism Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Cardiology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell death Cell growth Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Cell survival Chromatin Chromatin Immunoprecipitation Condensin DNA binding proteins Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Knockdown Techniques Genes Health aspects Humans Immunoprecipitation Life Sciences Lung cancer Lung cancer, Non-small cell Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Medical Biochemistry Non-small cell lung carcinoma Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology Protein Binding Survival Therapeutic applications Trans-Activators - genetics Trans-Activators - metabolism Transcription factors Transcriptional Activation - genetics Up-Regulation
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