Sustained release and enhanced oral bioavailability of rivaroxaban by PLGA nanoparticles with no food effect

The purpose of the currents study was to enhance bioavailability of rivaroxaban (RXB) and reduce the food effect. RXB loaded PLGA nanoparticles (RXB-PLGA-NPs) were prepared by emulsion solvent evaporation method and optimized using central composite design (CDD). The optimized RXB-PLGA-NPs (F8) with...

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Veröffentlicht in:	Journal of thrombosis and thrombolysis 2020-04, Vol.49 (3), p.404-412
Hauptverfasser:	Anwer, Md. Khalid, Mohammad, Muqtader, Iqbal, Muzaffar, Ansari, Mohd Nazam, Ezzeldin, Essam, Fatima, Farhat, Alshahrani, Saad M., Aldawsari, Mohammed F., Alalaiwe, Ahmed, Alzahrani, Aiman A., Aldayel, Abdullah M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Bioavailability Biological Availability Cardiology Controlled release Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology Evaporation Food Food-Drug Interactions Glucose Hematology Male Medicine Medicine & Public Health Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Pharmacokinetics Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Polylactic Acid-Polyglycolic Acid Copolymer - pharmacokinetics Polylactic Acid-Polyglycolic Acid Copolymer - pharmacology Polylactide-co-glycolide Rats Rats, Wistar Rivaroxaban - chemistry Rivaroxaban - pharmacokinetics Rivaroxaban - pharmacology
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