A Glycosylated Cationic Block Poly(β‐peptide) Reverses Intrinsic Antibiotic Resistance in All ESKAPE Gram‐Negative Bacteria

Carbapenem‐resistant Gram‐negative bacteria (GNB) are heading the list of pathogens for which antibiotics are the most critically needed. Many antibiotics are either unable to penetrate the outer‐membrane or are excluded by efflux mechanisms. Here, we report a cationic block β‐peptide (PAS8‐b‐PDM12)...

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Veröffentlicht in:	Angewandte Chemie 2020-04, Vol.132 (17), p.6886-6893
Hauptverfasser:	Si, Zhangyong, Lim, Hui Wen, Tay, Moon Y. F., Du, Yu, Ruan, Lin, Qiu, Haofeng, Zamudio‐Vazquez, Rubí, Reghu, Sheethal, Chen, Yahua, Tiong, Wen Shuo, Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Zhu, Yabin, Gan, Yunn‐Hwen, Chi, Yonggui Robin, Duan, Hongwei, Bazan, Guillermo C., Greenberg, E. Peter, Chan‐Park, Mary B., Pethe, Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotic resistance Antibiotics Antibiotikaresistenz Bacteria Carbapeneme Cations Chemistry Colistin Deactivation Drug resistance Efflux Effluxpumpen Electrochemical potential Electrochemistry Gram-negative bacteria Hydrophobicity Medizinische Chemie Membranes Peptides Sensitizing β-Peptide
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