Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle

Acetaldehyde dehydrogenase 2 (ALDH2) is an enzyme involved in redox homeostasis as well as the detoxification process in alcohol metabolism. Nearly 8% of the world's population have an inactivating mutation in the gene. However, the expression patterns and specific functions of ALDH2 in skeleta...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2020-04, Vol.318 (4), p.R677-R690
Hauptverfasser:	Wakabayashi, Yuka, Tamura, Yuki, Kouzaki, Karina, Kikuchi, Naoki, Hiranuma, Kenji, Menuki, Kunitaka, Tajima, Takafumi, Yamanaka, Yoshiaki, Sakai, Akinori, Nakayama, Keiichi I, Kawamoto, Toshihiro, Kitagawa, Kyoko, Nakazato, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde Acetaldehyde dehydrogenase Adaptation Aldehyde dehydrogenase Aldehyde dehydrogenase (NAD) Dehydrogenase Dehydrogenases Depolarization Detoxification Emission Enzymatic activity Gastrocnemius muscle Gene expression Glycolysis Homeostasis Indicator species Markers Metabolism Mitochondria Muscles Musculoskeletal system Mutation Oxidation Oxidation rate Protease Protein folding Proteins Quality control Reactive oxygen species Respiratory function Serine Serine proteinase Skeletal muscle
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