Anti‐MDA5‐associated dermatomyositis
Anti‐MDA5‐associated dermatomyositis (MDA5‐associated DM) is an uncommon presentation of idiopathic inflammatory myositis, typically amyopathic, associated with rapidly progressive, treatment refractory interstitial lung disease and poor prognosis, particularly in patients with concomitant rapidly p...
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Veröffentlicht in: | Internal medicine journal 2020-04, Vol.50 (4), p.484-487 |
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creator | Gupta, Rajiv Kumar, Sunil Gow, Peter (Hsien‐Cheng) Chang, Leon Yen, Linda |
description | Anti‐MDA5‐associated dermatomyositis (MDA5‐associated DM) is an uncommon presentation of idiopathic inflammatory myositis, typically amyopathic, associated with rapidly progressive, treatment refractory interstitial lung disease and poor prognosis, particularly in patients with concomitant rapidly progressive interstitial lung disease (RP‐ILD). We report two cases of MDA5‐associated DM with fatal outcome in one of the patients, despite ‘aggressive triple therapy’ for RP‐ILD. |
doi_str_mv | 10.1111/imj.14789 |
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We report two cases of MDA5‐associated DM with fatal outcome in one of the patients, despite ‘aggressive triple therapy’ for RP‐ILD.</description><identifier>ISSN: 1444-0903</identifier><identifier>EISSN: 1445-5994</identifier><identifier>DOI: 10.1111/imj.14789</identifier><identifier>PMID: 32270621</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>anti‐MDA5‐associated dermatomyositis ; Autoantibodies ; cyclosporine ; Dermatomyositis ; Dermatomyositis - complications ; Dermatomyositis - diagnosis ; Dermatomyositis - drug therapy ; General & Internal Medicine ; Humans ; Inflammation ; inflammatory myopathy ; intravenous immunoglobulins ; Life Sciences & Biomedicine ; Lung diseases ; Lung Diseases, Interstitial - diagnostic imaging ; Lung Diseases, Interstitial - etiology ; MDA5‐associated interstitial lung disease ; Medicine, General & Internal ; Myositis ; Science & Technology</subject><ispartof>Internal medicine journal, 2020-04, Vol.50 (4), p.484-487</ispartof><rights>2020 Royal Australasian College of Physicians</rights><rights>2020 Royal Australasian College of Physicians.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000524488000015</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3539-e1809c6b4d1232f33e6b2568aead6c3bd2b3fb81de1d4b912a602954f54b32993</citedby><cites>FETCH-LOGICAL-c3539-e1809c6b4d1232f33e6b2568aead6c3bd2b3fb81de1d4b912a602954f54b32993</cites><orcidid>0000-0001-5908-4737</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fimj.14789$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fimj.14789$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,28257,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32270621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Rajiv</creatorcontrib><creatorcontrib>Kumar, Sunil</creatorcontrib><creatorcontrib>Gow, Peter</creatorcontrib><creatorcontrib>(Hsien‐Cheng) Chang, Leon</creatorcontrib><creatorcontrib>Yen, Linda</creatorcontrib><title>Anti‐MDA5‐associated dermatomyositis</title><title>Internal medicine journal</title><addtitle>INTERN MED J</addtitle><addtitle>Intern Med J</addtitle><description>Anti‐MDA5‐associated dermatomyositis (MDA5‐associated DM) is an uncommon presentation of idiopathic inflammatory myositis, typically amyopathic, associated with rapidly progressive, treatment refractory interstitial lung disease and poor prognosis, particularly in patients with concomitant rapidly progressive interstitial lung disease (RP‐ILD). We report two cases of MDA5‐associated DM with fatal outcome in one of the patients, despite ‘aggressive triple therapy’ for RP‐ILD.</description><subject>anti‐MDA5‐associated dermatomyositis</subject><subject>Autoantibodies</subject><subject>cyclosporine</subject><subject>Dermatomyositis</subject><subject>Dermatomyositis - complications</subject><subject>Dermatomyositis - diagnosis</subject><subject>Dermatomyositis - drug therapy</subject><subject>General & Internal Medicine</subject><subject>Humans</subject><subject>Inflammation</subject><subject>inflammatory myopathy</subject><subject>intravenous immunoglobulins</subject><subject>Life Sciences & Biomedicine</subject><subject>Lung diseases</subject><subject>Lung Diseases, Interstitial - diagnostic imaging</subject><subject>Lung Diseases, Interstitial - etiology</subject><subject>MDA5‐associated interstitial lung disease</subject><subject>Medicine, General & Internal</subject><subject>Myositis</subject><subject>Science & Technology</subject><issn>1444-0903</issn><issn>1445-5994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqN0E1LwzAYB_AgipvTg19ABC8T6Zb3JsdR3yYbXvRckjaFjLWZTYvs5kfwM_pJzNa5gyCYy5PD73n48wfgHMERCm9sy8UI0VjIA9BHlLKISUkPt38aQQlJD5x4v4AQxUTSY9AjGMeQY9QHw0nV2K-Pz_nthIWhvHeZVY3JL3NTl6px5dp521h_Co4KtfTmbDcH4PX-7iV5jGbPD9NkMosywoiMDBJQZlzTHGGCC0IM15hxoYzKeUZ0jjUptEC5QTnVEmHFIZaMFoxqgqUkAzDs7q5q99Ya36Sl9ZlZLlVlXOtTTISAkBDIAr36RReurauQbqNiGkvBeVDXncpq531tinRV21LV6xTBdFNfGupLt_UFe7G72OrS5Hv501cAogPvRrvCZ9ZUmdkzCCHDlG4Chq5ZYhvVWFclrq2asHrz_9Wgxzttl2b9d-R0On_qsn8DFj-ZRw</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Gupta, Rajiv</creator><creator>Kumar, Sunil</creator><creator>Gow, Peter</creator><creator>(Hsien‐Cheng) Chang, Leon</creator><creator>Yen, Linda</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5908-4737</orcidid></search><sort><creationdate>202004</creationdate><title>Anti‐MDA5‐associated dermatomyositis</title><author>Gupta, Rajiv ; Kumar, Sunil ; Gow, Peter ; (Hsien‐Cheng) Chang, Leon ; Yen, Linda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-e1809c6b4d1232f33e6b2568aead6c3bd2b3fb81de1d4b912a602954f54b32993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>anti‐MDA5‐associated dermatomyositis</topic><topic>Autoantibodies</topic><topic>cyclosporine</topic><topic>Dermatomyositis</topic><topic>Dermatomyositis - complications</topic><topic>Dermatomyositis - diagnosis</topic><topic>Dermatomyositis - drug therapy</topic><topic>General & Internal Medicine</topic><topic>Humans</topic><topic>Inflammation</topic><topic>inflammatory myopathy</topic><topic>intravenous immunoglobulins</topic><topic>Life Sciences & Biomedicine</topic><topic>Lung diseases</topic><topic>Lung Diseases, Interstitial - diagnostic imaging</topic><topic>Lung Diseases, Interstitial - etiology</topic><topic>MDA5‐associated interstitial lung disease</topic><topic>Medicine, General & Internal</topic><topic>Myositis</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Rajiv</creatorcontrib><creatorcontrib>Kumar, Sunil</creatorcontrib><creatorcontrib>Gow, Peter</creatorcontrib><creatorcontrib>(Hsien‐Cheng) Chang, Leon</creatorcontrib><creatorcontrib>Yen, Linda</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Internal medicine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Rajiv</au><au>Kumar, Sunil</au><au>Gow, Peter</au><au>(Hsien‐Cheng) Chang, Leon</au><au>Yen, Linda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti‐MDA5‐associated dermatomyositis</atitle><jtitle>Internal medicine journal</jtitle><stitle>INTERN MED J</stitle><addtitle>Intern Med J</addtitle><date>2020-04</date><risdate>2020</risdate><volume>50</volume><issue>4</issue><spage>484</spage><epage>487</epage><pages>484-487</pages><issn>1444-0903</issn><eissn>1445-5994</eissn><abstract>Anti‐MDA5‐associated dermatomyositis (MDA5‐associated DM) is an uncommon presentation of idiopathic inflammatory myositis, typically amyopathic, associated with rapidly progressive, treatment refractory interstitial lung disease and poor prognosis, particularly in patients with concomitant rapidly progressive interstitial lung disease (RP‐ILD). 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subjects | anti‐MDA5‐associated dermatomyositis Autoantibodies cyclosporine Dermatomyositis Dermatomyositis - complications Dermatomyositis - diagnosis Dermatomyositis - drug therapy General & Internal Medicine Humans Inflammation inflammatory myopathy intravenous immunoglobulins Life Sciences & Biomedicine Lung diseases Lung Diseases, Interstitial - diagnostic imaging Lung Diseases, Interstitial - etiology MDA5‐associated interstitial lung disease Medicine, General & Internal Myositis Science & Technology |
title | Anti‐MDA5‐associated dermatomyositis |
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