Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution

Ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution (DYRKR) of α-substituted-β-keto arylphosphonates was developed as a generic and stereoselective approach to synthesize chiral α-substituted-β-hydroxy arylphosphonates, with moderate-to-excellent isolated yield (up to 96%), good-to-e...

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Veröffentlicht in:	Organic & biomolecular chemistry 2020-04, Vol.18 (14), p.2672-2677
Hauptverfasser:	Wang, Zexu, Zeng, Yiping, Wu, Xiaofan, Li, Zihan, Tao, Yuan, Yu, Xiaomin, Huang, Zedu, Chen, Fener
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Crystallography Enantiomers Molecular biology Stereoselectivity Substitutes Substrates
Online-Zugang:	Volltext
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