Reduction of intraocular pressure using timolol orally dissolving strips in the treatment of induced primary open-angle glaucoma in rabbits

Abstract Objective To enhance bioavailability of timolol (TML) and utilize alternatives for traditional eye drops for more patient compliance, this study was aiming to develop biodegradable orally dissolving strips (ODSs) of TML for treatment of primary open-angle glaucoma (POAG). Methods Novel ODSs...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2020-05, Vol.72 (5), p.682-698
Hauptverfasser:	El-Feky, Yasmin A, Mostafa, Dalia A, Al-Sawahli, Majid M, El-Telbany, Rania Farag A, Zakaria, Sherin, Fayez, Ahmed M, Ahmed, Kawkab A, Alolayan, Ebtesam M, El-Telbany, Dalia Farag A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antihypertensive Agents - administration & dosage Antihypertensive Agents - pharmacokinetics Antihypertensive Agents - therapeutic use Bioavailability Biodegradability Biological Availability Cornea Drug Compounding Drug Delivery Systems Drug Liberation Drug Stability Eye fast release Glaucoma Glaucoma, Open-Angle - drug therapy Glaucoma, Open-Angle - metabolism Glaucoma, Open-Angle - pathology Glaucoma, Open-Angle - physiopathology In Vitro Techniques intraocular pressure Intraocular Pressure - drug effects orally dissolving strips Oxidative stress Oxidative Stress - drug effects Polymers - pharmacokinetics primary open‐angle glaucoma Rabbits Timolol Timolol - administration & dosage Timolol - pharmacokinetics Timolol - therapeutic use
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