Metabolism and pharmacokinetics characterization of metarrestin in multiple species

Purpose Metarrestin is a first-in-class pyrrolo-pyrimidine-derived small molecule targeting a marker of genome organization associated with metastasis and is currently in preclinical development as an anti-cancer agent. Here, we report the in vitro ADME characteristics and in vivo pharmacokinetic be...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2020-04, Vol.85 (4), p.805-816
Hauptverfasser:	Padilha, Elias C., Shah, Pranav, Wang, Amy Q., Singleton, Marc D., Hughes, Emma A., Li, Dandan, Rice, Kelly A., Konrath, Kylie M., Patnaik, Samarjit, Marugan, Juan, Rudloff, Udo, Xu, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anticancer properties Bile Bioavailability Biotransformation Cancer Research Cytochrome Cytochrome P-450 Enzyme Inhibitors - administration & dosage Cytochrome P-450 Enzyme Inhibitors - pharmacokinetics Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Cytochromes P450 Dogs Drug Evaluation, Preclinical Drug interaction Drug Interactions Efflux Excretion Female Genomes Haplorhini Hepatocytes Humans In vivo methods and tests Intravenous administration Liver Male Medicine Medicine & Public Health Metabolism Metastases Mice Mice, Inbred C57BL Microsomes Microsomes, Liver - drug effects Microsomes, Liver - metabolism Monkeys Oncology Oral administration Original Article Permeability Pharmacokinetics Pharmacology Pharmacology/Toxicology Pyrimidines - administration & dosage Pyrimidines - pharmacokinetics Pyrroles - administration & dosage Pyrroles - pharmacokinetics Rats Rats, Sprague-Dawley Solubility Species Species Specificity Swine Swine, Miniature Tissue Distribution
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