Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice

Pituitary adenylate cyclase-activating polypeptide (PACAP) is abundantly expressed in the hypothalamus and contributes to hypothalamic functions, including appetite regulation. Although food intake is suggested to be decreased in PACAP (−/−) mice, the detailed mechanisms are still being discussed. W...

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Veröffentlicht in:	Molecular neurobiology 2020-04, Vol.57 (4), p.2101-2114
Hauptverfasser:	Nguyen, Thanh Trung, Kambe, Yuki, Kurihara, Takashi, Nakamachi, Tomoya, Shintani, Norihito, Hashimoto, Hitoshi, Miyata, Atsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Agouti-Related Protein - genetics Agouti-Related Protein - metabolism Animals Appetite Biomedical and Life Sciences Biomedicine Body weight Brain Cell Biology Circadian Rhythm Diurnal Drug development Fasting Feeding Behavior Food Food consumption Food intake Gene expression Hypothalamus (ventromedial) Intracerebroventricular administration Mice Neurobiology Neurology Neuropeptides - metabolism Neurosciences Nocturnal Paraventricular Hypothalamic Nucleus - metabolism Pituitary adenylate cyclase-activating polypeptide Pituitary Adenylate Cyclase-Activating Polypeptide - deficiency Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism Polypeptides Pro-Opiomelanocortin - metabolism Proopiomelanocortin RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Ventromedial Hypothalamic Nucleus - metabolism
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