Reduced response inhibition after exposure to drug-related cues in male heroin abstainers
Rationale Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequen...
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| Veröffentlicht in: | Psychopharmacology 2020-04, Vol.237 (4), p.1055-1062 |
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| creator | Su, Bobo Li, Shaomei Yang, Ling Zheng, Meihong |
| description | Rationale
Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibition in heroin users following abstinence.
Objectives
The present study aimed to investigate how drug-related cues with different durations between stimulus presentations, referred to as stimulus onset asynchronies (SOAs), affect subsequent response inhibition in heroin abstainers (HAs) with different length of abstinence.
Methods
Sixty-seven male HAs performed a modified Go/NoGo task in which a motor response to frequent Go targets and no response to rare NoGo targets were required and a Go or NoGo target was displayed after either a heroin-related or a neutral picture presented for the 200 ms and 600 ms SOAs.
Results
The HAs responded significantly faster to Go targets following the neutral pictures for the 600 ms SOA compared to other conditions. They also made more commission errors following heroin-related pictures compared to neutral pictures regardless of the SOAs. The shorter-term HAs made more commission errors compared to the longer-term HAs following the 200 ms SOA, and it was only a trend when the SOA was 600 ms. Additionally, negative correlations between the duration of current abstinence and commission errors were observed following cues with the 200 ms SOA.
Conclusions
Impaired response inhibition in HAs can be improved through protracted drug abstinence. However, that effect can be reduced by exposure to drug-related cues, which may increase the risk of relapse. |
| doi_str_mv | 10.1007/s00213-019-05434-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2385255220</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A619241411</galeid><sourcerecordid>A619241411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-1fcc1ff68b5837a90a3489194c4f2821b804c98bbb14b5b97336a2580493cb723</originalsourceid><addsrcrecordid>eNp9kUFLHTEUhUNR6qv2D3QhA65jc5PMTLIU0bYgFEQXrkKSuXlG3kyeyQy0_77RZysFMVnkcvOdmxMOIV-AnQJj_dfCGAdBGWjKWikk7T6QFUjBKWc93yMrxoSgAlp1QD6V8sDqkkp-JAcCdO12bEXurnFYPA5NxrJNU8EmTvfRxTmmqbFhxtzgr20qS8ZmTs2QlzXNuLFzlfgFS8Wb0W6wucecam1dmW2cMJcjsh_spuDnl_OQ3F5e3Jx_p1c_v_04P7uiXko-UwjeQwidcq0SvdXMCqk0aOll4IqDU0x6rZxzIF3rdC9EZ3lbu1p413NxSE52c7c5PVZHs3lIS57qk4YL1fK25Zy9Uutq1sQppDlbP8bizVkHmkuQAJU6fYOqe8Ax-jRhiLX_n4DvBD6nUjIGs81xtPm3AWaeQjK7kEwNyTyHZLoqOn5xvLgRh3-Sv6lUQOyAUq-mNebXL70z9g8cbJpx</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2385255220</pqid></control><display><type>article</type><title>Reduced response inhibition after exposure to drug-related cues in male heroin abstainers</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Su, Bobo ; Li, Shaomei ; Yang, Ling ; Zheng, Meihong</creator><creatorcontrib>Su, Bobo ; Li, Shaomei ; Yang, Ling ; Zheng, Meihong</creatorcontrib><description>Rationale
Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibition in heroin users following abstinence.
Objectives
The present study aimed to investigate how drug-related cues with different durations between stimulus presentations, referred to as stimulus onset asynchronies (SOAs), affect subsequent response inhibition in heroin abstainers (HAs) with different length of abstinence.
Methods
Sixty-seven male HAs performed a modified Go/NoGo task in which a motor response to frequent Go targets and no response to rare NoGo targets were required and a Go or NoGo target was displayed after either a heroin-related or a neutral picture presented for the 200 ms and 600 ms SOAs.
Results
The HAs responded significantly faster to Go targets following the neutral pictures for the 600 ms SOA compared to other conditions. They also made more commission errors following heroin-related pictures compared to neutral pictures regardless of the SOAs. The shorter-term HAs made more commission errors compared to the longer-term HAs following the 200 ms SOA, and it was only a trend when the SOA was 600 ms. Additionally, negative correlations between the duration of current abstinence and commission errors were observed following cues with the 200 ms SOA.
Conclusions
Impaired response inhibition in HAs can be improved through protracted drug abstinence. However, that effect can be reduced by exposure to drug-related cues, which may increase the risk of relapse.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-019-05434-6</identifier><identifier>PMID: 31915860</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Analysis ; Behavioral assessment ; Biomedical and Life Sciences ; Biomedicine ; Cues ; Drug abuse ; Go/no-go discrimination learning ; Heroin ; Heroin - administration & dosage ; Heroin - adverse effects ; Heroin Dependence - diagnosis ; Heroin Dependence - psychology ; Humans ; Inhibition, Psychological ; Male ; Methods ; Middle Aged ; Neurosciences ; Original Investigation ; Pharmacology/Toxicology ; Photic Stimulation - methods ; Psychiatry ; Psychological aspects ; Reaction Time - drug effects ; Reaction Time - physiology ; Set (Psychology) ; Time Factors</subject><ispartof>Psychopharmacology, 2020-04, Vol.237 (4), p.1055-1062</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-1fcc1ff68b5837a90a3489194c4f2821b804c98bbb14b5b97336a2580493cb723</citedby><cites>FETCH-LOGICAL-c442t-1fcc1ff68b5837a90a3489194c4f2821b804c98bbb14b5b97336a2580493cb723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-019-05434-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-019-05434-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31915860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Bobo</creatorcontrib><creatorcontrib>Li, Shaomei</creatorcontrib><creatorcontrib>Yang, Ling</creatorcontrib><creatorcontrib>Zheng, Meihong</creatorcontrib><title>Reduced response inhibition after exposure to drug-related cues in male heroin abstainers</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibition in heroin users following abstinence.
Objectives
The present study aimed to investigate how drug-related cues with different durations between stimulus presentations, referred to as stimulus onset asynchronies (SOAs), affect subsequent response inhibition in heroin abstainers (HAs) with different length of abstinence.
Methods
Sixty-seven male HAs performed a modified Go/NoGo task in which a motor response to frequent Go targets and no response to rare NoGo targets were required and a Go or NoGo target was displayed after either a heroin-related or a neutral picture presented for the 200 ms and 600 ms SOAs.
Results
The HAs responded significantly faster to Go targets following the neutral pictures for the 600 ms SOA compared to other conditions. They also made more commission errors following heroin-related pictures compared to neutral pictures regardless of the SOAs. The shorter-term HAs made more commission errors compared to the longer-term HAs following the 200 ms SOA, and it was only a trend when the SOA was 600 ms. Additionally, negative correlations between the duration of current abstinence and commission errors were observed following cues with the 200 ms SOA.
Conclusions
Impaired response inhibition in HAs can be improved through protracted drug abstinence. However, that effect can be reduced by exposure to drug-related cues, which may increase the risk of relapse.</description><subject>Adult</subject><subject>Analysis</subject><subject>Behavioral assessment</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cues</subject><subject>Drug abuse</subject><subject>Go/no-go discrimination learning</subject><subject>Heroin</subject><subject>Heroin - administration & dosage</subject><subject>Heroin - adverse effects</subject><subject>Heroin Dependence - diagnosis</subject><subject>Heroin Dependence - psychology</subject><subject>Humans</subject><subject>Inhibition, Psychological</subject><subject>Male</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Original Investigation</subject><subject>Pharmacology/Toxicology</subject><subject>Photic Stimulation - methods</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Set (Psychology)</subject><subject>Time Factors</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUFLHTEUhUNR6qv2D3QhA65jc5PMTLIU0bYgFEQXrkKSuXlG3kyeyQy0_77RZysFMVnkcvOdmxMOIV-AnQJj_dfCGAdBGWjKWikk7T6QFUjBKWc93yMrxoSgAlp1QD6V8sDqkkp-JAcCdO12bEXurnFYPA5NxrJNU8EmTvfRxTmmqbFhxtzgr20qS8ZmTs2QlzXNuLFzlfgFS8Wb0W6wucecam1dmW2cMJcjsh_spuDnl_OQ3F5e3Jx_p1c_v_04P7uiXko-UwjeQwidcq0SvdXMCqk0aOll4IqDU0x6rZxzIF3rdC9EZ3lbu1p413NxSE52c7c5PVZHs3lIS57qk4YL1fK25Zy9Uutq1sQppDlbP8bizVkHmkuQAJU6fYOqe8Ax-jRhiLX_n4DvBD6nUjIGs81xtPm3AWaeQjK7kEwNyTyHZLoqOn5xvLgRh3-Sv6lUQOyAUq-mNebXL70z9g8cbJpx</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Su, Bobo</creator><creator>Li, Shaomei</creator><creator>Yang, Ling</creator><creator>Zheng, Meihong</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20200401</creationdate><title>Reduced response inhibition after exposure to drug-related cues in male heroin abstainers</title><author>Su, Bobo ; Li, Shaomei ; Yang, Ling ; Zheng, Meihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-1fcc1ff68b5837a90a3489194c4f2821b804c98bbb14b5b97336a2580493cb723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Behavioral assessment</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cues</topic><topic>Drug abuse</topic><topic>Go/no-go discrimination learning</topic><topic>Heroin</topic><topic>Heroin - administration & dosage</topic><topic>Heroin - adverse effects</topic><topic>Heroin Dependence - diagnosis</topic><topic>Heroin Dependence - psychology</topic><topic>Humans</topic><topic>Inhibition, Psychological</topic><topic>Male</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Neurosciences</topic><topic>Original Investigation</topic><topic>Pharmacology/Toxicology</topic><topic>Photic Stimulation - methods</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - physiology</topic><topic>Set (Psychology)</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Bobo</creatorcontrib><creatorcontrib>Li, Shaomei</creatorcontrib><creatorcontrib>Yang, Ling</creatorcontrib><creatorcontrib>Zheng, Meihong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Bobo</au><au>Li, Shaomei</au><au>Yang, Ling</au><au>Zheng, Meihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced response inhibition after exposure to drug-related cues in male heroin abstainers</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>237</volume><issue>4</issue><spage>1055</spage><epage>1062</epage><pages>1055-1062</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
Deficits in response inhibition associated with heroin use could last several months after abstinence in heroin users, and their response inhibition can also be interfered with task-irrelevant drug-related cues. However, it is unclear whether exposure to drug-related cues affects subsequent response inhibition in heroin users following abstinence.
Objectives
The present study aimed to investigate how drug-related cues with different durations between stimulus presentations, referred to as stimulus onset asynchronies (SOAs), affect subsequent response inhibition in heroin abstainers (HAs) with different length of abstinence.
Methods
Sixty-seven male HAs performed a modified Go/NoGo task in which a motor response to frequent Go targets and no response to rare NoGo targets were required and a Go or NoGo target was displayed after either a heroin-related or a neutral picture presented for the 200 ms and 600 ms SOAs.
Results
The HAs responded significantly faster to Go targets following the neutral pictures for the 600 ms SOA compared to other conditions. They also made more commission errors following heroin-related pictures compared to neutral pictures regardless of the SOAs. The shorter-term HAs made more commission errors compared to the longer-term HAs following the 200 ms SOA, and it was only a trend when the SOA was 600 ms. Additionally, negative correlations between the duration of current abstinence and commission errors were observed following cues with the 200 ms SOA.
Conclusions
Impaired response inhibition in HAs can be improved through protracted drug abstinence. However, that effect can be reduced by exposure to drug-related cues, which may increase the risk of relapse.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31915860</pmid><doi>10.1007/s00213-019-05434-6</doi><tpages>8</tpages></addata></record> |
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| issn | 0033-3158 1432-2072 |
| language | eng |
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| subjects | Adult Analysis Behavioral assessment Biomedical and Life Sciences Biomedicine Cues Drug abuse Go/no-go discrimination learning Heroin Heroin - administration & dosage Heroin - adverse effects Heroin Dependence - diagnosis Heroin Dependence - psychology Humans Inhibition, Psychological Male Methods Middle Aged Neurosciences Original Investigation Pharmacology/Toxicology Photic Stimulation - methods Psychiatry Psychological aspects Reaction Time - drug effects Reaction Time - physiology Set (Psychology) Time Factors |
| title | Reduced response inhibition after exposure to drug-related cues in male heroin abstainers |
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