Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice
Nutritional therapy is a cornerstone of burns management. The optimal macronutrient intake for wound healing after burn injury has not been identified, although high-energy, high-protein diets are favoured. The present study aimed to identify the optimal macronutrient intake for burn wound healing....
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| Veröffentlicht in: | British journal of nutrition 2020-05, Vol.123 (9), p.1056-1067 |
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| creator | Hew, Jonathan J Parungao, Roxanne J Tsai, Kevin H-Y Shi, Huaikai Ma, Duncan Nicholls, Caroline Li, Zhe Solon-Biet, Samantha M D'Souza, Mario Le Couteur, David G Simpson, Stephen J Jeschke, Marc G Maitz, Peter K Wang, Yiwei |
| description | Nutritional therapy is a cornerstone of burns management. The optimal macronutrient intake for wound healing after burn injury has not been identified, although high-energy, high-protein diets are favoured. The present study aimed to identify the optimal macronutrient intake for burn wound healing. The geometric framework (GF) was used to analyse wound healing after a 10 % total body surface area contact burn in mice ad libitum fed one of the eleven high-energy diets, varying in macronutrient composition with protein (P5-60 %), carbohydrate (C20-75 %) and fat (F20-75 %). In the GF study, the optimal ratio for wound healing was identified as a moderate-protein, high-carbohydrate diet with a protein:carbohydrate:fat (P:C:F) ratio of 1:4:2. High carbohydrate intake was associated with lower mortality, improved body weight and a beneficial pattern of body fat reserves. Protein intake was essential to prevent weight loss and mortality, but a protein intake target of about 7 kJ/d (about 15 % of energy intake) was identified, above which no further benefit was gained. High protein intake was associated with delayed wound healing and increased liver and spleen weight. As the GF study demonstrated that an initial very high protein intake prevented mortality, a very high-protein, moderate-carbohydrate diet (P40:C42:F18) was specifically designed. The dynamic diet study was also designed to combine and validate the benefits of an initial very high protein intake for mortality, and subsequent moderate protein, high carbohydrate intake for optimal wound healing. The dynamic feeding experiment showed switching from an initial very high-protein diet to the optimal moderate-protein, high-carbohydrate diet accelerated wound healing whilst preventing mortality and liver enlargement. |
| doi_str_mv | 10.1017/S0007114520000276 |
| format | Article |
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The optimal macronutrient intake for wound healing after burn injury has not been identified, although high-energy, high-protein diets are favoured. The present study aimed to identify the optimal macronutrient intake for burn wound healing. The geometric framework (GF) was used to analyse wound healing after a 10 % total body surface area contact burn in mice ad libitum fed one of the eleven high-energy diets, varying in macronutrient composition with protein (P5-60 %), carbohydrate (C20-75 %) and fat (F20-75 %). In the GF study, the optimal ratio for wound healing was identified as a moderate-protein, high-carbohydrate diet with a protein:carbohydrate:fat (P:C:F) ratio of 1:4:2. High carbohydrate intake was associated with lower mortality, improved body weight and a beneficial pattern of body fat reserves. Protein intake was essential to prevent weight loss and mortality, but a protein intake target of about 7 kJ/d (about 15 % of energy intake) was identified, above which no further benefit was gained. High protein intake was associated with delayed wound healing and increased liver and spleen weight. As the GF study demonstrated that an initial very high protein intake prevented mortality, a very high-protein, moderate-carbohydrate diet (P40:C42:F18) was specifically designed. The dynamic diet study was also designed to combine and validate the benefits of an initial very high protein intake for mortality, and subsequent moderate protein, high carbohydrate intake for optimal wound healing. The dynamic feeding experiment showed switching from an initial very high-protein diet to the optimal moderate-protein, high-carbohydrate diet accelerated wound healing whilst preventing mortality and liver enlargement.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114520000276</identifier><identifier>PMID: 31983360</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Animal Nutritional Physiological Phenomena ; Animals ; Body fat ; Body weight ; Body weight loss ; Burns ; Burns - diet therapy ; Carbohydrates ; Diet ; Dietary Carbohydrates - administration & dosage ; Dietary Fats - administration & dosage ; Dietary Proteins - administration & dosage ; Energy ; Energy Intake ; Enlargement ; High carbohydrate diet ; High protein diet ; Liver ; Male ; Mice ; Models, Biological ; Mortality ; Nutrition research ; Nutrition therapy ; Protein composition ; Proteins ; Spleen ; Sucrose ; Trauma ; Weight loss ; Wound healing</subject><ispartof>British journal of nutrition, 2020-05, Vol.123 (9), p.1056-1067</ispartof><rights>Copyright Cambridge University Press May 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-1169d6fdc8f7d065eb0d0160c848b9690e38f37e014cf1f021e88be3d3e079f93</citedby><cites>FETCH-LOGICAL-c329t-1169d6fdc8f7d065eb0d0160c848b9690e38f37e014cf1f021e88be3d3e079f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31983360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hew, Jonathan J</creatorcontrib><creatorcontrib>Parungao, Roxanne J</creatorcontrib><creatorcontrib>Tsai, Kevin H-Y</creatorcontrib><creatorcontrib>Shi, Huaikai</creatorcontrib><creatorcontrib>Ma, Duncan</creatorcontrib><creatorcontrib>Nicholls, Caroline</creatorcontrib><creatorcontrib>Li, Zhe</creatorcontrib><creatorcontrib>Solon-Biet, Samantha M</creatorcontrib><creatorcontrib>D'Souza, Mario</creatorcontrib><creatorcontrib>Le Couteur, David G</creatorcontrib><creatorcontrib>Simpson, Stephen J</creatorcontrib><creatorcontrib>Jeschke, Marc G</creatorcontrib><creatorcontrib>Maitz, Peter K</creatorcontrib><creatorcontrib>Wang, Yiwei</creatorcontrib><title>Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Nutritional therapy is a cornerstone of burns management. The optimal macronutrient intake for wound healing after burn injury has not been identified, although high-energy, high-protein diets are favoured. The present study aimed to identify the optimal macronutrient intake for burn wound healing. The geometric framework (GF) was used to analyse wound healing after a 10 % total body surface area contact burn in mice ad libitum fed one of the eleven high-energy diets, varying in macronutrient composition with protein (P5-60 %), carbohydrate (C20-75 %) and fat (F20-75 %). In the GF study, the optimal ratio for wound healing was identified as a moderate-protein, high-carbohydrate diet with a protein:carbohydrate:fat (P:C:F) ratio of 1:4:2. High carbohydrate intake was associated with lower mortality, improved body weight and a beneficial pattern of body fat reserves. Protein intake was essential to prevent weight loss and mortality, but a protein intake target of about 7 kJ/d (about 15 % of energy intake) was identified, above which no further benefit was gained. High protein intake was associated with delayed wound healing and increased liver and spleen weight. As the GF study demonstrated that an initial very high protein intake prevented mortality, a very high-protein, moderate-carbohydrate diet (P40:C42:F18) was specifically designed. The dynamic diet study was also designed to combine and validate the benefits of an initial very high protein intake for mortality, and subsequent moderate protein, high carbohydrate intake for optimal wound healing. The dynamic feeding experiment showed switching from an initial very high-protein diet to the optimal moderate-protein, high-carbohydrate diet accelerated wound healing whilst preventing mortality and liver enlargement.</description><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Body fat</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Burns</subject><subject>Burns - diet therapy</subject><subject>Carbohydrates</subject><subject>Diet</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Energy</subject><subject>Energy Intake</subject><subject>Enlargement</subject><subject>High carbohydrate diet</subject><subject>High protein diet</subject><subject>Liver</subject><subject>Male</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Mortality</subject><subject>Nutrition research</subject><subject>Nutrition therapy</subject><subject>Protein composition</subject><subject>Proteins</subject><subject>Spleen</subject><subject>Sucrose</subject><subject>Trauma</subject><subject>Weight loss</subject><subject>Wound 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Edition</collection><collection>ProQuest Central Basic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hew, Jonathan J</au><au>Parungao, Roxanne J</au><au>Tsai, Kevin H-Y</au><au>Shi, Huaikai</au><au>Ma, Duncan</au><au>Nicholls, Caroline</au><au>Li, Zhe</au><au>Solon-Biet, Samantha M</au><au>D'Souza, Mario</au><au>Le Couteur, David G</au><au>Simpson, Stephen J</au><au>Jeschke, Marc G</au><au>Maitz, Peter K</au><au>Wang, Yiwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2020-05-14</date><risdate>2020</risdate><volume>123</volume><issue>9</issue><spage>1056</spage><epage>1067</epage><pages>1056-1067</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>Nutritional therapy is a cornerstone of burns management. The optimal macronutrient intake for wound healing after burn injury has not been identified, although high-energy, high-protein diets are favoured. The present study aimed to identify the optimal macronutrient intake for burn wound healing. The geometric framework (GF) was used to analyse wound healing after a 10 % total body surface area contact burn in mice ad libitum fed one of the eleven high-energy diets, varying in macronutrient composition with protein (P5-60 %), carbohydrate (C20-75 %) and fat (F20-75 %). In the GF study, the optimal ratio for wound healing was identified as a moderate-protein, high-carbohydrate diet with a protein:carbohydrate:fat (P:C:F) ratio of 1:4:2. High carbohydrate intake was associated with lower mortality, improved body weight and a beneficial pattern of body fat reserves. Protein intake was essential to prevent weight loss and mortality, but a protein intake target of about 7 kJ/d (about 15 % of energy intake) was identified, above which no further benefit was gained. High protein intake was associated with delayed wound healing and increased liver and spleen weight. As the GF study demonstrated that an initial very high protein intake prevented mortality, a very high-protein, moderate-carbohydrate diet (P40:C42:F18) was specifically designed. The dynamic diet study was also designed to combine and validate the benefits of an initial very high protein intake for mortality, and subsequent moderate protein, high carbohydrate intake for optimal wound healing. The dynamic feeding experiment showed switching from an initial very high-protein diet to the optimal moderate-protein, high-carbohydrate diet accelerated wound healing whilst preventing mortality and liver enlargement.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>31983360</pmid><doi>10.1017/S0007114520000276</doi><tpages>12</tpages></addata></record> |
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| subjects | Animal Nutritional Physiological Phenomena Animals Body fat Body weight Body weight loss Burns Burns - diet therapy Carbohydrates Diet Dietary Carbohydrates - administration & dosage Dietary Fats - administration & dosage Dietary Proteins - administration & dosage Energy Energy Intake Enlargement High carbohydrate diet High protein diet Liver Male Mice Models, Biological Mortality Nutrition research Nutrition therapy Protein composition Proteins Spleen Sucrose Trauma Weight loss Wound healing |
| title | Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice |
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