Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats
Arsenic (As) can contaminate air, soil, water, and organisms through mobilization of natural mineralogical deposits or anthropogenic actions. Inorganic‐As compounds are more toxic and widely available in aquatic environments, including drinking water reservoir catchments. Since little is known about...
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| Veröffentlicht in: | Environmental toxicology 2020-05, Vol.35 (5), p.553-560 |
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| creator | Samelo, Ricardo R. Cunha de Medeiros, Paloma Carvalho Cavalcante, Deborah N. Aranha, Maria L. G. Duarte, Fabio A. Castro, Ítalo B. Ribeiro, Daniel A. Perobelli, Juliana E. |
| description | Arsenic (As) can contaminate air, soil, water, and organisms through mobilization of natural mineralogical deposits or anthropogenic actions. Inorganic‐As compounds are more toxic and widely available in aquatic environments, including drinking water reservoir catchments. Since little is known about its effects on prepubertal mammals, the present study focused on it. Hence, As was administered through drinking water to male Wistar rats from postnatal day 23 to 53. Negative control group received vehicle only (filtered water); As 1 group received AsNaO2 at 0.01 mg L−1 and As2 group received AsNaO2 at 10 mg L−1. It was investigated hepatic and renal toxicity of AsNaO2 (ie, histopathology and apoptosis analysis), as well as its mutagenicity (ie, micronucleus test in liver and bone marrow), cytotoxicity (ie, frequency and type of erythrocytes in blood), and genotoxicity (ie, comet assay in blood). Also, As determination was performed in hepatic and renal tissues. Data obtained revealed that immature organisms present a pattern of arsenic accumulation similar to that observed in adults, suggesting similarity in metabolic processes. In addition, liver showed to be an important target tissue for As toxicity in these experimental conditions, exhibiting infiltrate of defense cells, DNA damages, and increased apoptosis rates. |
| doi_str_mv | 10.1002/tox.22890 |
| format | Article |
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G. ; Duarte, Fabio A. ; Castro, Ítalo B. ; Ribeiro, Daniel A. ; Perobelli, Juliana E.</creator><creatorcontrib>Samelo, Ricardo R. ; Cunha de Medeiros, Paloma ; Carvalho Cavalcante, Deborah N. ; Aranha, Maria L. G. ; Duarte, Fabio A. ; Castro, Ítalo B. ; Ribeiro, Daniel A. ; Perobelli, Juliana E.</creatorcontrib><description>Arsenic (As) can contaminate air, soil, water, and organisms through mobilization of natural mineralogical deposits or anthropogenic actions. Inorganic‐As compounds are more toxic and widely available in aquatic environments, including drinking water reservoir catchments. Since little is known about its effects on prepubertal mammals, the present study focused on it. Hence, As was administered through drinking water to male Wistar rats from postnatal day 23 to 53. Negative control group received vehicle only (filtered water); As 1 group received AsNaO2 at 0.01 mg L−1 and As2 group received AsNaO2 at 10 mg L−1. It was investigated hepatic and renal toxicity of AsNaO2 (ie, histopathology and apoptosis analysis), as well as its mutagenicity (ie, micronucleus test in liver and bone marrow), cytotoxicity (ie, frequency and type of erythrocytes in blood), and genotoxicity (ie, comet assay in blood). Also, As determination was performed in hepatic and renal tissues. Data obtained revealed that immature organisms present a pattern of arsenic accumulation similar to that observed in adults, suggesting similarity in metabolic processes. In addition, liver showed to be an important target tissue for As toxicity in these experimental conditions, exhibiting infiltrate of defense cells, DNA damages, and increased apoptosis rates.</description><identifier>ISSN: 1520-4081</identifier><identifier>EISSN: 1522-7278</identifier><identifier>DOI: 10.1002/tox.22890</identifier><identifier>PMID: 31846182</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Air pollution ; Anthropogenic factors ; Apoptosis ; Aquatic environment ; Arsenic ; Arsenite ; Bioassays ; Blood ; Bone marrow ; Catchment area ; Catchments ; Comet assay ; Cytotoxicity ; Damage detection ; DNA ; DNA damage ; Drinking behavior ; Drinking water ; Erythrocytes ; Genotoxicity ; Hepatotoxicity ; Histopathology ; kidneys ; Liver ; Low concentrations ; Males ; Mutagenicity ; rats ; Rodents ; Sodium ; Sodium arsenite ; Soil ; Soil contamination ; Soil pollution ; Soil water ; Tissue ; Toxicity ; Toxicity tests ; Water purification ; Water reservoirs</subject><ispartof>Environmental toxicology, 2020-05, Vol.35 (5), p.553-560</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3900-23efe1e141d126b4a7e6cff24526826c0c19192d56b9b5832b99ba084cd9dba43</citedby><cites>FETCH-LOGICAL-c3900-23efe1e141d126b4a7e6cff24526826c0c19192d56b9b5832b99ba084cd9dba43</cites><orcidid>0000-0002-6797-2117</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftox.22890$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftox.22890$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31846182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samelo, Ricardo R.</creatorcontrib><creatorcontrib>Cunha de Medeiros, Paloma</creatorcontrib><creatorcontrib>Carvalho Cavalcante, Deborah N.</creatorcontrib><creatorcontrib>Aranha, Maria L. G.</creatorcontrib><creatorcontrib>Duarte, Fabio A.</creatorcontrib><creatorcontrib>Castro, Ítalo B.</creatorcontrib><creatorcontrib>Ribeiro, Daniel A.</creatorcontrib><creatorcontrib>Perobelli, Juliana E.</creatorcontrib><title>Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats</title><title>Environmental toxicology</title><addtitle>Environ Toxicol</addtitle><description>Arsenic (As) can contaminate air, soil, water, and organisms through mobilization of natural mineralogical deposits or anthropogenic actions. Inorganic‐As compounds are more toxic and widely available in aquatic environments, including drinking water reservoir catchments. Since little is known about its effects on prepubertal mammals, the present study focused on it. Hence, As was administered through drinking water to male Wistar rats from postnatal day 23 to 53. Negative control group received vehicle only (filtered water); As 1 group received AsNaO2 at 0.01 mg L−1 and As2 group received AsNaO2 at 10 mg L−1. It was investigated hepatic and renal toxicity of AsNaO2 (ie, histopathology and apoptosis analysis), as well as its mutagenicity (ie, micronucleus test in liver and bone marrow), cytotoxicity (ie, frequency and type of erythrocytes in blood), and genotoxicity (ie, comet assay in blood). Also, As determination was performed in hepatic and renal tissues. Data obtained revealed that immature organisms present a pattern of arsenic accumulation similar to that observed in adults, suggesting similarity in metabolic processes. In addition, liver showed to be an important target tissue for As toxicity in these experimental conditions, exhibiting infiltrate of defense cells, DNA damages, and increased apoptosis rates.</description><subject>Air pollution</subject><subject>Anthropogenic factors</subject><subject>Apoptosis</subject><subject>Aquatic environment</subject><subject>Arsenic</subject><subject>Arsenite</subject><subject>Bioassays</subject><subject>Blood</subject><subject>Bone marrow</subject><subject>Catchment area</subject><subject>Catchments</subject><subject>Comet assay</subject><subject>Cytotoxicity</subject><subject>Damage detection</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Drinking behavior</subject><subject>Drinking water</subject><subject>Erythrocytes</subject><subject>Genotoxicity</subject><subject>Hepatotoxicity</subject><subject>Histopathology</subject><subject>kidneys</subject><subject>Liver</subject><subject>Low concentrations</subject><subject>Males</subject><subject>Mutagenicity</subject><subject>rats</subject><subject>Rodents</subject><subject>Sodium</subject><subject>Sodium arsenite</subject><subject>Soil</subject><subject>Soil contamination</subject><subject>Soil pollution</subject><subject>Soil water</subject><subject>Tissue</subject><subject>Toxicity</subject><subject>Toxicity tests</subject><subject>Water purification</subject><subject>Water reservoirs</subject><issn>1520-4081</issn><issn>1522-7278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQhoMotlYP_gEJePKwbZL9aHKU4hcUeqngLSTZWUzZ3azJLrX_3thVb55mGB6el3kRuqZkTglhi959zhnjgpygKc0ZS5ZsyU-PO0kywukEXYSwI4SIIi_O0SSlPCsoZ1O0Xbs9Nq410PZe9da1AbsKB1faocHKB2htD9i25WAAv0OnehfjrLH9IV5x56EbNPhe1bhRNeAoCZforFJ1gKufOUOvjw_b1XOy3jy9rO7XiUkFIQlLoQIKNKMlZYXO1BIKU1Usy1nBWWGIoYIKVuaFFjrnKdNCaEV4ZkpRapWlM3Q7ejvvPgYIvdy5wbcxUrKU57GbNBORuhsp410IHirZedsof5CUyO_-ZHxIHvuL7M2PcdANlH_kb2ERWIzA3tZw-N8kt5u3UfkFQy96qQ</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Samelo, Ricardo R.</creator><creator>Cunha de Medeiros, Paloma</creator><creator>Carvalho Cavalcante, Deborah N.</creator><creator>Aranha, Maria L. 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G. ; Duarte, Fabio A. ; Castro, Ítalo B. ; Ribeiro, Daniel A. ; Perobelli, Juliana E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3900-23efe1e141d126b4a7e6cff24526826c0c19192d56b9b5832b99ba084cd9dba43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Air pollution</topic><topic>Anthropogenic factors</topic><topic>Apoptosis</topic><topic>Aquatic environment</topic><topic>Arsenic</topic><topic>Arsenite</topic><topic>Bioassays</topic><topic>Blood</topic><topic>Bone marrow</topic><topic>Catchment area</topic><topic>Catchments</topic><topic>Comet assay</topic><topic>Cytotoxicity</topic><topic>Damage detection</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Drinking behavior</topic><topic>Drinking water</topic><topic>Erythrocytes</topic><topic>Genotoxicity</topic><topic>Hepatotoxicity</topic><topic>Histopathology</topic><topic>kidneys</topic><topic>Liver</topic><topic>Low concentrations</topic><topic>Males</topic><topic>Mutagenicity</topic><topic>rats</topic><topic>Rodents</topic><topic>Sodium</topic><topic>Sodium arsenite</topic><topic>Soil</topic><topic>Soil contamination</topic><topic>Soil pollution</topic><topic>Soil water</topic><topic>Tissue</topic><topic>Toxicity</topic><topic>Toxicity tests</topic><topic>Water purification</topic><topic>Water reservoirs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samelo, Ricardo R.</creatorcontrib><creatorcontrib>Cunha de Medeiros, Paloma</creatorcontrib><creatorcontrib>Carvalho Cavalcante, Deborah N.</creatorcontrib><creatorcontrib>Aranha, Maria L. G.</creatorcontrib><creatorcontrib>Duarte, Fabio A.</creatorcontrib><creatorcontrib>Castro, Ítalo B.</creatorcontrib><creatorcontrib>Ribeiro, Daniel A.</creatorcontrib><creatorcontrib>Perobelli, Juliana E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samelo, Ricardo R.</au><au>Cunha de Medeiros, Paloma</au><au>Carvalho Cavalcante, Deborah N.</au><au>Aranha, Maria L. G.</au><au>Duarte, Fabio A.</au><au>Castro, Ítalo B.</au><au>Ribeiro, Daniel A.</au><au>Perobelli, Juliana E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats</atitle><jtitle>Environmental toxicology</jtitle><addtitle>Environ Toxicol</addtitle><date>2020-05</date><risdate>2020</risdate><volume>35</volume><issue>5</issue><spage>553</spage><epage>560</epage><pages>553-560</pages><issn>1520-4081</issn><eissn>1522-7278</eissn><abstract>Arsenic (As) can contaminate air, soil, water, and organisms through mobilization of natural mineralogical deposits or anthropogenic actions. Inorganic‐As compounds are more toxic and widely available in aquatic environments, including drinking water reservoir catchments. Since little is known about its effects on prepubertal mammals, the present study focused on it. Hence, As was administered through drinking water to male Wistar rats from postnatal day 23 to 53. Negative control group received vehicle only (filtered water); As 1 group received AsNaO2 at 0.01 mg L−1 and As2 group received AsNaO2 at 10 mg L−1. It was investigated hepatic and renal toxicity of AsNaO2 (ie, histopathology and apoptosis analysis), as well as its mutagenicity (ie, micronucleus test in liver and bone marrow), cytotoxicity (ie, frequency and type of erythrocytes in blood), and genotoxicity (ie, comet assay in blood). Also, As determination was performed in hepatic and renal tissues. Data obtained revealed that immature organisms present a pattern of arsenic accumulation similar to that observed in adults, suggesting similarity in metabolic processes. In addition, liver showed to be an important target tissue for As toxicity in these experimental conditions, exhibiting infiltrate of defense cells, DNA damages, and increased apoptosis rates.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31846182</pmid><doi>10.1002/tox.22890</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6797-2117</orcidid></addata></record> |
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| subjects | Air pollution Anthropogenic factors Apoptosis Aquatic environment Arsenic Arsenite Bioassays Blood Bone marrow Catchment area Catchments Comet assay Cytotoxicity Damage detection DNA DNA damage Drinking behavior Drinking water Erythrocytes Genotoxicity Hepatotoxicity Histopathology kidneys Liver Low concentrations Males Mutagenicity rats Rodents Sodium Sodium arsenite Soil Soil contamination Soil pollution Soil water Tissue Toxicity Toxicity tests Water purification Water reservoirs |
| title | Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats |
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