Radiation Therapy Reduced Blood Levels of LDH, HIF-1α, and miR-210 in OSCC
Radiation Therapy (RT) is a treatment option for a large number of neoplasias. However, the effect of RT on the level of hypoxia markers is poorly understood. The present study aimed to investigate the effect of RT on the levels of hypoxic markers in Oral squamous cell carcinoma (OSCC). Evaluation o...
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| Veröffentlicht in: | Pathology oncology research 2020-01, Vol.26 (1), p.433-442 |
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| creator | de Souza, Marcela Gonçalves de Jesus, Sabrina Ferreira Santos, Eloá Mangabeira Gomes, Emisael Stenio Batista de Paulo Santiago Filho, Arlen Santos, Eliane Macedo Sobrinho da Silveira, Luiz Henrique Santos, Sérgio Henrique Sousa de Paula, Alfredo Maurício Batista Farias, Lucyana Conceição Guimarães, André Luiz Sena |
| description | Radiation Therapy (RT) is a treatment option for a large number of neoplasias. However, the effect of RT on the level of hypoxia markers is poorly understood. The present study aimed to investigate the effect of RT on the levels of hypoxic markers in Oral squamous cell carcinoma (OSCC). Evaluation of HIF-1α and miR-210 levels in OSCC was performed. Then a proteomic analysis was performed to identify candidate hypoxic targets of RT. To validate proteomic studies, the effect of RT on HIF-1α, miR-210, PDH-A and LDH-A levels under hypoxia was assessed by qRT-PCR. The impact of RT in hypoxia markers was evaluated in patients to confirm in vitro results. An increase in the HIF-1α levels was observed in OSCC. RT reduced OSCC cell proliferation and migration. Interestingly, hypoxia could revert the effect of radiation on OSCC phenotype. However, proteomics analyses suggested that LDH is one of the critical targets of RT even in hypoxia. Moreover, RT decreased HIF-1α, miR-210, and LDH even in hypoxia. The current study demonstrated that hypoxia could revert the effects of RT in the OSCC context. However, RT reduces the levels HIF-1α, miR-210 and LDH in vivo and in vitro. The consequences of RT in blood should be carefully investigated. |
| doi_str_mv | 10.1007/s12253-018-0517-2 |
| format | Article |
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However, the effect of RT on the level of hypoxia markers is poorly understood. The present study aimed to investigate the effect of RT on the levels of hypoxic markers in Oral squamous cell carcinoma (OSCC). Evaluation of HIF-1α and miR-210 levels in OSCC was performed. Then a proteomic analysis was performed to identify candidate hypoxic targets of RT. To validate proteomic studies, the effect of RT on HIF-1α, miR-210, PDH-A and LDH-A levels under hypoxia was assessed by qRT-PCR. The impact of RT in hypoxia markers was evaluated in patients to confirm in vitro results. An increase in the HIF-1α levels was observed in OSCC. RT reduced OSCC cell proliferation and migration. Interestingly, hypoxia could revert the effect of radiation on OSCC phenotype. However, proteomics analyses suggested that LDH is one of the critical targets of RT even in hypoxia. Moreover, RT decreased HIF-1α, miR-210, and LDH even in hypoxia. The current study demonstrated that hypoxia could revert the effects of RT in the OSCC context. However, RT reduces the levels HIF-1α, miR-210 and LDH in vivo and in vitro. The consequences of RT in blood should be carefully investigated.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-018-0517-2</identifier><identifier>PMID: 30406875</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Blood levels ; Cancer Research ; Cell Hypoxia - radiation effects ; Cell migration ; Cell proliferation ; Female ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit - blood ; Hypoxia-Inducible Factor 1, alpha Subunit - radiation effects ; Immunology ; L-Lactate Dehydrogenase - blood ; L-Lactate Dehydrogenase - radiation effects ; Male ; MicroRNAs - blood ; MicroRNAs - radiation effects ; Middle Aged ; Migration ; Oncology ; Oral cancer ; Oral squamous cell carcinoma ; Original Article ; Pathology ; Phenotypes ; Proteomics ; Radiation ; Radiation therapy ; Radiation Tolerance ; Radiotherapy - adverse effects ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - radiotherapy ; Young Adult</subject><ispartof>Pathology oncology research, 2020-01, Vol.26 (1), p.433-442</ispartof><rights>Arányi Lajos Foundation 2018</rights><rights>Pathology & Oncology Research is a copyright of Springer, (2018). All Rights Reserved.</rights><rights>2018© Arányi Lajos Foundation 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-3e5acea9fe71504a6c93c67e1bbc432ed3360612e9b6e1909d4dd92f9ec387d83</citedby><cites>FETCH-LOGICAL-c443t-3e5acea9fe71504a6c93c67e1bbc432ed3360612e9b6e1909d4dd92f9ec387d83</cites><orcidid>0000-0002-3162-3206</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-018-0517-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-018-0517-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30406875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Souza, Marcela Gonçalves</creatorcontrib><creatorcontrib>de Jesus, Sabrina Ferreira</creatorcontrib><creatorcontrib>Santos, Eloá Mangabeira</creatorcontrib><creatorcontrib>Gomes, Emisael Stenio Batista</creatorcontrib><creatorcontrib>de Paulo Santiago Filho, Arlen</creatorcontrib><creatorcontrib>Santos, Eliane Macedo Sobrinho</creatorcontrib><creatorcontrib>da Silveira, Luiz Henrique</creatorcontrib><creatorcontrib>Santos, Sérgio Henrique Sousa</creatorcontrib><creatorcontrib>de Paula, Alfredo Maurício Batista</creatorcontrib><creatorcontrib>Farias, Lucyana Conceição</creatorcontrib><creatorcontrib>Guimarães, André Luiz Sena</creatorcontrib><title>Radiation Therapy Reduced Blood Levels of LDH, HIF-1α, and miR-210 in OSCC</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description>Radiation Therapy (RT) is a treatment option for a large number of neoplasias. However, the effect of RT on the level of hypoxia markers is poorly understood. The present study aimed to investigate the effect of RT on the levels of hypoxic markers in Oral squamous cell carcinoma (OSCC). Evaluation of HIF-1α and miR-210 levels in OSCC was performed. Then a proteomic analysis was performed to identify candidate hypoxic targets of RT. To validate proteomic studies, the effect of RT on HIF-1α, miR-210, PDH-A and LDH-A levels under hypoxia was assessed by qRT-PCR. The impact of RT in hypoxia markers was evaluated in patients to confirm in vitro results. An increase in the HIF-1α levels was observed in OSCC. RT reduced OSCC cell proliferation and migration. Interestingly, hypoxia could revert the effect of radiation on OSCC phenotype. However, proteomics analyses suggested that LDH is one of the critical targets of RT even in hypoxia. Moreover, RT decreased HIF-1α, miR-210, and LDH even in hypoxia. The current study demonstrated that hypoxia could revert the effects of RT in the OSCC context. However, RT reduces the levels HIF-1α, miR-210 and LDH in vivo and in vitro. The consequences of RT in blood should be carefully investigated.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood levels</subject><subject>Cancer Research</subject><subject>Cell Hypoxia - radiation effects</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - blood</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - radiation effects</subject><subject>Immunology</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>L-Lactate Dehydrogenase - radiation effects</subject><subject>Male</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - radiation effects</subject><subject>Middle Aged</subject><subject>Migration</subject><subject>Oncology</subject><subject>Oral cancer</subject><subject>Oral squamous cell carcinoma</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Phenotypes</subject><subject>Proteomics</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Radiation Tolerance</subject><subject>Radiotherapy - adverse effects</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck - radiotherapy</subject><subject>Young Adult</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kMtOwzAQRS0E4lH4ADbIEtsaPJ7YiZcQKEVEqlTKOnLjCQS1SYlbJD6LH-GbSFUeK1jNSHPmXukwdgzyDKSMzwMopVFISITUEAu1xfZBoxIqkfF2tyuwIrLa7LGDEJ5l92Os2WV7KCNpkljvs7ux85VbVk3NJ0_UusUbH5NfFeT55axpPM_olWaBNyXProZ9PrwdCPh473NXez6vxkKB5FXNR_dpesh2SjcLdPQ1e-xhcD1JhyIb3dymF5koogiXAkm7gpwtKQYtI2cKi4WJCabTIkJFHtFIA4rs1BBYaX3kvVWlpQKT2CfYY6eb3EXbvKwoLPPnZtXWXWWuMIkSbdHivxQgSIwN6o6CDVW0TQgtlfmireaufctB5mvJ-UZy3knO15K7ih47-UpeTefkfz6-rXaA2gChO9WP1P5W_536CVTLgq4</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>de Souza, Marcela Gonçalves</creator><creator>de Jesus, Sabrina Ferreira</creator><creator>Santos, Eloá Mangabeira</creator><creator>Gomes, Emisael Stenio Batista</creator><creator>de Paulo Santiago Filho, Arlen</creator><creator>Santos, Eliane Macedo Sobrinho</creator><creator>da Silveira, Luiz Henrique</creator><creator>Santos, Sérgio Henrique Sousa</creator><creator>de Paula, Alfredo Maurício Batista</creator><creator>Farias, Lucyana Conceição</creator><creator>Guimarães, André Luiz Sena</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-3162-3206</orcidid></search><sort><creationdate>20200101</creationdate><title>Radiation Therapy Reduced Blood Levels of LDH, HIF-1α, and miR-210 in OSCC</title><author>de Souza, Marcela Gonçalves ; de Jesus, Sabrina Ferreira ; Santos, Eloá Mangabeira ; Gomes, Emisael Stenio Batista ; de Paulo Santiago Filho, Arlen ; Santos, Eliane Macedo Sobrinho ; da Silveira, Luiz Henrique ; Santos, Sérgio Henrique Sousa ; de Paula, Alfredo Maurício Batista ; Farias, Lucyana Conceição ; Guimarães, André Luiz Sena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-3e5acea9fe71504a6c93c67e1bbc432ed3360612e9b6e1909d4dd92f9ec387d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood levels</topic><topic>Cancer Research</topic><topic>Cell Hypoxia - 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Oncol. Res</stitle><addtitle>Pathol Oncol Res</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>26</volume><issue>1</issue><spage>433</spage><epage>442</epage><pages>433-442</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract>Radiation Therapy (RT) is a treatment option for a large number of neoplasias. However, the effect of RT on the level of hypoxia markers is poorly understood. The present study aimed to investigate the effect of RT on the levels of hypoxic markers in Oral squamous cell carcinoma (OSCC). Evaluation of HIF-1α and miR-210 levels in OSCC was performed. Then a proteomic analysis was performed to identify candidate hypoxic targets of RT. To validate proteomic studies, the effect of RT on HIF-1α, miR-210, PDH-A and LDH-A levels under hypoxia was assessed by qRT-PCR. The impact of RT in hypoxia markers was evaluated in patients to confirm in vitro results. An increase in the HIF-1α levels was observed in OSCC. RT reduced OSCC cell proliferation and migration. Interestingly, hypoxia could revert the effect of radiation on OSCC phenotype. However, proteomics analyses suggested that LDH is one of the critical targets of RT even in hypoxia. Moreover, RT decreased HIF-1α, miR-210, and LDH even in hypoxia. The current study demonstrated that hypoxia could revert the effects of RT in the OSCC context. However, RT reduces the levels HIF-1α, miR-210 and LDH in vivo and in vitro. The consequences of RT in blood should be carefully investigated.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>30406875</pmid><doi>10.1007/s12253-018-0517-2</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3162-3206</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Blood levels Cancer Research Cell Hypoxia - radiation effects Cell migration Cell proliferation Female Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - blood Hypoxia-Inducible Factor 1, alpha Subunit - radiation effects Immunology L-Lactate Dehydrogenase - blood L-Lactate Dehydrogenase - radiation effects Male MicroRNAs - blood MicroRNAs - radiation effects Middle Aged Migration Oncology Oral cancer Oral squamous cell carcinoma Original Article Pathology Phenotypes Proteomics Radiation Radiation therapy Radiation Tolerance Radiotherapy - adverse effects Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - radiotherapy Young Adult |
| title | Radiation Therapy Reduced Blood Levels of LDH, HIF-1α, and miR-210 in OSCC |
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