Identification of significant protein markers by mass spectrometry after co‐treatment of cells with different drugs: An in vitro survey platform

Rationale Understanding drug–drug interactions and predicting the side effects induced by polypharmacy are difficult because there are few suitable platforms that can predict drug–drug interactions and possible side effects. Hence, developing a platform to identify significant protein markers of dru...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2020-04, Vol.34 (S1), p.e8582-n/a
Hauptverfasser:	Wu, Ying‐Jung, Huang, Ching‐Hui, Hsieh, Tusty‐Jiuan, Tseng, Wei‐Lung, Lu, Chi‐Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - adverse effects Anticonvulsants - pharmacology Biomarkers - analysis Biomarkers - metabolism Cells, Cultured Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - metabolism Chromatography, High Pressure Liquid - methods Cimetidine Drug Interactions Drugs Ethosuximide - adverse effects Ethosuximide - pharmacology Humans Liver Liver - drug effects Liver - metabolism Markers Mass spectrometry Metformin Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mitochondrial Proteins - analysis Mitochondrial Proteins - metabolism Proteins Scientific imaging Side effects Spectroscopy Tandem Mass Spectrometry - methods Workflow
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