Conjugate Addition Routes to 2‐Alkyl‐2,3‐dihydroquinolin‐4(1H)‐ones and 2‐Alkyl‐4‐hydroxy‐1,2‐dihydroquinoline‐3‐carboxylates

Under CuBr·SMe2/PPh3 catalysis (5/10 mol‐%) RMgCl (R = Me, Et, nPr, CH=CH2, nBu, iBu, nC5H11, cC6H11, Bn, CH2Bn, nC11H23) readily (–78 °C) undergo 1,4‐addition to Cbz or Boc protected quinolin‐4(1H)‐ones to provide 2‐alkyl‐2,3‐dihydroquinolin‐4(1H)‐ones (14 examples, 54–99 % yield). Asymmetric versi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of inorganic chemistry 2020-03, Vol.2020 (11-12), p.1011-1017
Hauptverfasser:	Kingsbury, Alex, Brough, Steve, McCarthy, Antonio Pedrina, Lewis, William, Woodward, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanes Allyl compounds Asymmetric catalysis Carboxylates Chemical reactions Copper Crystallography Halogens Inorganic chemistry Michael addition Phosphane ligands Selectivity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!