Is antibiotic lock therapy effective for the implantable long-term catheter-related bloodstream infections in children?
Catheter-related bloodstream infections (CRBSIs) are an important problem in pediatric patients with central venous catheters. This study aimed to determine the incidence of CRBSIs, responsible pathogens and outcomes of antibiotic lock treatment (ALT) in pediatric patients. Between January 2010 and...
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| Veröffentlicht in: | Turkish journal of pediatrics 2019-11, Vol.61 (6), p.895-904 |
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| container_title | Turkish journal of pediatrics |
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| creator | Kara, Tuğçe Tural Özdemir, Halil Erat, Tuğba Yahşi, Aysun Aysev, Ahmet Derya Taçyıldız, Nurdan Ünal, Emel İleri, Talia İnce, Elif Haskoloğlu, Şule Çiftçi, Ergin İnce, Erdal |
| description | Catheter-related bloodstream infections (CRBSIs) are an important problem in pediatric patients with central venous catheters. This study aimed to determine the incidence of CRBSIs, responsible pathogens and outcomes of antibiotic lock treatment (ALT) in pediatric patients. Between January 2010 and November 2015 all hospitalized pediatric hematology, oncology and immunology patients diagnosed with CRBSIs were retrospectively analyzed.Seventy-eight CRBSI episodes were detected in 60 pediatric patients. The incidence of CRBSIs was 4.20/1000 catheter days. The most frequently detected pathogen was methicillin-resistant coagulase-negative Staphylococcus. Pseudomonas aeruginosa, Klebsiella spp., and Escherichia coli were other commonly isolated microorganisms. ALT was administered in 42 patients. The success rate of ALT was 81% (34/42). Catheter was removed without ALT in 36 episodes. Common reasons for catheter removal were sepsis and causative microorganisms which had high probability of biofilm formation.CRBSIs are an important cause of morbidity and mortality in pediatric patients. ALT is safe and effective. It is possible to obtain satisfactory results when ALT is used with intravenous systemic antibiotics for CRBSIs, though in some cases catheter removal is necessary. ALT helps to prevent unnecessary catheter removal in pediatric patients. |
| doi_str_mv | 10.24953/turkjped.2019.06.011 |
| format | Article |
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This study aimed to determine the incidence of CRBSIs, responsible pathogens and outcomes of antibiotic lock treatment (ALT) in pediatric patients. Between January 2010 and November 2015 all hospitalized pediatric hematology, oncology and immunology patients diagnosed with CRBSIs were retrospectively analyzed.Seventy-eight CRBSI episodes were detected in 60 pediatric patients. The incidence of CRBSIs was 4.20/1000 catheter days. The most frequently detected pathogen was methicillin-resistant coagulase-negative Staphylococcus. Pseudomonas aeruginosa, Klebsiella spp., and Escherichia coli were other commonly isolated microorganisms. ALT was administered in 42 patients. The success rate of ALT was 81% (34/42). Catheter was removed without ALT in 36 episodes. Common reasons for catheter removal were sepsis and causative microorganisms which had high probability of biofilm formation.CRBSIs are an important cause of morbidity and mortality in pediatric patients. ALT is safe and effective. It is possible to obtain satisfactory results when ALT is used with intravenous systemic antibiotics for CRBSIs, though in some cases catheter removal is necessary. ALT helps to prevent unnecessary catheter removal in pediatric patients.</description><identifier>ISSN: 0041-4301</identifier><identifier>DOI: 10.24953/turkjped.2019.06.011</identifier><language>eng</language><publisher>Ankara: Hacettepe University Faculty of Medicine</publisher><subject>Antibiotics ; Biofilms ; Catheters ; Hematology ; Immunology ; Leukemia ; Localization ; Microorganisms ; Mortality ; Neutrophils ; Nosocomial infections ; Oncology ; Pathogens ; Pediatrics ; Staphylococcus infections</subject><ispartof>Turkish journal of pediatrics, 2019-11, Vol.61 (6), p.895-904</ispartof><rights>Copyright Hacettepe University Faculty of Medicine Nov/Dec 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kara, Tuğçe Tural</creatorcontrib><creatorcontrib>Özdemir, Halil</creatorcontrib><creatorcontrib>Erat, Tuğba</creatorcontrib><creatorcontrib>Yahşi, Aysun</creatorcontrib><creatorcontrib>Aysev, Ahmet Derya</creatorcontrib><creatorcontrib>Taçyıldız, Nurdan</creatorcontrib><creatorcontrib>Ünal, Emel</creatorcontrib><creatorcontrib>İleri, Talia</creatorcontrib><creatorcontrib>İnce, Elif</creatorcontrib><creatorcontrib>Haskoloğlu, Şule</creatorcontrib><creatorcontrib>Çiftçi, Ergin</creatorcontrib><creatorcontrib>İnce, Erdal</creatorcontrib><title>Is antibiotic lock therapy effective for the implantable long-term catheter-related bloodstream infections in children?</title><title>Turkish journal of pediatrics</title><description>Catheter-related bloodstream infections (CRBSIs) are an important problem in pediatric patients with central venous catheters. This study aimed to determine the incidence of CRBSIs, responsible pathogens and outcomes of antibiotic lock treatment (ALT) in pediatric patients. Between January 2010 and November 2015 all hospitalized pediatric hematology, oncology and immunology patients diagnosed with CRBSIs were retrospectively analyzed.Seventy-eight CRBSI episodes were detected in 60 pediatric patients. The incidence of CRBSIs was 4.20/1000 catheter days. The most frequently detected pathogen was methicillin-resistant coagulase-negative Staphylococcus. Pseudomonas aeruginosa, Klebsiella spp., and Escherichia coli were other commonly isolated microorganisms. ALT was administered in 42 patients. The success rate of ALT was 81% (34/42). Catheter was removed without ALT in 36 episodes. Common reasons for catheter removal were sepsis and causative microorganisms which had high probability of biofilm formation.CRBSIs are an important cause of morbidity and mortality in pediatric patients. ALT is safe and effective. It is possible to obtain satisfactory results when ALT is used with intravenous systemic antibiotics for CRBSIs, though in some cases catheter removal is necessary. ALT helps to prevent unnecessary catheter removal in pediatric patients.</description><subject>Antibiotics</subject><subject>Biofilms</subject><subject>Catheters</subject><subject>Hematology</subject><subject>Immunology</subject><subject>Leukemia</subject><subject>Localization</subject><subject>Microorganisms</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>Nosocomial infections</subject><subject>Oncology</subject><subject>Pathogens</subject><subject>Pediatrics</subject><subject>Staphylococcus infections</subject><issn>0041-4301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNotjU1PxCAYhDlo4rr6E0xIPLdCgRZOxmz82GQTL3reUHhx6bKlAqvx31s_TvNkZjKD0BUldcOVYDflmPbDBLZuCFU1aWtC6QlaEMJpxRmhZ-g854GQpiOqW6DPdcZ6LL73sXiDQzR7XHaQ9PSFwTkwxX8AdjH9uNgfpjC3dR9gro5vVYF0wEbP2UxVgqALWNyHGG0uCfQB-_F3JI55Rmx2PtgE4-0FOnU6ZLj81yV6fbh_WT1Vm-fH9epuU01UslI5QbjuO9sLY5UT0jbUKilAcOh004EF1RreagocWpDGGdVRKazsmGn7RrIluv7bnVJ8P0Iu2yEe0zhfbhsmORWtEpR9A9KBYd8</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Kara, Tuğçe Tural</creator><creator>Özdemir, Halil</creator><creator>Erat, Tuğba</creator><creator>Yahşi, Aysun</creator><creator>Aysev, Ahmet Derya</creator><creator>Taçyıldız, Nurdan</creator><creator>Ünal, Emel</creator><creator>İleri, Talia</creator><creator>İnce, Elif</creator><creator>Haskoloğlu, Şule</creator><creator>Çiftçi, Ergin</creator><creator>İnce, Erdal</creator><general>Hacettepe University Faculty of Medicine</general><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20191101</creationdate><title>Is antibiotic lock therapy effective for the implantable long-term catheter-related bloodstream infections in children?</title><author>Kara, Tuğçe Tural ; 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This study aimed to determine the incidence of CRBSIs, responsible pathogens and outcomes of antibiotic lock treatment (ALT) in pediatric patients. Between January 2010 and November 2015 all hospitalized pediatric hematology, oncology and immunology patients diagnosed with CRBSIs were retrospectively analyzed.Seventy-eight CRBSI episodes were detected in 60 pediatric patients. The incidence of CRBSIs was 4.20/1000 catheter days. The most frequently detected pathogen was methicillin-resistant coagulase-negative Staphylococcus. Pseudomonas aeruginosa, Klebsiella spp., and Escherichia coli were other commonly isolated microorganisms. ALT was administered in 42 patients. The success rate of ALT was 81% (34/42). Catheter was removed without ALT in 36 episodes. Common reasons for catheter removal were sepsis and causative microorganisms which had high probability of biofilm formation.CRBSIs are an important cause of morbidity and mortality in pediatric patients. ALT is safe and effective. It is possible to obtain satisfactory results when ALT is used with intravenous systemic antibiotics for CRBSIs, though in some cases catheter removal is necessary. ALT helps to prevent unnecessary catheter removal in pediatric patients.</abstract><cop>Ankara</cop><pub>Hacettepe University Faculty of Medicine</pub><doi>10.24953/turkjped.2019.06.011</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Antibiotics Biofilms Catheters Hematology Immunology Leukemia Localization Microorganisms Mortality Neutrophils Nosocomial infections Oncology Pathogens Pediatrics Staphylococcus infections |
| title | Is antibiotic lock therapy effective for the implantable long-term catheter-related bloodstream infections in children? |
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